Scientific Papers

Computational approaches to investigate the relationship between periodontitis and cardiovascular diseases for precision medicine | Human Genomics


  • Mehrotra N, Singh S. Periodontitis. In StatPearls. 2023. https://www.ncbi.nlm.nih.gov/pubmed/31082170

  • Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim). 2017;11(2):72–80.

    PubMed 

    Google Scholar
     

  • Fenesy KE. Periodontal disease: an overview for physicians. Mt Sinai J Med. 1998;65(5–6):362–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Valm AM. The structure of dental plaque microbial communities in the transition from health to dental caries and periodontal disease. J Mol Biol. 2019;431(16):2957–69. https://doi.org/10.1016/j.jmb.2019.05.016

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Medeiros RA, Silva YMD, Miranda YMS, Gomes DS, Carvalho TRB, Tanaka EB, Oliveira P, Nogueira JSE, Menezes SAF, Menezes TOA, Laurentino RV, Fonseca RRS, Machado LFA. Digital form for assessing dentistry undergraduates regarding periodontal disease associated with cardiovascular diseases. Med (Kaunas). 2023;59(3). https://doi.org/10.3390/medicina59030509

  • Gaziano T, Reddy KS, Paccaud F, Horton S, Chaturvedi V. Cardiovascular disease. In D. T. Jamison, J. G. Breman, A. R. Measham, G. Alleyne, M. Claeson, D. B. Evans, P. Jha, A. Mills, & P. Musgrove, editors, Disease Control Priorities in Developing Countries (2nd ed.). 2006. https://www.ncbi.nlm.nih.gov/pubmed/21250342

  • Sethi Y, Patel N, Kaka N, Kaiwan O, Kar J, Moinuddin A, Goel A, Chopra H, Cavalu S. Precision medicine and the future of cardiovascular diseases: a clinically oriented comprehensive review. J Clin Med. 2023;12(5). https://doi.org/10.3390/jcm12051799

  • Gaidai O, Cao Y, Loginov S. Global cardiovascular diseases death rate prediction. Curr Probl Cardiol. 2023;48(5):101622. https://doi.org/10.1016/j.cpcardiol.2023.101622

    Article 
    PubMed 

    Google Scholar
     

  • Henein MY, Vancheri S, Longo G, Vancheri F. The role of inflammation in cardiovascular disease. Int J Mol Sci. 2022;23(21). https://doi.org/10.3390/ijms232112906

  • Crowson CS, Liao KP, Davis JM 3rd, Solomon DH, Matteson EL, Knutson KL, Hlatky MA, Gabriel SE. Rheumatoid arthritis and cardiovascular disease. Am Heart J. 2013;166(4):622–e628621. https://doi.org/10.1016/j.ahj.2013.07.010

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Leon BM, Maddox TM. Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015;6(13):1246–58. https://doi.org/10.4239/wjd.v6.i13.1246

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tian Z, Mclaughlin J, Verma A, Chinoy H, Heald AH. The relationship between rheumatoid arthritis and diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Endocrinol Metabolism. 2021;10(2):125–31. https://doi.org/10.1097/XCE.0000000000000244

    Article 
    CAS 

    Google Scholar
     

  • Samborska-Mazur J, Sikorska D, Wyganowska-Świątkowska M. The relationship between periodontal status and rheumatoid arthritis – systematic review. Reumatologia. 2020;58(4):236–42. https://doi.org/10.5114/reum.2020.98436

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zardawi F, Gul S, Abdulkareem A, Sha A, Yates J. Association between periodontal disease and atherosclerotic cardiovascular diseases: revisited. Front Cardiovasc Med. 2021;7:625579. https://doi.org/10.3389/fcvm.2020.625579

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Leng Y, Hu Q, Ling Q, Yao X, Liu M, Chen J, Yan Z, Dai Q. Periodontal disease is associated with the risk of cardiovascular disease independent of sex: a meta-analysis. Front Cardiovasc Med. 2023;10:1114927. https://doi.org/10.3389/fcvm.2023.1114927

