Scientific Papers

The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study | Alzheimer’s Research & Therapy


  • Scheltens P, Blennow K, Breteler MMB, de Strooper B, Frisoni GB, Salloway S, et al. Alzheimer’s disease. Lancet. 2016;388(10043):505–17.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Chételat G, Arbizu J, Barthel H, Garibotto V, Law I, Morbelli S, et al. Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer’s disease and other dementias. The Lancet Neurology. Volume 19. Lancet Publishing Group; 2020. pp. 951–62.

  • Scheltens NME, van der Weijden K, Adriaanse SM, van Assema D, Oomen PP, Krudop WA, et al. Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer’s disease. Neuroimage Clin. 2018;19:625–32.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Beach TG, Monsell SE, Phillips LE, Kukull W. Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease centers, 2005–2010. J Neuropathol Exp Neurol. 2012;71(4):266–73.

    Article 
    PubMed 

    Google Scholar
     

  • Karanth S, Nelson PT, Katsumata Y, Kryscio RJ, Schmitt FA, Fardo DW, et al. Prevalence and clinical phenotype of Quadruple misfolded proteins in older adults. JAMA Neurol. 2020;77(10):1299–307.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Robinson JL, Richardson H, Xie SX, Suh E, Van Deerlin VM, Alfaro B, et al. The development and convergence of co-pathologies in Alzheimer’s disease. Brain. 2021;144(3):953–62.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Barker WW, Luis CA, Kashuba A, Luis M, Harwood DG, Loewenstein D, et al. Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the state of Florida Brain Bank. Alzheimer Dis Assoc Disord. 2002;16(4):203–12.

    Article 
    PubMed 

    Google Scholar
     

  • Spina S, La Joie R, Petersen C, Nolan AL, Cuevas D, Cosme C, et al. Comorbid neuropathological diagnoses in early versus late-onset Alzheimer’s disease. Brain. 2021;144(7):2186–98.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Levin J, Baiardi S, Quadalti C, Rossi M, Mammana A, Vöglein J, et al. α-Synuclein seed amplification assay detects Lewy body co‐pathology in autosomal dominant Alzheimer’s disease late in the disease course and dependent on Lewy pathology burden. Alzheimer’s & Dementia. 2024;20(6):4351–4365.

  • Ossenkoppele R, Jansen WJ, Rabinovici GD, Knol DL, van der Flier WM, van Berckel BNM, et al. Prevalence of amyloid PET positivity in dementia syndromes. JAMA. 2015;313(19):1939.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FRJ, et al. Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. JAMA. 2015;313(19):1924–38.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TLS, et al. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer’s disease. Sci Transl Med. 2014;6(226):226ra30.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jack CR, Holtzman DM. Biomarker modeling of alzheimer’s disease. Volume 80. Neuron. Cell; 2013. pp. 1347–58.

  • Pichet Binette A, Franzmeier N, Spotorno N, Ewers M, Brendel M, Biel D, et al. Amyloid-associated increases in soluble tau is a key driver in accumulation of tau aggregates and cognitive decline in early Alzheimer. Nat Commun. 2022;13(1):6635.

  • Mattsson-Carlgren N, Andersson E, Janelidze S, Ossenkoppele R, Insel P, Strandberg O, et al. Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive tau PET in Alzheimer’s disease. Sci Adv. 2020;6(16):eaaz2387.

  • Ossenkoppele R, Jansen WJ, Rabinovici GD, Knol DL, van der Flier WM, van Berckel BNM, et al. Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis. JAMA. 2015;313(19):1939–49.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Therriault J, Vermeiren M, Servaes S, Tissot C, Ashton NJ, Benedet AL, et al. Association of phosphorylated tau biomarkers with amyloid Positron Emission Tomography vs Tau Positron Emission Tomography. JAMA Neurol. 2023;80(2):188.

    Article 
    PubMed 

    Google Scholar
     

  • Groot C, Smith R, Stomrud E, Binette AP, Leuzy A, Wuestefeld A, et al. Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals. Brain. 2023;146(4):1580–91.

    Article 
    PubMed 

    Google Scholar
     

  • Bouwman FH, Schoonenboom NSM, Verwey NA, van Elk EJ, Kok A, Blankenstein MA, et al. CSF biomarker levels in early and late onset Alzheimer’s disease. Neurobiol Aging. 2009;30(12):1895–901.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Ossenkoppele R, Reimand J, Smith R, Leuzy A, Strandberg O, Palmqvist S, et al. Tau PET correlates with different Alzheimer’s disease-related features compared to CSF and plasma p‐tau biomarkers. EMBO Mol Med. 2021;13(8):e14398.

