Scientific Papers

Oral mucosal changes caused by nicotine pouches: case series | Diagnostic Pathology


  • Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: results from the 2021 national survey on drug use and health. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2022. HHS Publication No. PEP22-07-01-005, NSDUH Series H-57.

  • Amaral AL, Lwaleed BA, Andrade SA. Electronic nicotine delivery systems (ENDS): a strategy for smoking cessation or a new risk factor for oral health? Evid Based Dent. 2023;24:188–9.

    Article 
    PubMed 

    Google Scholar
     

  • Amaral AL, da Costa Andrade PA, Lwaleed BA, et al. Impacts of smoking on oral health—what is the role of the dental team in smoking cessation? Evid Based Dent. 2023;24:186–7.

    Article 
    PubMed 

    Google Scholar
     

  • Amaral AL, da Costa Andrade PA, Lwaleed BA, et al. Tobacco dependence: a comprehensive guide to prevention and treatment. Evid Based Dent. 2023;24:150.

    Article 

    Google Scholar
     

  • Birdsey J, Cornelius M, Jamal A, Park-Lee E, Cooper MR, Wang J, et al. Tobacco product use among U.S. middle and high school students – national youth tobacco survey. MMWR Morb Mortal Wkly Rep. 2020;72:1173–82.

    Article 

    Google Scholar
     

  • Robichaud MO, Seidenberg AB, Byron MJ. Tobacco companies introduce ‘tobacco-free’ nicotine pouches. Tob Control. 2020;29–6.

  • Tattan-Birch H, Jackson SE, Dockrell M, Brown J. Tobacco-free nicotine pouch use in Great Britain: a representative population survey 2020–2021. Nicotine Tob Res. 2022;24:1509–12.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • U.S. Food & Drug Administration. Smokeless tobacco products, including dip, snuff, snus, and chewing tobacco. https://www.fda.gov/tobacco-products/products-ingredients-components/smokeless-tobacco-products-including-dip-snuff-snus-and-chewing-tobacco [Accessed 2024 Jun 19].

  • Jackson JM, Weke A, Holliday R. Nicotine pouches: a review for the dental team. Br Dent J. 2023;235:643–6.

    Article 

    Google Scholar
     

  • Nordic Spirit. Swedish snus vs nicotine pouches. https://nordicspirit.co.uk/blog/swedish-snus-vs-nicotine-pouches [Accessed 2024 Jun 19].

  • European Commission. Lack of EU regulation of nicotine pouches and a nicotine-addicted generation. https://www.europarl.europa.eu/doceo/document/E-9-2023-002498_EN.html [Accessed 2024 Jun 19].

  • Peeters S, Gilmore AB. Transnational tobacco company interests in smokeless tobacco in Europe: analysis of internal industry documents and contemporary industry materials. PLoS Med. 2013;10.

  • European Parliament. Lack of EU regulation of nicotine pouches and a nicotine-addicted generation. https://www.europarl.europa.eu/doceo/document/E-9-2023-002498_EN.html [Accessed 2024 Jun 19].

  • WHITECHEW. Kas ir nikotīna maisiņi? 2024. https://whitechew.com/lv/pages/kas-ir-nikotina-maisini [Accessed 2024 Jun 19].

  • Marynak KL, Jackson SL, King BA. Nicotine pouch unit sales in the US, 2016–2020. JAMA. 2021;326:566–8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Morean ME, Gueorguieva R, O’Malley S, Krishnan-Sarin S. Including the term ‘tobacco-free nicotine’ in the nicotine addiction warning label mandated by the US Food and Drug Administration alters risk perceptions and use intentions. Tob Control. 2024. https://doi.org/10.1136/tc-2023-058133 [Accessed 2024 Jun 19].

  • Taghavi S, et al. Nicotine content of domestic cigarettes, imported cigarettes and pipe tobacco in Iran. Addict Health. 2012;4:28–35.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mallock N et al. Levels of nicotine and tobacco-specific nitrosamines in oral nicotine pouches. Tob Control. https://doi.org/10.1136/tc-2022-057280 [Accessed 2024 Jun 19].

  • Campbell C et al. Designing studies to inform tobacco harm reduction: learnings from an oral nicotine pouch actual use pilot study. JMIR Form Res. 2022;6.

  • Prochaska JJ, Vogel EA, Benowitz N. Nicotine delivery and cigarette equivalents from vaping a JUULpod. Tob Control. 2022;31–93.

  • Hrywna M, Bover-Manderski MT, Wackowski OA, Steinberg MB, Delnevo CD. US physicians’ self-reported discussions about tobacco-free nicotine pouches during clinical encounters with patients in 2021. JAMA Netw Open. 2023;6.

