Pedretti RFE, Hansen D, Ambrosetti M, Back M, Berger T, Ferreira MC, et al. How to optimize the adherence to a guideline-directed medical therapy in the secondary prevention of cardiovascular diseases: a clinical consensus statement from the European Association of Preventive Cardiology. Eur J Prev Cardiol. 2023;30(2):149–66. https://doi.org/10.1093/eurjpc/zwac204.
Farhat G, Drummond S, Al-Dujaili EAS. Polyphenols and their role in obesity management: a systematic review of randomized clinical trials. Phytother Res. 2017;31(7):1005–18. https://doi.org/10.1002/ptr.5830.
Catalkaya G, Venema K, Lucini L, Rocchetti G, Delmas D, Daglia M, et al. Interaction of dietary polyphenols and gut microbiota: microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health. Food Front. 2020;1(2):109–33. https://doi.org/10.1002/fft2.25.
Chen L, Cao H, Xiao J. 2 – polyphenols: absorption, bioavailability, and metabolomics. In: Galanakis CM, editor. Polyphenols: properties, recovery, and applications. Sawston: Woodhead Publishing; 2018. p. 45–67.
Andres-Lacueva C, Macarulla MT, Rotches-Ribalta M, Boto-Ordóñez M, Urpi-Sarda M, Rodríguez VM, et al. Distribution of resveratrol metabolites in liver, adipose tissue, and skeletal muscle in rats fed different doses of this polyphenol. J Agric Food Chem. 2012;60(19):4833–40. https://doi.org/10.1021/jf3001108.
Janle EM, Lila MA, Grannan M, Wood L, Higgins A, Yousef GG, et al. Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration. J Med Food. 2010;13(4):926–33. https://doi.org/10.1089/jmf.2009.0157.
Les F, Carpéné C, Arbonés-Mainar JM, Decaunes P, Valero MS, López V. Pomegranate juice and its main polyphenols exhibit direct effects on amine oxidases from human adipose tissue and inhibit lipid metabolism in adipocytes. J Funct Foods. 2017;33:323–31.
Assini JM, Mulvihill EE, Burke AC, Sutherland BG, Telford DE, Chhoker SS, et al. Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21. Endocrinology. 2015;156(6):2087–102. https://doi.org/10.1210/en.2014-2003.
Chtourou Y, Fetoui H, Jemai R, ben Slima A, Makni M, Gdoura R. Naringenin reduces cholesterol-induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway. Eur J Pharmacol. 2015;746:96–105.
Mayneris-Perxachs J, Alcaide-Hidalgo JM, de la Hera E, del Bas JM, Arola L, Caimari A. Supplementation with biscuits enriched with hesperidin and naringenin is associated with an improvement of the Metabolic Syndrome induced by a cafeteria diet in rats. J Funct Foods. 2019;61:103504.
Demonty I, Lin Y, Zebregs YEMP, Vermeer MA, van der Knaap HCM, Jäkel M, et al. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. J Nutr. 2010;140(9):1615–20. https://doi.org/10.3945/jn.110.124735.
Bolca S, van de Wiele T, Possemiers S. Gut metabotypes govern health effects of dietary polyphenols. Curr Opin Biotechnol. 2013;24(2):220–5.
Mena P, Ludwig IA, Tomatis VB, Acharjee A, Calani L, Rosi A, et al. Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes. Eur J Nutr. 2019;58(4):1529–43. https://doi.org/10.1007/s00394-018-1683-4.
Manach C, Morand C, Gil-Izquierdo A, Bouteloup-Demange C, Rémésy C. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr. 2003;57(2):235–42.
Corrêa TAF, Rogero MM, Hassimotto NMA, Lajolo FM. The two-way polyphenols-microbiota interactions and their effects on obesity and related metabolic diseases. Front Nutr. 2019;6:188.
Ma G, Chen Y. Polyphenol supplementation benefits human health via gut microbiota: a systematic review via meta-analysis. J Funct Foods. 2020;66:103829.
Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia. 2007;50(11):2374–83. https://doi.org/10.1007/s00125-007-0791-0.
Liao ZL, Zeng BH, Wang W, Li GH, Wu F, Wang L, et al. Impact of the consumption of tea polyphenols on early atherosclerotic lesion formation and intestinal Bifidobacteria in high-fat-fed ApoE−/− mice. Front Nutr. 2016;3:42.
Cases J, Romain C, Dallas C, Gerbi A, Rouanet JM. A 12-week randomized double-blind parallel pilot trial of Sinetrol XPur on body weight, abdominal fat, waist circumference, and muscle metabolism in overweight men. Int J Food Sci Nutr. 2015;66(4):471–7. https://doi.org/10.3109/09637486.2015.1042847.
Dallas C, Gerbi A, Elbez Y, Caillard P, Zamaria N, Cloarec M. Clinical study to assess the efficacy and safety of a citrus polyphenolic extract of red orange, grapefruit, and orange (Sinetrol-XPur) on weight management and metabolic parameters in healthy overweight individuals. Phytother Res. 2014;28(2):212–8. https://doi.org/10.1002/ptr.4981.