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Febbraio M, Roy CB, Levin L. Is there a causal link between periodontitis and cardiovascular disease? A concise review of recent findings. Int Dent J. 2022;72(1):37–51. https://doi.org/10.1016/j.identj.2021.07.006

    Article 
    PubMed 

    Google Scholar
     

  • Kikuchi T, Hayashi JI, Mitani A. Next-generation examination, diagnosis, and personalized medicine in periodontal disease. J Pers Med. 2022;12(10). https://doi.org/10.3390/jpm12101743

  • Reed SC, Dhir N, Widmer RJ. Optimal cardiovascular medical therapy: current guidelines and new developments. Proc (Bayl Univ Med Cent). 2022;35(5):636–42. https://doi.org/10.1080/08998280.2022.2083903

    Article 
    PubMed 

    Google Scholar
     

  • Madi M, Shetty SR, Babu SG, Achalli S. Amlodipine-induced gingival hyperplasia – a case report and review. West Indian Med J. 2015;64(3):279–82. https://doi.org/10.7727/wimj.2014.089

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Goodarzi MO, Rotter JI. Genetics insights in the relationship between type 2 diabetes and coronary heart disease. Circ Res. 2020;126(11):1526–48. https://doi.org/10.1161/circresaha.119.316065

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Delpierre C, Lefevre T. Precision and personalized medicine: what their current definition says and silences about the model of health they promote. Implication for the development of personalized health. Front Sociol. 2023;8:1112159. https://doi.org/10.3389/fsoc.2023.1112159

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • McGinnis JM, Williams-Russo P, Knickman JR. The case for more active policy attention to health promotion. Health Aff (Millwood). 2002;21(2):78–93. https://doi.org/10.1377/hlthaff.21.2.78

    Article 
    PubMed 

    Google Scholar
     

  • van der Schee M, Pinheiro H, Gaude E. Breath biopsy for early detection and precision medicine in cancer. Ecancermedicalscience. 2018;12:ed84. https://doi.org/10.3332/ecancer.2018.ed84

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ahmed Z. Multi-omics strategies for personalized and predictive medicine: past, current, and future translational opportunities. Emerg Top Life Sci. 2022;6(2):215–25. https://doi.org/10.1042/ETLS20210244

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ahmed Z, Renart EG, Zeeshan S. Genomics pipelines to investigate susceptibility in whole genome and exome sequenced data for variant discovery, annotation, prediction and genotyping. PeerJ. 2021;9:e11724. https://doi.org/10.7717/peerj.11724

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Slikker W Jr. Biomarkers and their impact on precision medicine. Exp Biol Med (Maywood). 2018;243(3):211–2. https://doi.org/10.1177/1535370217733426

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bartold PM, Ivanovski S. P4 medicine as a model for precision periodontal care. Clin Oral Investig. 2022;26(9):5517–33. https://doi.org/10.1007/s00784-022-04469-y

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang RS, Maron BA, Loscalzo J. Multiomics network medicine approaches to precision medicine and therapeutics in cardiovascular diseases. Arterioscler Thromb Vasc Biol. 2023;43(4):493–503. https://doi.org/10.1161/ATVBAHA.122.318731

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schaefer AS, Bochenek G, Jochens A, Ellinghaus D, Dommisch H, Guzeldemir-Akcakanat E, Graetz C, Harks I, Jockel-Schneider Y, Weinspach K, Meyle J, Eickholz P, Linden GJ, Cine N, Nohutcu R, Weiss E, Houri-Haddad Y, Iraqi F, Folwaczny M, Schreiber S. Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. Circ Cardiovasc Genet. 2015;8(1):159–67. https://doi.org/10.1161/CIRCGENETICS.114.000554