  • Azzopardi D, Liu C, Murphy J. Chemical characterization of tobacco-free modern oral nicotine pouches and their position on the toxicant and risk continuums. Drug Chem Toxicol. 2022;45:2246–54.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shaikh SB, et al. Flavor classification/categorization and differential toxicity of oral nicotine pouches (ONPs) in oral gingival epithelial cells and bronchial epithelial cells. Toxics. 2022;10:660.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dowd AN et al. A cross-sectional survey on oral nicotine pouches: characterizing use-motives, topography, dependence levels, and adverse events. Nicotine Tob Res. 2023;ntad179. https://doi.org/10.1093/ntr/ntad179 [Accessed 2024 Jun 19].

  • Jabba SV et al. Synthetic cooling agent in oral nicotine pouch products marketed as ‘flavour-ban approved’. Tob Control. https://doi.org/10.1136/tc-2023-058035 [Accessed 2024 Jun 19].

  • Pedroso CM, et al. Pan-american prevalence of smokeless tobacco use and association with oral potentially malignant disorders and head and neck cancer: a systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023;136:322–32.

    Article 
    PubMed 

    Google Scholar
     

  • Rinaldi S, et al. Oral nicotine pouches with an aftertaste? Part 2: in vitro toxicity in human gingival fibroblasts. Arch Toxicol. 2023;97:2343–56.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hua M, et al. Identification of cytotoxic flavor chemicals in top-selling electronic cigarette refill fluids. Sci Rep. 2019;9:2782.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Samatha Y, et al. Clinicopathologic evaluation of lesions associated with tobacco usage. J Contemp Dent Pract. 2014;15:466–72.

    Article 
    PubMed 

    Google Scholar
     

  • De Geus JL, Wambier L, Loguercio AD, Reis A. The smokeless tobacco habit and DNA damage: a systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2019;24:55.


    Google Scholar
     

  • Dagli AF, et al. Cytological and cytomorphometric characteristics of buccal mucosa cells from smokeless tobacco users. Diagn Cytopathol. 2017;45:976–82.

    Article 
    PubMed 

    Google Scholar
     

  • Kopra E, et al. Systemic antibiotics influence periodontal parameters and oral microbiota, but not serological markers. Front Cell Infect Microbiol. 2021;11:774665.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ramos ESM, Martins NR, Kroumpouzos G. Oral and vulvovaginal changes in pregnancy. Clin Dermatol. 2016;34:353–8.

    Article 

    Google Scholar
     

  • Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002;52:195–215.

    Article 
    PubMed 

    Google Scholar
     

  • British Society of Periodontology. Basic periodontal examination (BPE). https://www.bsperio.org.uk/assets/downloads/BSP_BPE_Guidelines_2019.pdf [Accessed 2024 Jun 19].

  • Smoking and Nicotine Cessation Brochure. https://esparveselibu.lv/sites/default/files/inline-files/Rokasgramata-arstiem-smekesanas-atmesanai.pdf [Accessed 2024 Jun 19].

  • Müller S. Frictional keratosis, contact keratosis and smokeless tobacco keratosis: features of reactive white lesions of the oral mucosa. Head Neck Pathol. 2011;13:16–24.

    Article 

    Google Scholar
     

  • Greer RO. Oral manifestations of smokeless tobacco use. Otolaryngol Clin North Am. 2019;44:31–56.

    Article 

    Google Scholar
     

  • Ramasamy J, Sivapathasundharam B. A study on oral mucosal changes among tobacco users. J Oral Maxillofac Pathol. 2021;25:4707.

    Article 

    Google Scholar
     

  • Kopperud SE, Ansteinsson V, Mdala I, Becher R, Valen H. Oral lesions associated with daily use of snus, a moist smokeless tobacco product. A cross-sectional study among Norwegian adolescents. Acta Odontol Scand. 2023;81:473–8.

    PubMed 

    Google Scholar
     

  • Woo SB. Oral epithelial dysplasia and premalignancy. Head Neck Pathol. 2019;13:423–39.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shirani S, Kargahi N, Razavi SM, Homayoni SE. Epithelial dysplasia in oral cavity. Iran J Med Sci. 2014;39:406–17.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jain A, Chandurkar KP, Umale V, Srivastava R. Dysplasia in oral cavity: a review. Int J Adv Health Sci. 2014;1:12–9.


    Google Scholar
     

  • McKinney R, Olmo H. Physical and Chemical Lesions of the oral mucosa. StatPearls Publishing; 2024.

  • Reibel J, Gale N, Hille J. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of Tumours of the Head and Neck. Lyon: IARC; 2017.


    Google Scholar
     

  • Pulcini R, D’Agostino S, Dolci M, Bissioli A, Caporaso L, Iarussi F. The impact of COVID-19 on oral Cancer diagnosis: a systematic review. J Multidiscip Appl Nat Sci. 2022;2(2):65–9. https://doi.org/10.47352/jmans.2774-3047.110.

