Scientific Papers

Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway | Molecular Cancer


  • Xing M, Wang X, Kiken RA, He L, Zhang J-Y. Immunodiagnostic biomarkers for Hepatocellular Carcinoma (HCC): the first step in detection and treatment. Int J Mol Sci 2021; 22.

  • Bond MJG, Bolhuis K, Loosveld OJL, de Groot JWB, Droogendijk H, Helgason HH, et al. First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group. Lancet Oncol. 2023;24:757–71.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen L, Wang C, Sun H, Wang J, Liang Y, Wang Y, et al. The bioinformatics toolbox for circRNA discovery and analysis. Brief Bioinform. 2021;22:1706–28.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Du WW, Zhang C, Yang W, Yong T, Awan FM, Yang BB. Identifying and characterizing circRNA-Protein Interaction. Theranostics. 2017;7:4183–91.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sanger HL, Klotz G, Riesner D, Gross HJ, Kleinschmidt AK. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A. 1976;73:3852–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zaitseva GN, Kolesnikov AA, Shirshov AT. The genetic system of kinetoplasts in trypanosomatides. Mol Cell Biochem. 1977;14:47–54.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zang J, Lu D, Xu A. The interaction of circRNAs and RNA binding proteins: an important part of circRNA maintenance and function. J Neurosci Res. 2020;98:87–97.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shi Y, Jia X, Xu J. The new function of circRNA: translation. Clin Transl Oncol. 2020;22:2162–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li R, Jiang J, Shi H, Qian H, Zhang X, Xu W. CircRNA: a rising star in gastric cancer. Cell Mol Life Sci. 2020;77:1661–80.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen C-K, Cheng R, Demeter J, Chen J, Weingarten-Gabbay S, Jiang L et al. Structured elements drive extensive circular RNA translation. Mol Cell 2021; 81.

  • Stagsted LVW, O’Leary ET, Ebbesen KK, Hansen TB. The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals. Elife 2021; 10.

  • Shao Y, Li M, Yu Q, Gong M, Wang Y, Yang X, et al. CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy. Eur J Pharmacol. 2022;922:174915.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang J, Liu Y, Shi G. The circRNA-miRNA-mRNA regulatory network in systemic lupus erythematosus. Clin Rheumatol. 2021;40:331–9.

    Article 
    PubMed 

    Google Scholar
     

  • Xue C, Li G, Zheng Q, Gu X, Bao Z, Lu J, et al. The functional roles of the circRNA/Wnt axis in cancer. Mol Cancer. 2022;21:108.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kristensen LS, Jakobsen T, Hager H, Kjems J. The emerging roles of circRNAs in cancer and oncology. Nat Rev Clin Oncol. 2022;19:188–206.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhu G, Chang X, Kang Y, Zhao X, Tang X, Ma C et al. CircRNA: a novel potential strategy to treat thyroid cancer (review). Int J Mol Med 2021; 48.

  • Zhang H, Shen Y, Li Z, Ruan Y, Li T, Xiao B, et al. The biogenesis and biological functions of circular RNAs and their molecular diagnostic values in cancers. J Clin Lab Anal. 2020;34:e23049.

    Article 
    PubMed 

    Google Scholar
     

  • Su K, Yi Q, Dai X, Liu O. Circular RNA ITCH: an Emerging Multifunctional Regulator. Biomolecules 2022; 12.

  • Hill M, Tran N. miRNA interplay: mechanisms and consequences in cancer. Dis Model Mech 2021; 14.

  • Pardi N, Hogan MJ, Weissman D. Recent advances in mRNA vaccine technology. Curr Opin Immunol. 2020;65:14–20.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pisignano G, Michael DC, Visal TH, Pirlog R, Ladomery M, Calin GA. Going circular: history, present, and future of circRNAs in cancer. Oncogene. 2023;42:2783–800.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495:333–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 2013;19:141–57.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, et al. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 2016;7:11215.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu K, Yin N, Peng M, Stamatiades EG, Shyu A, Li P, et al. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science. 2021;371:405–10.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu K, Yin N, Peng M, Stamatiades EG, Chhangawala S, Shyu A et al. Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses. Immunity 2021; 54.

  • Pan T, Sun S, Chen Y, Tian R, Chen E, Tan R, et al. Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis. Crit Care. 2022;26:29.