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Munz M, Richter GM, Loos BG, Jepsen S, Divaris K, Offenbacher S, Teumer A, Holtfreter B, Kocher T, Bruckmann C, Jockel-Schneider Y, Graetz C, Munoz L, Bhandari A, Tennstedt S, Staufenbiel I, van der Velde N, Uitterlinden AG, de Groot L, Schaefer AS. Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus. Sci Rep. 2018;8(1):13678. https://doi.org/10.1038/s41598-018-31980-8

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mahendra J, Rao AN, Mahendra L, Sayed ME, Mugri MH, Balaji TM, Varadarajan S, Jagannathan R, Srinivasan S, Baeshen HA, Mathew R, Patil S. The expression of allele changes in NLRP3 (rs35829419) and IL-1β (+ 3954) gene polymorphisms in periodontitis and coronary artery disease. Mater (Basel Switzerland). 2021;14(17):5103. https://doi.org/10.3390/ma14175103

    Article 
    CAS 

    Google Scholar
     

  • Dong W, Gong Y, Yang B, et al. Bioinformatics analysis and reveal potential crosstalk genetic and immune relationships between atherosclerosis and periodontitis. Sci Rep. 2023;13:10381. https://doi.org/10.1038/s41598-023-37027-x

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou M, Dong J, Zha L, Liao Y. Causal association between periodontal diseases and cardiovascular diseases. Genes (Basel). 2021;13(1). https://doi.org/10.3390/genes13010013

  • Bell S, Gibson JT, Harshfield EL, Markus HS. Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomization study. Atherosclerosis. 2020;313:111–7. https://doi.org/10.1016/j.atherosclerosis.2020.09.029

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Czesnikiewicz-Guzik M, Osmenda G, Siedlinski M, Nosalski R, Pelka P, Nowakowski D, Wilk G, Mikolajczyk TP, Schramm-Luc A, Furtak A, Matusik P, Koziol J, Drozdz M, Munoz-Aguilera E, Tomaszewski M, Evangelou E, Caulfield M, Grodzicki T, D’Aiuto F, Guzik TJ. Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy. Eur Heart J. 2019;40(42):3459–70. https://doi.org/10.1093/eurheartj/ehz646

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ma C, Wu M, Gao J, Liu C, Xie Y, Lv Q, Zhang X. Periodontitis and stroke: a Mendelian randomization study. Brain Behav. 2023;13(2):e2888. https://doi.org/10.1002/brb3.2888

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zeng Y, Cao S, Chen M. Integrated analysis and exploration of potential shared gene signatures between carotid atherosclerosis and periodontitis. BMC Med Genomics. 2022;15(1):227. https://doi.org/10.1186/s12920-022-01373-y

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Leira Y, Mascarenhas P, Blanco J, Sobrino T, Mendes JJ, Machado V, Botelho J. Network protein interaction in the link between stroke and periodontitis interplay: a pilot bioinformatic analysis. Genes (Basel). 2021;12(5). https://doi.org/10.3390/genes12050787

  • Ferlazzo N, Curro M, Isola G, Maggio S, Bertuccio MP, Trovato-Salinaro A, Matarese G, Alibrandi A, Caccamo D, Ientile R. Changes in the biomarkers of oxidative/nitrosative stress and endothelial dysfunction are associated with cardiovascular risk in periodontitis patients. Curr Issues Mol Biol. 2021;43(2):704–15. https://doi.org/10.3390/cimb43020051

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lundmark A, Davanian H, Bage T, Johannsen G, Koro C, Lundeberg J, Yucel-Lindberg T. Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases. Sci Rep. 2015;5:18475. https://doi.org/10.1038/srep18475

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Carter CJ, France J, Crean S, Singhrao SK. The Porphyromonas gingivalis/Host interactome shows enrichment in GWASdb genes related to Alzheimer’s disease, diabetes and cardiovascular diseases. Front Aging Neurosci. 2017;9:408. https://doi.org/10.3389/fnagi.2017.00408