  • Rabinovici GD, Knopman D, Arbizu J, Benzinger TLS, Donohoe KJ, Hansson O et al. Revised Criteria for Diagnosis and Staging of Alzheimer’s Disease: Alzheimer’s Association Workgroup. [cited 2024 May 2]; https://aaic.alz.org/diagnostic-criteria.asp

  • Fleisher AS, Pontecorvo MJ, Devous MD, Lu M, Arora AK, Truocchio SP, et al. Positron Emission Tomography Imaging with [ 18 F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes. JAMA Neurol. 2020;77(7):829.

    Article 
    PubMed 

    Google Scholar
     

  • Lowe VJ, Lundt ES, Albertson SM, Min HK, Fang P, Przybelski SA, et al. Tau-positron emission tomography correlates with neuropathology findings. Alzheimers Dement. 2020;16(3):561–71.

    Article 
    PubMed 

    Google Scholar
     

  • Soleimani-Meigooni DN, Iaccarino L, La Joie R, Baker S, Bourakova V, Boxer AL, et al. 18F-flortaucipir PET to autopsy comparisons in Alzheimer’s disease and other neurodegenerative diseases. Brain. 2020;143(11):3477–94.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yap SY, Frias B, Wren MC, Schöll M, Fox NC, Årstad E, et al. Discriminatory ability of next-generation tau PET tracers for Alzheimer’s disease. Brain. 2021;144(8):2284–90.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lowe VJ, Curran G, Fang P, Liesinger AM, Josephs KA, Parisi JE et al. An autoradiographic evaluation of AV-1451 tau PET in dementia. Acta Neuropathol Commun 2016;4(1).

  • Ossenkoppele R, Rabinovici GD, Smith R, Cho H, Scholl M, Strandberg O, et al. Discriminative accuracy of [18F]flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders. JAMA – J Am Med Association. 2018;320(11):1151–62.

    Article 
    CAS 

    Google Scholar
     

  • Jack CR, Wiste HJ, Botha H, Weigand SD, Therneau TM, Knopman DS, et al. The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes. Brain. 2019;142(10):3230–42.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pascoal TA, Therriault J, Benedet AL, Savard M, Lussier FZ, Chamoun M, et al. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain. 2020;143(9):2818–2830.

  • Leuzy A, Smith R, Ossenkoppele R, Santillo A, Borroni E, Klein G, et al. Diagnostic performance of RO948 F 18 Tau Positron Emission Tomography in the differentiation of Alzheimer Disease from Other Neurodegenerative disorders. JAMA Neurol. 2020;77(8):955–65.

    Article 
    PubMed 

    Google Scholar
     

  • Leuzy A, Pascoal TA, Strandberg O, Insel P, Smith R, Mattsson-Carlgren N, et al. A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis. Eur J Nucl Med Mol Imaging. 2021;48(7):2295–305.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, et al. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease. Brain. 2016;139(Pt 5):1551–67.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, et al. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016;79(1):110–9.

    Article 
    PubMed 

    Google Scholar
     

  • Macedo AC, Therriault J, Tissot C, Fernandez-Arias J, Ferreira PCL, Vitali P et al. Predicting functional decline in aging and Alzheimer’s disease with PET-based Braak staging. Brain Commun. 2024;6(2).

  • Tissot C, Therriault J, Pascoal TA, Chamoun M, Lussier FZ, Savard M et al. Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer’s disease. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. 2021;7(1).

  • Ossenkoppele R, Smith R, Ohlsson T, Strandberg O, Mattsson N, Insel PS, et al. Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease. Neurology. 2019;92(6):e601–12.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • La Joie R, Visani AV, Lesman-Segev OH, Baker SL, Edwards L, Iaccarino L, et al. Association of APOE4 and clinical variability in Alzheimer Disease with the pattern of tau- and Amyloid-PET. Neurology. 2021;96(5):e650–61.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ossenkoppele R, van der Kant R, Hansson O. Tau biomarkers in Alzheimer’s disease: towards implementation in clinical practice and trials. The Lancet Neurology. Volume 21. Elsevier Ltd; 2022. pp. 726–34.

  • Wolters EE, Dodich A, Boccardi M, Corre J, Drzezga A, Hansson O, et al. Clinical validity of increased cortical uptake of [18F]flortaucipir on PET as a biomarker for Alzheimer’s disease in the context of a structured 5-phase biomarker development framework. Eur J Nucl Med Mol Imaging. 2021;48(7):2097–109.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • De Wilde A, Van Der Flier WM, Pelkmans W, Bouwman F, Verwer J, Groot C, et al. Association of amyloid positron emission tomography with changes in diagnosis and patient treatment in an unselected memory clinic cohort: the ABIDE project. JAMA Neurol. 2018;75(9):1062–70.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zwan MD, Bouwman FH, Konijnenberg E, van der Flier WM, Lammertsma AA, Verhey FRJ, et al. Diagnostic impact of [18F]flutemetamol PET in early-onset dementia. Alzheimers Res Ther. 2017;9(1):2.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ossenkoppele R, Prins ND, Pijnenburg YAL, Lemstra AW, Van Der Flier WM, Adriaanse SF, et al. Impact of molecular imaging on the diagnostic process in a memory clinic. Alzheimer’s Dement. 2013;9(4):414–21.