    Article 
    PubMed 

    Google Scholar
     

  • Paskeh MDA, Ghadyani F, Hashemi M, Abbaspour A, Zabolian A, Javanshir S, et al. Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: promises and challenges. Pharmacol Res. 2023;187:106553.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sun Y, Zhang H, Meng J, Guo F, Ren D, Wu H, et al. S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway. Cell Rep. 2022;40:111194.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Abdel-Megeed RM, Abd El-Alim SH, Arafa AF, Matloub AA, Farrag AERH, Darwish AB, et al. Crosslink among phosphatidylinositol-3 kinase/Akt, PTEN and STAT-5A signaling pathways post liposomal galactomannan hepatocellular carcinoma therapy. Toxicol Rep. 2020;7:1531–41.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shi H, Fang R, Li Y, Li L, Zhang W, Wang H, et al. The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells. Cancer Lett. 2016;382:147–56.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lu M, Hartmann D, Braren R, Gupta A, Wang B, Wang Y, et al. Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis. BMC Cancer. 2019;19:887.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Song R, Ma S, Xu J, Ren X, Guo P, Liu H, et al. A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR. Mol Cancer. 2023;22:16.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li J, Hu Z-Q, Yu S-Y, Mao L, Zhou Z-J, Wang P-C, et al. CircRPN2 inhibits aerobic glycolysis and metastasis in Hepatocellular Carcinoma. Cancer Res. 2022;82:1055–69.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yu T, Wang Y, Fan Y, Fang N, Wang T, Xu T, et al. CircRNAs in cancer metabolism: a review. J Hematol Oncol. 2019;12:90.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang F, Jiang J, Qian H, Yan Y, Xu W. Exosomal circRNA: emerging insights into cancer progression and clinical application potential. J Hematol Oncol. 2023;16:67.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dong W, Bi J, Liu H, Yan D, He Q, Zhou Q, et al. Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis. Mol Cancer. 2019;18:95.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu Q, Cao G, Wan Y, Xu C, He Y, Li G. Hsa_circ_0001073 targets miR-626/LIFR axis to inhibit lung cancer progression. Environ Toxicol. 2021;36:1052–60.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Goodall GJ, Wickramasinghe VO. RNA in cancer. Nat Rev Cancer. 2021;21:22–36.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu C-X, Chen L-L. Circular RNAs: characterization, cellular roles, and applications. Cell. 2022;185:2016–34.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li X, Yang L, Chen L-L. The Biogenesis, functions, and challenges of Circular RNAs. Mol Cell. 2018;71:428–42.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang Y, Yujiao W, Fang W, Linhui Y, Ziqi G, Zhichen W, et al. The roles of miRNA, lncRNA and circRNA in the development of osteoporosis. Biol Res. 2020;53:40.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu W, Cao L, Jia Y, Xiao Y, Zhang X, Gui S. Emerging roles of miRNA, lncRNA, circRNA, and their cross-talk in Pituitary Adenoma. Cells 2022; 11.

  • Ma B, Wang S, Wu W, Shan P, Chen Y, Meng J, et al. Mechanisms of circRNA/lncRNA-miRNA interactions and applications in disease and drug research. Biomed Pharmacother. 2023;162:114672.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mohanapriya R, Akshaya RL, Selvamurugan N. A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation. Biochimie. 2022;193:137–47.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tong K-L, Tan K-E, Lim Y-Y, Tien X-Y, Wong P-F. CircRNA-miRNA interactions in atherogenesis. Mol Cell Biochem. 2022;477:2703–33.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xu Y, Ke S, Lu S, Wang C, Li Z, Feng Z, et al. HLTF promotes hepatocellular carcinoma progression by enhancing SRSF1 stability and activating ERK/MAPK pathway. Oncogenesis. 2023;12:2.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Du D, Liu C, Qin M, Zhang X, Xi T, Yuan S, et al. Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. Acta Pharm Sin B. 2022;12:558–80.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Guo W, Yao X, Lan S, Zhang C, Li H, Chen Z, et al. Metabolomics and integrated network pharmacology analysis reveal SNKAF decoction suppresses cell proliferation and induced cell apoptisis in hepatocellular carcinoma via PI3K/Akt/P53/FoxO signaling axis. Chin Med. 2022;17:76.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee WY, Bachtiar M, Choo CCS, Lee CG. Comprehensive review of Hepatitis B Virus-associated hepatocellular carcinoma research through text mining and big data analytics. Biol Rev Camb Philos Soc. 2019;94:353–67.

    Article 
    PubMed 

    Google Scholar
     

  • Dietrich P, Koch A, Fritz V, Hartmann A, Bosserhoff AK, Hellerbrand C. Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance. Gut. 2018;67:1328–41.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ni Q, Chen Z, Zheng Q, Xie D, Li J-J, Cheng S, et al. Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway. Cancer Sci. 2020;111:1500–13.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu L, Gu M, Ma J, Wang Y, Li M, Wang H, et al. CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma. Mol Cancer. 2022;21:149.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sunagawa Y, Yamada S, Sonohara F, Kurimoto K, Tanaka N, Suzuki Y, et al. Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue. Sci Rep. 2021;11:6016.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     



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