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Patel KK, Venkatesan C, Abdelhalim H, Zeeshan S, Arima Y, Linna-Kuosmanen S, Ahmed Z. Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility. Hum Genomics. 2023;17(1):47. https://doi.org/10.1186/s40246-023-00498-0

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ahmed Z, Zeeshan S, Liang BT. RNA-seq driven expression and enrichment analysis to investigate CVD genes with associated phenotypes among high-risk heart failure patients. Hum Genomics. 2021;15(1):67. https://doi.org/10.1186/s40246-021-00367-8

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mhatre I, Abdelhalim H, Degroat W, Ashok S, Liang BT, Ahmed Z. Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases. Sci Rep. 2023;13(1):16769. https://doi.org/10.1038/s41598-023-44127-1

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9(6):7204–18. https://doi.org/10.18632/oncotarget.23208

    Article 
    PubMed 

    Google Scholar
     

  • Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;6(10):a016295. https://doi.org/10.1101/cshperspect.a016295

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol. 2003;74(3):391–401. https://doi.org/10.1902/jop.2003.74.3.391

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gui Y, Zheng H, Cao RY. Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms. Front Cardiovasc Med. 2022;9:845942. https://doi.org/10.3389/fcvm.2022.845942

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kanda T, Takahashi T. Interleukin-6 and cardiovascular diseases. Jpn Heart J. 2004;45(2):183–93. https://doi.org/10.1536/jhj.45.183

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Feng Y, Ye D, Wang Z, Pan H, Lu X, Wang M, Xu Y, Yu J, Zhang J, Zhao M, Xu S, Pan W, Yin Z, Ye J, Wan J. The role of interleukin-6 family members in cardiovascular diseases. Front Cardiovasc Med. 2022;9:818890. https://doi.org/10.3389/fcvm.2022.818890

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cardoso EM, Reis C, Manzanares-Cespedes MC. Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases. Postgrad Med. 2018;130(1):98–104. https://doi.org/10.1080/00325481.2018.1396876

    Article 
    PubMed 

    Google Scholar
     

  • Lagrand WK, Visser CA, Hermens WT, Niessen HW, Verheugt FW, Wolbink GJ, Hack CE. C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon? Circulation. 1999;100(1):96–102. https://doi.org/10.1161/01.cir.100.1.96

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Speidl WS, Kastl SP, Huber K, Wojta J. Complement in atherosclerosis: friend or foe? J Thromb Haemost. 2011;9(3):428–40. https://doi.org/10.1111/j.1538-7836.2010.04172.x

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Maekawa Y, Nagai T, Anzai A. Pentraxins: CRP and PTX3 and cardiovascular disease. Inflamm Allergy Drug Targets. 2011;10(4):229–35. https://doi.org/10.2174/187152811796117744

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Emerging R, Factors C, Kaptoge S, Di Angelantonio E, Lowe G, Pepys MB, Thompson SG, Collins R, Danesh J. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375(9709):132–40. https://doi.org/10.1016/S0140-6736(09)61717-7

    Article 
    CAS 

    Google Scholar
     

  • Machado V, Botelho J, Escalda C, Hussain SB, Luthra S, Mascarenhas P, Orlandi M, Mendes JJ, D’Aiuto F. Serum C-reactive protein and periodontitis: a systematic review and meta-analysis. Front Immunol. 2021;12:706432. https://doi.org/10.3389/fimmu.2021.706432

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang LY, Tan CS, Lai MKP, Hilal S. Factors associated with RANTES, EMMPIRIN, MMP2 and MMP9, and the association of these biomarkers with cardiovascular disease in a multi-ethnic population. J Clin Med. 2022;11(24). https://doi.org/10.3390/jcm11247281

  • Peeters SA, Engelen L, Buijs J, Jorsal A, Parving HH, Tarnow L, Rossing P, Schalkwijk CG, Stehouwer CDA. Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study. Cardiovasc Diabetol. 2017;16(1):55. https://doi.org/10.1186/s12933-017-0539-1

