Holt LJ, Siddle K. Grb10 and Grb14: enigmatic regulators of insulin action-and more? Biochem J. 2005;388:393–406.
Holt LJ, Daly RJ. Adapter protein connections: The MRL and Grb7 protein families. Growth Factors. 2005;23:193–201.
Frantz JD, Giorgetti-peraldi S, Ottinger EA, Shoelson SE. Human GRB-IR β /GRB10. J Biol Chem. 1997;272:2659–67.
Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, Smith RJ. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem. 2003;278:31564–73.
Rodriguez-Viciana P, Sabatier C, McCormick F. Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol. 2004;24:4943–54.
Depetris RS, Wu J, Hubbard SR. Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Nat Struct Mol Biol. 2009;16:833–9.
Shen TL, Han DC, Guan JL. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. J Biol Chem. 2002;277:29069–77.
Li H, Sánchez-Torres J, Del Carpio AF, Nogales-González A, Molina-Ortiz P, Moreno MJ, et al. The adaptor Grb7 is a novel calmodulin-binding protein: Functional implications of the interaction of calmodulin with Grb7. Oncogene. 2005;24:4206–19.
García-Palmero I, Pompas-Veganzones N, Villalobo E, Gioria S, Haiech J, Villalobo A. The adaptors Grb10 and Grb14 are calmodulin-binding proteins. FEBS Lett. 2017;591:1176–86.
Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR. Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Mol Cell. 2005;20:325–33.
Desbuquois B, Carré N, Burnol AF. Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins. FEBS J. 2013;280:794–816.
Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011;332:1317–22.
Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science. 2011;332:1322–6.
Andergassen D, Dotter CP, Wenzel D, Sigl V, Bammer PC, Muckenhuber M, et al. Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. Elife. 2017;6 Xci:1–29.
Tucci V, Isles AR, Kelsey G, Ferguson-Smith AC, Bartolomei MS, Benvenisty N, et al. Genomic Imprinting and Physiological Processes in Mammals. Cell. 2019;176:952–65.
Blagitko N, Mergenthaler S, Schulz U, Wollmann HA, Craigen W, Eggermann T, et al. Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue-and isoform-specific fashion. Hum Mol Genet. 2000;9:1587–95.
Charalambous M, Smith FM, Bennett WR, Crew TE, Mackenzie F, Ward A. Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci U S A. 2003;100:8292–7.
Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, et al. Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature. 2011;469:534–40.
Dent C, Reinecker KDA, Ward A, Wilkins JF, Humby T, Isles AR. Mice lacking paternal expression of imprinted Grb10 are risk takers. Genes Brain Behav. 2020;19:e12679.
Dent CL, Humby T, Lewis K, Ward A, Fischer-Colbrie R, Wilkinson LS, et al. Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior. Genetics. 2018;209:233–9.
Rienecker KDA, Chavasse AT, Moorwood K, Ward A, Isles AR. Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance. Genes Brain Behav. 2020;19(1):e12571.
Madon-Simon M, Cowley M, Garfield AS, Moorwood K, Bauer SR, Ward A. Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes. BMC Biol. 2014;12:771.
Moorwood K, Smith FM, Garfield AS, Ward A. Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes. BMC Biol. 2024;22:127.
Mokbel N, Hoffman NJ, Girgis CM, Small L, Turner N, Daly RJ, et al. Grb10 Deletion Enhances Muscle Cell Proliferation, Differentiation and GLUT4 Plasma Membrane Translocation. J Cell Physiol. 2014;229:1753–64.
Holt LJ, Turner N, Mokbel N, Trefely S, Kanzleiter T, Kaplan W, et al. Grb10 regulates the development of fiber number in skeletal muscle. FASEB J. 2012;26:3658–69.
Smith FM, Holt LJ, Garfield AS, Charalambous M, Koumanov F, Perry M, et al. Mice with a Disruption of the Imprinted Grb10 Gene Exhibit Altered Body Composition, Glucose Homeostasis, and Insulin Signaling during Postnatal Life. Mol Cell Biol. 2007;27:5871–86.
Wang L, Balas B, Christ-Roberts CY, Kim RY, Ramos FJ, Kikani CK, et al. Peripheral Disruption of the Grb10 Gene Enhances Insulin Signaling and Sensitivity In Vivo. Mol Cell Biol. 2007;27:6497–505.