    Article 

    Google Scholar
     

  • Shekari M, Verwer EE, Yaqub M, Daamen M, Buckley C, Frisoni GB, et al. Harmonization of brain PET images in multi-center PET studies using Hoffman phantom scan. EJNMMI Phys. 2023;10(1):68.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Coomans EM, de Koning LA, Rikken RM, Verfaillie SCJ, Visser D, den Braber A et al. Performance of a [ 18 F]flortaucipir PET visual read Method across the Alzheimer Disease Continuum and in Dementia with Lewy Bodies. Neurology. 2023;101(19).

  • van der Bij AK, de Weerd S, Cikot RJLM, Steegers EAP, Braspenning JCC. Validation of the Dutch short form of the State Scale of the Spielberger state-trait anxiety inventory: considerations for usage in screening outcomes. Public Health Genomics. 2003;6(2):84–7.

    Article 

    Google Scholar
     

  • Marteau TM, Bekker H. The development of a six-item short‐form of the state scale of the Spielberger State—trait anxiety inventory (STAI). Br J Clin Psychol. 1992;31(3):301–6.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Mishel MH, Braden CJ. Finding meaning: antecedents of uncertainty in illness. Nurs Res. 1988;37(2):98–103.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Nyman SR, Casey C, Polman R. Psychometric properties of the ICECAP-O Quality of Life Measurement Tool when Self-reported by community-dwelling older people with mild and moderate dementia. Alzheimer Dis Assoc Disord. 2021;35(4):356–9.

  • Arraras JI, Greimel E, Sezer O, Chie WC, Bergenmar M, Costantini A, et al. An international validation study of the EORTC QLQ-INFO25 questionnaire: an instrument to assess the information given to cancer patients. Eur J Cancer. 2010;46(15):2726–38.

    Article 
    PubMed 

    Google Scholar
     

  • Brehaut JC, O’Connor AM, Wood TJ, Hack TF, Siminoff L, Gordon E, et al. Validation of a decision regret scale. Med Decis Mak. 2003;23(4):281–92.

    Article 

    Google Scholar
     

  • Altomare D, Caprioglio C, Assal F, Allali G, Mendes A, Ribaldi F, et al. Diagnostic value of amyloid-PET and tau-PET: a head-to-head comparison. Eur J Nucl Med Mol Imaging. 2021;48:2200–2211.

  • Altomare D, Barkhof F, Caprioglio C, Collij LE, Scheltens P, Lopes Alves I, et al. Clinical effect of early vs late amyloid Positron Emission Tomography in Memory Clinic patients: the AMYPAD-DPMS Randomized Clinical Trial. JAMA Neurol. 2023;80(6):548–57.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Smith R, Hägerström D, Pawlik D, Klein G, Jögi J, Ohlsson T, et al. Clinical utility of tau Positron Emission Tomography in the diagnostic workup of patients with cognitive symptoms. JAMA Neurol. 2023;1;80(7):749–756.

  • Rabinovici GD, Gatsonis C, Apgar C, Chaudhary K, Gareen I, Hanna L, et al. Association of Amyloid Positron Emission Tomography with subsequent change in Clinical Management among Medicare Beneficiaries with mild cognitive impairment or dementia. JAMA – J Am Med Association. 2019;321(13):1286–94.

    Article 

    Google Scholar
     

  • van Maurik IS, Broulikova HM, Mank A, Bakker ED, de Wilde A, Bouwman FH, et al. A more precise diagnosis by means of amyloid PET contributes to delayed institutionalization, lower mortality, and reduced care costs in a tertiary memory clinic setting. Alzheimer’s Dement. 2023;19(5):2006–13.

    Article 

    Google Scholar
     

  • Shimohama S, Tezuka T, Takahata K, Bun S, Tabuchi H, Seki M et al. Impact of amyloid and tau PET on changes in diagnosis and patient management. Neurology. 2023;100(3).

  • Josephs KA, Tosakulwong N, Weigand SD, Graff-Radford J, Schwarz CG, Senjem ML et al. Flortaucipir PET uncovers relationships between tau and amyloid-β in primary age–related tauopathy and Alzheimer’s disease. Sci Transl Med. 2024;16(757).

  • Boccardi M, Dodich A, Albanese E, Gayet-Ageron A, Festari C, Ashton NJ, et al. The strategic biomarker roadmap for the validation of Alzheimer’s diagnostic biomarkers: methodological update. Eur J Nucl Med Mol Imaging. 2021;48(7):2070–85.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rabinovici GD, Knopman D, Arbizu J, Donohoe STL, Hansson KJ. O, 2024 AUC for amyloid and tau PET: updated appropriate use criteria for amyloid and tau PET in Alzheimer’s Disease. Butler Hospital Memory and Aging Program. 2024;17.



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