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Makela M, Salo T, Uitto VJ, Larjava H. Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: cellular origin and relationship to periodontal status. J Dent Res. 1994;73(8):1397–406. https://doi.org/10.1177/00220345940730080201

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett NW. Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev. 2014;94(1):265–301. https://doi.org/10.1152/physrev.00031.2013

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mistrova E, Kruzliak P, Chottova Dvorakova M. Role of substance P in the cardiovascular system. Neuropeptides. 2016;58:41–51. https://doi.org/10.1016/j.npep.2015.12.005

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Loos BG, Van Dyke TE. The role of inflammation and genetics in periodontal disease. Periodontol 2000. 2020;83(1):26–39. https://doi.org/10.1111/prd.12297

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dehlin HM, Levick SP. Substance P in heart failure: the good and the bad. Int J Cardiol. 2014;170(3):270–7. https://doi.org/10.1016/j.ijcard.2013.11.010

    Article 
    PubMed 

    Google Scholar
     

  • de Avila ED, de Molon RS, de Godoi Goncalves DA, Camparis CM. Relationship between levels of neuropeptide substance P in periodontal disease and chronic pain: a literature review. J Investig Clin Dent. 2014;5(2):91–7. https://doi.org/10.1111/jicd.12087

    Article 
    PubMed 

    Google Scholar
     

  • Shao D, Tian R. Glucose transporters in cardiac metabolism and hypertrophy. Compr Physiol. 2015;6(1):331–51. https://doi.org/10.1002/cphy.c150016

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Trum M, Wagner S, Maier LS, Mustroph J. CaMKII and GLUT1 in heart failure and the role of gliflozins. Biochim Biophys Acta Mol Basis Dis. 2020;1866(6):165729. https://doi.org/10.1016/j.bbadis.2020.165729

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Obaid M, Udden SMN, Alluri P, Mandal SS. LncRNA HOTAIR regulates glucose transporter Glut1 expression and glucose uptake in macrophages during inflammation. Sci Rep. 2021;11(1):232. https://doi.org/10.1038/s41598-020-80291-4

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Q, Nie L, Zhao P, Zhou X, Ding Y, Chen Q, Wang Q. Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging. Int J Oral Sci. 2021;13(1):11. https://doi.org/10.1038/s41368-021-00116-6

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Razeghian-Jahromi I, Akhormeh K, A., Zibaeenezhad MJ. The role of ANRIL in atherosclerosis. Disease markers, 2022;2022:8859677. https://doi.org/10.1155/2022/8859677

  • Hernandez-Monjaraz B, Santiago-Osorio E, Ledesma-Martinez E, Aguiniga-Sanchez I, Sosa-Hernandez NA, Mendoza-Nunez VM. Dental pulp mesenchymal stem cells as a treatment for periodontal disease in older adults. Stem Cells Int. 2020;2020:8890873. https://doi.org/10.1155/2020/8890873

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schaefer AS, Richter GM, Dommisch H, Reinartz M, Nothnagel M, Noack B, Laine ML, Folwaczny M, Groessner-Schreiber B, Loos BG, Jepsen S, Schreiber S. CDKN2BAS is associated with periodontitis in different European populations and is activated by bacterial infection. J Med Genet. 2011;48(1):38–47. https://doi.org/10.1136/jmg.2010.078998

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xue L, Borne Y, Mattisson IY, Wigren M, Melander O, Ohro-Melander M, Bengtsson E, Fredrikson GN, Nilsson J, Engstrom G. FADD, caspase-3, and caspase-8 and incidence of coronary events. Arterioscler Thromb Vasc Biol. 2017;37(5):983–9. https://doi.org/10.1161/ATVBAHA.117.308995