Liu B, Liu F. Feedback regulation of mTORC1 by Grb10 in metabolism and beyond. Cell Cycle. 2014;13:2643–4.
Zhang J, Zhang N, Liu M, Li X, Zhou L, Huang W, et al. Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis. Diabetes. 2012;61:3189–98.
Holt LJ, Brandon AE, Small L, Suryana E, Preston E, Wilks D, et al. Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice. Endocrinology. 2018;159:1339–51.
Liu H, He Y, Bai J, Zhang C, Zhang F, Yang Y, et al. Hypothalamic Grb10 enhances leptin signalling and promotes weight loss. Nat Metab. 2023;5:147–64.
Efstratiadis A. Genetics of mouse growth. Int J Dev Biol. 1998;42:955–76.
Cooney GJ, Lyons RJ, Crew AJ, Jensen TE, Molero JC, Mitchell CJ, et al. Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice. EMBO J. 2004;23:582–93.
Holt LJ, Lyons RJ, Ryan AS, Beale SM, Ward A, Cooney GJ, et al. Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis. Mol Endocrinol. 2009;23:1406–14.
Shen T-L, Guan J-L. Grb7 in intracellular signaling and its role in cell regulation. Front Biosci. 2004;9:192–200.
Chu PY, Tai YL, Shen TL. Grb7, a critical mediator of EGFR/ErbB signaling, in cancer development and as a potential therapeutic target. Cells. 2019;8:1–15.
Balogh K, Asa SL, Zheng L, Cassol C, Cheng S, Ezzat S. The insulin resistance Grb14 adaptor protein promotes thyroid cancer ret signaling and progression. Oncogene. 2012;31:4012–21.
Wang X, Cao Q, Shi Y, Wu X, Mi Y, Liu K, et al. Identification of low-dose radiation-induced exosomal circ-METRN and mir-4709-3p/GRB14/PDGFRα pathway as a key regulatory mechanism in glioblastoma progression and radioresistance: functional validation and clinical theranostic significance. Int J Biol Sci. 2021;17:1061–78.
Morzyglod L, Caüzac M, Popineau L, Denechaud PD, Fajas L, Ragazzon B, et al. Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma. Hepatology. 2017;65:1352–68.
Khan MI, Johani AA, Hamid A, Ateeq B, Manzar N, Adhami VM, et al. Proproliferative function of adaptor protein GRB10 in prostate carcinoma. FASEB J. 2019;33:3198–211.
Chen Y, Tang M, Xiong J, Gao Q, Cao W, Huang J. GRB10 is a novel oncogene associated with cell proliferation and prognosis in glioma. Cancer Cell Int. 2022;22:1–13.
Ren LL, Wang ZW, Sen R, Dai ZT, Liao XH, Shen LJ. GRB10 is a novel factor associated with gastric cancer proliferation and prognosis. Aging (Albany NY). 2023;15:3394–409.
Creighton CJ, Morgan M, Gunaratne PH, Wheeler DA, Gibbs RA, Robertson G, et al. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013;499:43–9.
Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice. PLoS Genet. 2015;11:1–25.
Prickett AR, Montibus B, Barkas N, Amante SM, Franco MM, Cowley M, et al. Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart. Front Cell Dev Biol. 2021;9:1–10.
Margolis B, Silvennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, et al. High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A. 1992;89:8894–8.
Leavey SF, Arend LJ, Dare H, Dressler GR, Briggs JP, Margolis BL. Expression of Grb7 growth factor receptor signaling protein in kidney development and in adult kidney. Am J Physiol. 1998;275(5):F770–6.
Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, et al. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell. 2022;185:1777–1792.e21.
Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell. 1993;75:73–82.
Louvi A, Accili D, Efstratiadis A. Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol. 1997;189:33–48.
Charalambous M, Cowley M, Geoghegan F, Smith FM, Radford EJ, Marlow BP, et al. Maternally-inherited Grb10 reduces placental size and efficiency. Dev Biol. 2010;337:1–8.
Lofgren KA, Kenny PA. Grb7 knockout mice develop normally but litters born to knockout females fail to thrive. Dev Dyn. 2023;253:677–89.
Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ, et al. Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup. PLoS Biol. 2014;12(2):e1001799.
