Summary statistics The study population included 3,917 participants undergoing 1st -line treatment for ER + MBC with CDK4/6i plus ET (n = 2,170) or ET alone...
Tag - CDK46
As a result of the widespread use of CDK4/6 inhibitors and increasing awareness among healthcare providers, the number of AEs reported has escalated over the...
Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Zucman-Rossi J, Finn RS. Hepatocellular carcinoma. Nat Rev Dis...
Cell cycle events are coordinated by cyclin-dependent kinases (CDKs) to ensure robust cell division. CDK4/6 and CDK2 regulate the growth 1 (G1) to synthesis...
The genotoxicity test results for PD0332991 were negative in the Ames test, negative in the in vitro chromosome aberration test using human cells, positive in...
Xu H, Yu S, Liu Q, Yuan X, Mani S, Pestell RG, et al. Recent advances of highly selective CDK4/6 inhibitors in breast cancer. J Hematol Oncol. 2017;10(1):97. ...