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shi J, Li J, Su W, Zhao S, Li H, Lei L. Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis. Sci Rep. 2019;9(1):2902. https://doi.org/10.1038/s41598-019-39721-1

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Du Q, Liao Q, Chen C, Yang X, Xie R, Xu J. The role of transient receptor potential vanilloid 1 in common diseases of the digestive tract and the cardiovascular and respiratory system. Front Physiol. 2019;10:1064. https://doi.org/10.3389/fphys.2019.01064

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu X, Li Y, Yang Z, Zhou Z. Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway. Iran J Basic Med Sci. 2022;25(5):635–42. https://doi.org/10.22038/IJBMS.2022.62992.13924

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Takahashi N, Matsuda Y, Sato K, et al. Neuronal TRPV1 activation regulates alveolar bone resorption by suppressing osteoclastogenesis via CGRP. Sci Rep. 2016;6:29294. https://doi.org/10.1038/srep29294

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sanz, M., Marco Del Castillo, A., Jepsen, S., Gonzalez-Juanatey, J. R., D’Aiuto, F.,Bouchard, P., Chapple, I., Dietrich, T., Gotsman, I., Graziani, F., Herrera, D., Loos,B., Madianos, P., Michel, J. B., Perel, P., Pieske, B., Shapira, L., Shechter, M.,Tonetti, M., Vlachopoulos, C., … Wimmer, G. Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol. 2020;47(3):268–288. https://doi.org/10.1111/jcpe.13189

  • Ferrari R. The role of TNF in cardiovascular disease. Pharmacol Res. 1999;40(2):97–105. https://doi.org/10.1006/phrs.1998.0463

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tzavlaki K, Moustakas A. TGF-β signaling. Biomolecules. 2020;10(3):487. https://doi.org/10.3390/biom10030487

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aarabi G, Zeller T, Seedorf H, Reissmann DR, Heydecke G, Schaefer AS, Seedorf U. Genetic susceptibility contributing to periodontal and cardiovascular disease. J Dent Res. 2017;96(6):610–7. https://doi.org/10.1177/0022034517699786

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Quazi S. Artificial intelligence and machine learning in precision and genomic medicine. Med Oncol (Northwood Lond Engl). 2022;39(8):120. https://doi.org/10.1007/s12032-022-01711-1

    Article 

    Google Scholar
     

  • Ahmed Z, Mohamed K, Zeeshan S, Dong X. Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine. Database: J Biol Databases Curation. 2020;2020:baaa010. https://doi.org/10.1093/database/baaa010

    Article 

    Google Scholar
     

  • Vadapalli S, Abdelhalim H, Zeeshan S, Ahmed Z. Artificial intelligence and machine learning approaches using gene expression and variant data for personalized medicine. Brief Bioinform. 2022;23(5):bbac191. https://doi.org/10.1093/bib/bbac191

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • DeGroat W, Mendhe D, Bhusari A, Abdelhalim H, Zeeshan S, Ahmed Z. IntelliGenes: a novel machine learning pipeline for biomarker discovery and predictive analysis using multi-genomic profiles. Bioinf (Oxford England). 2023;btad755. https://doi.org/10.1093/bioinformatics/btad755. Advance online publication.

  • Ahmed Z. Deciphering expression and variants in cardiovascular disease genes among heart failure population for precision medicine. ESC Heart Fail. 2023. https://doi.org/10.1002/ehf2.14653. Advance online publication.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ahmed Z, Degroat W, Abdelhalim H, Zeeshan S, Fine D. Deciphering genomic signatures associating human dental oral craniofacial diseases with cardiovascular diseases using machine learning approaches. Clin Oral Invest. 2024;28(1):52. https://doi.org/10.1007/s00784-023-05406-3

    Article 

    Google Scholar
     

  • Ahmed Z, Wan S, Zhang F, Zhong W. Artificial intelligence for omics data analysis. BMC Methods. 2024;1(4). https://doi.org/10.1186/s44330-024-00004-5



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