Muralidharan J, Romain C, Bresciani L, Mena P, Angelino D, Del RD, et al. Nutrikinetics and urinary excretion of phenolic compounds after a 16-week supplementation with a flavanone-rich ingredient. Food Funct. 2023;14(23):10506–19.
Brindani N, Mena P, Calani L, Benzie I, Choi SW, Brighenti F, et al. Synthetic and analytical strategies for the quantification of phenyl-γ-valerolactone conjugated metabolites in human urine. Mol Nutr Food Res. 2017;61(9):1700077. https://doi.org/10.1002/mnfr.201700077.
Lluch J, Servant F, Païssé S, Valle C, Valière S, Kuchly C, et al. The characterization of novel tissue microbiota using an optimized 16s metagenomic sequencing pipeline. PLoS One. 2015;10(11):e0142334. https://doi.org/10.1371/journal.pone.0142334.
Escudié F, Auer L, Bernard M, Mariadassou M, Cauquil L, Vidal K, et al. FROGS: find, rapidly, OTUs with galaxy solution. Bioinformatics. 2018;34(8):1287–94. https://doi.org/10.1093/bioinformatics/btx791.
Gruzdeva O, Borodkina D, Uchasova E, Dyleva Y, Barbarash O. Leptin resistance: underlying mechanisms and diagnosis. Diabetes Metab Syndr Obes. 2019;12:191.
Owecki M, Nikisch E, Miczke A, Pupek-Musialik D, Sowiski J. Leptin, soluble leptin receptors, free leptin index, and their relationship with insulin resistance and BMI: high normal BMI is the threshold for serum leptin increase in humans. Horm Metab Res. 2010;42(8):585–9. https://doi.org/10.1055/s-0030-1253422.
Wang X, Li D, Liu F, Cui Y, Li X. Dietary citrus and/or its extracts intake contributed to weight control: evidence from a systematic review and meta-analysis of 13 randomized clinical trials. Phytother Res. 2020;34(8):2006–22. https://doi.org/10.1002/ptr.6673.
Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, et al. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia. 2011;82(3):309–16.
Ren B, Qin W, Wu F, Wang S, Pan C, Wang L, et al. Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats. Eur J Pharmacol. 2016;773:13–23.
Jung UJ, Lee MK, Park YB, Kang MA, Choi MS. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol. 2006;38(7):1134–45.
Wang F, Zhao C, Yang M, Zhang L, Wei R, Meng K, et al. Four citrus flavanones exert atherosclerosis alleviation effects in ApoE–/– mice via different metabolic and signaling pathways. J Agric Food Chem. 2021;69(17):5226–37. https://doi.org/10.1021/acs.jafc.1c01463.
Sost MM, Ahles S, Verhoeven J, Verbruggen S, Stevens Y, Venema K. A citrus fruit extract high in polyphenols beneficially modulates the gut microbiota of healthy human volunteers in a validated in vitro model of the colon. Nutrients. 2021;13(11):3915.
Lozano CP, Wilkens LR, Shvetsov YB, Maskarinec G, Park SY, Shepherd JA, et al. Associations of the dietary inflammatory index with total adiposity and ectopic fat through the gut microbiota, LPS, and C-reactive protein in the multiethnic cohort-adiposity phenotype study. Am J Clin Nutr. 2022;115(5):1344–56. https://doi.org/10.1093/ajcn/nqab398.
Wei J, Zhao Y, Zhou C, Zhao Q, Zhong H, Zhu X, et al. Dietary polysaccharide from Enteromorpha clathrata attenuates obesity and increases the intestinal abundance of butyrate-producing bacterium, Eubacterium xylanophilum, in mice fed a high-fat diet. Polymers (Basel). 2021;13(19):3286.
Vaughan RA, Conn CA, Mermier CM. Effects of commercially available dietary supplements on resting energy expenditure: a brief report. ISRN Nutr. 2014;2014:650264. https://doi.org/10.1155/2014/650264.
Bressa C, Bailén-Andrino M, Pérez-Santiago J, González-Soltero R, Pérez M, Montalvo-Lominchar MG, et al. Differences in gut microbiota profile between women with active lifestyle and sedentary women. PLoS One. 2017;12(2):e0171352. https://doi.org/10.1371/journal.pone.0171352.
Canfora EE, Van Der Beek CM, Jocken JWE, Goossens GH, Holst JJ, Olde Damink SWM, et al. Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial. Sci Rep. 2017;7(1):1–12.
Cladis DP, Simpson AMR, Cooper KJ, Nakatsu CH, Ferruzzi MG, Weaver CM. Blueberry polyphenols alter gut microbiota & phenolic metabolism in rats. Food Funct. 2021;12(6):2442–56.
Hankir MK, Seyfried F. Partial leptin reduction: an emerging weight loss paradigm. Trends Endocrinol Metab. 2020;31(6):395–7.
Park SJ, Sharma A, Bae MH, Sung HC, Kim NK, Sung E, et al. Efficacy and safety of Sinetrol-XPur on weight and body fat reduction in overweight or obese adults: a 12-week, randomized, double-blind, parallel, placebo-controlled trial. J Med Food. 2020;23(3):335–42. https://doi.org/10.1089/jmf.2019.4649.
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