Serpente P, Zhang Y, Islimye E, Hart-Johnson S, Gould AP. Quantification of fetal organ sparing in maternal low-protein dietary models. Wellcome Open Res. 2022;6:1–17.
Hartman HA, Lai HL, Patterson LT. Cessation of renal morphogenesis in mice. Dev Biol. 2007;310:379–87.
Pandey A, Duan H, Di Fiore PP, Dixit VM. The ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10. J Biol Chem. 1995;270:21461–3.
Pandey A, Liu X, Dixon JE, Di Fiore PP, Dixit VM. Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7. J Biol Chem. 1996;271:10607–10.
Costantini F, Shakya R. GDNF/Ret signaling and the development of the kidney. BioEssays. 2006;28:117–27.
Hyndman BD, Crupi MJF, Peng S, Bone LN, Rekab AN, Lian EY, et al. Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization. J Cell Sci. 2017;130:3282–96.
Eenjes E, Tibboel D, Wijnen RMH, Rottier RJ. Lung epithelium development and airway regeneration. Front Cell Dev Biol. 2022;10:1–11.
Cailliau K, Le Marcis V, Béréziat V, Perdereau D, Cariou B, Vilain JP, et al. Inhibition of FGF receptor signalling in Xenopus oocytes: Differential effect of Grb7, Grb10 and Grb14. FEBS Lett. 2003;548:43–8.
Riegl SD, Starnes C, Jima DD, Baptissart M, Diehl AM, Belcher SM, et al. The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease. Toxicol Sci. 2023;191:34–46.
Luo L, Jiang W, Liu H, Bu J, Tang P, Du C, et al. De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver. J Mol Endocrinol. 2018;60:285–97.
Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, et al. The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2022;7:851–61.
Popineau L, Morzyglod L, Carré N, Caüzac M, Bossard P, Prip-Buus C, et al. Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance. Mol Cell Biol. 2016;36:2168–81.
Chen Y, Du X, Kuppa A, Feitosa MF, Bielak LF, O’Connell JR, et al. Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease. Nat Genet. 2023;55(10):1640–50.
Cai Z, Liu F, Yang Y, Li D, Hu S, Song L, et al. GRB10 regulates β-cell mass by inhibiting β-cell proliferation and stimulating β-cell dedifferentiation. J Genet Genomics. 2022;49:208–16.
Prokopenko I, Poon W, Mägi R, Prasad BR, Salehi SA, Almgren P, et al. A central role for GRB10 in regulation of islet function in man. PLoS Genet. 2014;10(4):e1004235.
Itoh S, Taketomi A, Tanaka S, Harimoto N, Yamashita YI, Aishima SI, et al. Role of growth factor receptor-bound protein 7 in hepatocellular carcinoma. Mol Cancer Res. 2007;5:667–73.
Tanaka S, Pero SC, Taguchi K, Shimada M, Mori M, Krag DN, et al. Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis. J Natl Cancer Inst. 2006;98:491–8.
Gotovac JR, Liu DSH, Yates MJ, Milne JV, Macpherson AA, Simpson KJ, et al. GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma. J Pathol. 2020;252:317–29.
Pei YY, Ran J, Wen L, Liu X, Xiang L, Liu W, et al. Up-regulated GRB7 protein in gastric cancer cells correlates with clinical properties and increases proliferation and stem cell properties. Front Oncol. 2023;12:1–11.
Yu C, Luo D, Yu J, Zhang M, Zheng X, Xu G, et al. Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer. Oncogene. 2022;41:191–203.
Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, et al. Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Cell Metab. 2014;19:967–80.
Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, et al. Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci. PLoS Genet. 2013;9(8):e1003681.
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, et al. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genet. 2013;9(6):e100350.
Tybulewicz VLJ, Crawford CE, Jackson PK, Bronson RT, Mulligan RC. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell. 1991;65:1153–63.
Church GM, Gilbert W. Genomic sequencing. Proc Natl Acad Sci U S A. 1984;81(7):1991–5.
Charalambous M, Ward A, Hurst LD. Evidence for a priming effect on maternal resource allocation: Implications for interbrood competition. Proc R Soc B Biol Sci. 2003;270(SUPPL. 1):100–3.
Bancroft JD, Gamble M. Theory and Practice of Histological Techniques. 5th ed. London: Churchill Livingstone; 2002.
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