Scientific Papers

Cooling during transportation of newborns with hypoxic ischemic encephalopathy using phase change material mattresses in low-resource settings: a randomized controlled trial in Hanoi, Vietnam | BMC Pediatrics


  • Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the sustainable development goals. Lancet. 2016;388(10063):3027–35.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • WHO-MCEE estimates for child causes of death, 2000–2015. Available from: http://www.who.int/healthinfo/global_burden_disease/estimates_child_cod_2015/.

  • Nga NT, Hoa DTP, Målqvist M, Persson LÅ, Ewald U. Causes of neonatal death: results from NeoKIP community-based trial in Quang Ninh province, Vietnam. Acta Paediatr. 2012;101(4):368–73.

    Article 
    PubMed 

    Google Scholar
     

  • Kea Dung. Resuscitation and morbidity patterns of neonatal emergency, deaths in Lao Cai province. Vietnam J Pediatr. 2021;13(6):28–34.


    Google Scholar
     

  • Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013;2013(1):Cd003311.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, et al. Therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy. Curr Neurol Neurosci Rep. 2019;19(2):2.

    Article 
    PubMed 

    Google Scholar
     

  • Montaldo P, Pauliah SS, Lally PJ, Olson L, Thayyil S. Cooling in a low-resource environment: lost in translation. Semin Fetal Neonatal Med. 2015;20(2):72–9.

    Article 
    PubMed 

    Google Scholar
     

  • Thayyil S, Pant S, Montaldo P, Shukla D, Oliveira V, Ivain P, et al. Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh. Lancet Glob Health. 2021;9(9):e1273–85.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gunn AJ, Gunn TR, Gunning MI, Williams CE, Gluckman PD. Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep. Pediatrics. 1998;102(5):1098–106.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Thoresen M, Tooley J, Liu X, Jary S, Fleming P, Luyt K, et al. Time is brain: starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns. Neonatology. 2013;104(3):228–33.

    Article 
    PubMed 

    Google Scholar
     

  • Smit E, Liu X, Jary S, Cowan F, Thoresen M. Cooling neonates who do not fulfil the standard cooling criteria – short- and long-term outcomes. Acta Paediatr. 2015;104(2):138–45.

    Article 
    PubMed 

    Google Scholar
     

  • Lumba R, Mally P, Espiritu M, Wachtel EV. Therapeutic hypothermia during neonatal transport at Regional Perinatal Centers: active vs. passive cooling. J Perinat Med. 2019;47(3):365–9.

    Article 
    PubMed 

    Google Scholar
     

  • Akula VP, Joe P, Thusu K, Davis AS, Tamaresis JS, Kim S, et al. A randomized clinical trial of therapeutic hypothermia mode during transport for neonatal encephalopathy. J Pediatr. 2015;166(4):856-1.e1-2.

    Article 
    PubMed 

    Google Scholar
     

  • Kendall GS, Kapetanakis A, Ratnavel N, Azzopardi D, Robertson NJ. Passive cooling for initiation of therapeutic hypothermia in neonatal encephalopathy. Arch Dis Child. 2010;95(6):F408–12.

    Article 

    Google Scholar
     

  • Chaudhary R, Farrer K, Broster S, McRitchie L, Austin T. Active versus passive cooling during neonatal transport. Pediatrics. 2013;132:841–6.

    Article 
    PubMed 

    Google Scholar
     

  • Torre Monmany N, Behrsin J, Leslie A. Servo-controlled cooling during neonatal transport for babies with hypoxic-ischaemic encephalopathy is practical and beneficial: experience from a large UK neonatal transport service. J Paediatr Child Health. 2019;55(5):518–22.

    Article 
    PubMed 

    Google Scholar
     

  • Thomas N, Abiramalatha T, Bhat V, Varanattu M, Rao S, Wazir S, et al. Phase changing material for therapeutic hypothermia in neonates with hypoxic ischemic encephalopathy – a multi-centric study. Indian Pediatr. 2018;55(3):201–5.

    Article 
    PubMed 

    Google Scholar
     

  • Aker K, Støen R, Eikenes L, Martinez-Biarge M, Nakken I, Håberg AK, et al. Therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy in India (THIN study): a randomised controlled trial. Arch Dis Child. 2020;105(4):405–11.

    Article 

    Google Scholar
     

  • Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, et al. Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr. 2011;159(5):851-8.e1.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Thayyil S, Shankaran S, Wade A, Cowan FM, Ayer M, Satheesan K, et al. Whole-body cooling in neonatal encephalopathy using phase changing material. Arch Dis Child Fetal Neonatal Ed. 2013;98(3):F280–1.