    Article 

    Google Scholar
     

  • Lo Giudice G, Colella G, Boschetti CE, Colella C, Tartaro G, Cirillo N. Increased delay in diagnosis, but not treatment, among patients with oral cancer during the COVID-19 pandemic. JAMA Otolaryngol Head Neck Surg. 2023;149(1):91–2. https://doi.org/10.1001/jamaoto.2022.36.

    Article 
    PubMed 

    Google Scholar
     

  • Mu G, et al. Association between smokeless tobacco use and oral cavity cancer risk in women compared with men: a systematic review and meta-analysis. BMC Cancer. 2021;21:960.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Martin GC, Brown JP, Eifler CW, Houston GD. Oral leukoplakia status six weeks after cessation of smokeless tobacco use. J Am Dent Assoc. 1999;130:945–54.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Binmadi N, et al. Oral lesions associated with smokeless tobacco users in Saudi Arabia: single center cross-sectional study. Saudi Dent J. 2022;34:114–20.

    Article 
    PubMed 

    Google Scholar
     

  • NHS. Oral epithelial dysplasia. https://mft.nhs.uk/app/uploads/sites/3/2018/09/UDH-89.pdf [accessed 2024 Jun 19].

  • Tobacco Tactics. Nicotine pouches. https://tobaccotactics.org/article/nicotine-pouches/ [accessed 2024 Jun 19].

  • Alizadehgharib S, Lehrkinder A, Alshabeeb A, Östberg AK, Lingström P. The effect of a non-tobacco-based nicotine pouch on mucosal lesions caused by Swedish smokeless tobacco (snus). Eur J Oral Sci. 2022;130.

  • McEwan M, et al. A randomised study to investigate the nicotine pharmacokinetics of oral nicotine pouches and a combustible cigarette. Eur J Drug Metab Pharmacokinet. 2022;47:211–21.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chapman F, et al. A randomised, open-label, cross-over clinical study to evaluate the pharmacokinetic, pharmacodynamic and safety and tolerability profiles of tobacco-free oral nicotine pouches relative to cigarettes. Psychopharmacology. 2022;239:2931–43.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mantey DS, Omega-Njemnobi O, Montgomery L. Flavored tobacco use is associated with dual and poly tobacco use among adolescents. Addict Behav. 2019;93:269–73.

    Article 
    PubMed 

    Google Scholar
     

  • Ye D, Rahman I. Emerging oral nicotine products and periodontal diseases. Int J Dent. 2023;9437475.

  • Cwalina SN, Majmundar A, Unger JB, Barrington-Trimis JL, Pentz MA. Adolescent menthol cigarette use and risk of nicotine dependence: findings from the national population assessment on tobacco and health (PATH) study. Drug Alcohol Depend. 2020;206:107715.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ling PM, Hrywna M, Talbot EM, Lewis MJ. Tobacco-derived nicotine pouch brands and marketing messages on internet and traditional media: content analysis. JMIR Form Res. 2023;7.

  • Wilson D, Wakefield M, Owen N, Roberts L. Characteristics of heavy smokers. Prev Med. 1992;21:311–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • VELO Nicotine pouch online shop. https://www.velo.com/lv/lv/ [accessed 2024 Jun 19].

  • Snusdirect.eu online shop. Available from: https://www.snusdirect.eu/zyn?gad_source=1gclid=Cj0KCQiAy9msBhD0ARIsANbk0A9oTKBdOU0l4YunT21QYTtIDtMmO0WKpiN2f0144b4rG024pl4bqwYaAtkrEALw_wcB [accessed 2024 Jun 19].

  • Schievelbein H, Eberhardt R, Löschenkohl K, Rahlfs V, Bedall FK. Absorption of nicotine through the oral mucosa. I. Measurement of nicotine concentration in the blood after application of nicotine and total particulate matter. Agents Actions. 1973;3:254–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Trybek G, et al. The effect of nicotine on oral health. Balt J Health Phys Act. 2018;10:7–13.

    Article 

    Google Scholar
     

  • Stanfill S, et al. Characterization of total and unprotonated (free) nicotine content of nicotine pouch products. Nicotine Tob Res. 2021;23:1590–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Solhi M, et al. The reasons for using smokeless tobacco: a review. Iran J Public Health. 2021;50:492–501.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Calafat AM, et al. Determination of tar, nicotine, and carbon monoxide yields in the mainstream smoke of selected international cigarettes. Tob Control. 2004;13:45–51.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bundesinstitut für Risikobewertung. Health Risk Assessment of Nicotine pouches: updated BfR Opinion No. 023/2022 of 7 October 2022. BfR-Stellungnahmen; 2022.

  • Kim K, Picciotto MR. Nicotine addiction: more than just dopamine. Curr Opin Neurobiol. 2023;83:102797.

    Article 
    CAS 
    PubMed 

    Google Scholar
     



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