    Article 
    PubMed 

    Google Scholar
     

  • Tran HTT, Le HTT, Tran HTP, Khu DTK, Lagercrantz H, Tran DM, Winbladh B, Hellström-Westas L, Alfvén T, Olson L. Hypothermic treatment for neonatal asphyxia in low-resource settings using phase-changing material-An easy to use and low-cost method. Acta Paediatr. 2021;110(1):85–93. https://doi.org/10.1111/apa.15331. Epub 2020 May 12.

  • Azzopardi D, Brocklehurst P, Edwards D, Halliday H, Levene M, Thoresen M, et al. The TOBY study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial. BMC Pediatr. 2008;8: 17.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Thompson CM, Puterman AS, Linley LL, Hann FM, Van der Elst CW, Molteno CD, Malan AF. The value of a scoring system for hypoxic-ischaemic encephalopathy in predicting neurodevelopmental outcome. Acta Pediatr. 1997;86:757.

    Article 
    CAS 

    Google Scholar
     

  • Tran HTT, Le HT, Tran DM, et al. Therapeutic hypothermia after perinatal asphyxia in Vietnam: mediumterm outcomes at 18 months – a prospective cohort study. BMJ Paediatrics Open. 2024;8:e002208. https://doi.org/10.1136/bmjpo-2023-002208.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353(15):1574–84.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ellis M, Manandhar N, Manandhar DS, Costello AM. Risk factors for neonatal encephalopathy in Kathmandu, Nepal, a developing country: unmatched case-control study. BMJ. 2000;320(7244):1229–36.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shankaran S, Pappas A, Laptook AR, McDonald SA, Ehrenkranz RA, Tyson JE, et al. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics. 2008;122(4):e791–8.

    Article 
    PubMed 

    Google Scholar
     

  • Tran DM, Larsson M, Olson L, Hoang NTB, Le NK, Khu DTK, et al. High prevalence of colonisation with carbapenem-resistant Enterobacteriaceae among patients admitted to Vietnamese hospitals: risk factors and burden of disease. J Infect. 2019;79(2):115–22.

    Article 
    PubMed 

    Google Scholar
     

  • Eklind S, Mallard C, Leverin AL, Gilland E, Blomgren K, Mattsby-Baltzer I, et al. Bacterial endotoxin sensitizes the immature brain to hypoxic–ischaemic injury. Eur J Neurosci. 2001;13(6):1101–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O’Sullivan F, Burton PR, et al. Intrapartum risk factors for newborn encephalopathy: the Western Australian case-control study. BMJ. 1998;317(7172):1554–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lemyre B, Ly L, Chau V, Chacko A, Barrowman N, Whyte H, et al. Initiation of passive cooling at referring centre is most predictive of achieving early therapeutic hypothermia in asphyxiated newborns. Paediatr Child Health. 2017;22(5):264–8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Davies A, Wassink G, Bennet L, Gunn AJ, Davidson JO. Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy? Neural Regen Res. 2019;14(10):1678–83.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lindsay NM, Healy GN, Colditz PB, Lingwood BE. Use of the ages and stages questionnaire to predict outcome after hypoxic-ischaemic encephalopathy in the neonate. J Paediatr Child Health. 2008;44(10):590–5.

    Article 
    PubMed 

    Google Scholar
     

  • Natarajan G, Pappas A, Shankaran S, Laptook AR, Walsh M, McDonald SA, et al. Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial. Pediatric research. 2012;72(4):414–9.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • O’Reilly D, Labrecque M, O’Melia M, Bacic J, Hansen A, Soul JS. Passive cooling during transport of asphyxiated term newborns. J Perinatol. 2013;33(6):435–40.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hallberg B, et al. Passive induction of hypothermia during transport of asphyxiated infants: a risk of excessive cooling. Acta Paediatr. 2009;98:942–6.

    Article 
    PubMed 

    Google Scholar
     

  • Suryanto U, Plummer V, Boyle M. EMS systems in lower-middle income countries: a literature review. Prehosp Disaster Med. 2017;32(1):64–70.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Aggarwal KC, Gupta R, Sharma S, Sehgal R, Roy MP. Mortality in newborns referred to tertiary hospital: an introspection. J Family Med Prim Care. 2015;4(3):435–8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fairchild K, Sokora D, Scott J, Zanelli S. Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU. J Perinatol. 2010;30(5):324–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     



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