Scientific Papers

14,15-Dihydroxyeicosatrienoic acid, a soluble epoxide hydrolase metabolite in blood, is a predictor of anthracycline-induced cardiotoxicity – a hypothesis generating study | Cardio-Oncology


  • Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17–48.

    Article 
    PubMed 

    Google Scholar
     

  • Thorn CF, Oshiro C, Marsh S, Hernandez-Boussard T, McLeod H, Klein TE, Altman RB. Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet Genomics. 2011;21:440–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ky B, Putt M, Sawaya H, French B, Januzzi JL Jr, Sebag IA, Plana JC, Cohen V, Banchs J, Carver JR, Wiegers SE, Martin RP, Picard MH, Gerszten RE, Halpern EF, Passeri J, Kuter I, Scherrer-Crosbie M. Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab. J Am Coll Cardiol. 2014;63:809–16.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ribeiro ML, Jorge AJL, Nacif MS, Martins WA. Early detection and monitoring of cancer chemotherapy-related left ventricular dysfunction by imaging methods. Ar Bras Cardiol. 2019;112:309–16.

    CAS 

    Google Scholar
     

  • Gent DG, Rebecca D. The 2022 European Society of Cardiology Cardio-oncology Guidelines in Focus. Eur Cardiol. 2023;21(18):e16.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Brown C, Mantzaris M, Nicolaou E, Karanasiou G, Papageorgiou E, Curigliano G, Cardinale D, Filippatos G, Memos N, Naka KK, Papakostantinou A, Vogazianos P, Ioulianou E, Shammas C, Constantinidou A, Tozzi F, Fotiadis DI, Antoniades A. A systematic review of miRNAs as biomarkers for chemotherapy-induced cardiotoxicity in breast cancer patients reveals potentially clinically informative panels as well as key challenges in miRNA research. Cardiooncology. 2022;8:16.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bär C, Chatterjee S, FalcãoPires I, Rodrigues P, Sluijter JPG, Boon RA, Nevado RM, Andrés V, Sansonetti M, de Windt L, Ciccarelli M, Hamdani N, Heymans S, FiguinhaVideira R, Tocchetti CG, Giacca M, Zacchigna S, Engelhardt S, Dimmeler S, Madonna R, et al. Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovasc Res. 2020;116(11):1805–19.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zordoky BN, Anwar-Mohamed A, Aboutabl ME, El-Kadi AO. Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats. Toxicol Appl Pharmacol. 2010;242:38–46.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Seidman A, Hudis C, Pierri MK, Shak S, Paton V, Ashby M, Murphy M, Stewart SJ, Keefe D. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol. 2002;20:1215–21.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ, Chamber Quantification Writing Group, American Society of Echocardiography’s Guidelines and Standards Committee, European Association of Echocardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–63.

    Article 
    PubMed 

    Google Scholar
     

  • Tse MM, Aboutabl ME, Althurwi HN, Elshenawy OH, Abdelhamid G, El-Kadi AO. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. Vascul Pharmacol. 2013;58:363–73.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang T, Peng R, Guo Y, Shen L, Zhao S, Xu D. The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. Lipids Health Dis. 2013;12:151.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Benite-Ribeiro SA, Lucas-Lima KL, dos Santos JM, Cagnini DQ, Guimarães IG. Early type 2 diabetes and obesity does not affect eicosanoids level and renal morphology in a rat model. Braz J Dev. 2021;7:85230–49.

    Article 

    Google Scholar
     

  • Reagan WJ, York M, Berridge B, Schultze E, Walker D, Pettit S. Comparison of cardiac troponin I and T, including the evaluation of an ultrasensitive assay, as indicators of doxorubicin-induced cardiotoxicity. Toxicol Pathol. 2013;41:1146–58.

    Article 
    PubMed 

    Google Scholar
     

  • Capdevila JH, Wang W, Falck JR. Arachidonic acid monooxygenase: genetic and biochemical approaches to physiological/pathophysiological relevance. Prostaglandins Other Lipid Mediat. 2015;120:40–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xiao B, Li X, Yan J, Yu X, Yang G, Xiao X, Voltz JW, Zeldin DC, Wang DW. Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide. J Pharmacol Exp Ther. 2010;334:784–94.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Inceoglu B, Jinks SL, Ulu A, Hegedus CM, Georgi K, Schmelzer KR, Wagner K, Jones PD, Morisseau C, Hammock BD. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proc Natl Acad Sci U S A. 2008;105:18901–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu P, Zhang S, Gao J, Lin Y, Shi G, He W, Touyz RM, Yan L, Huang H. Downregulated serum 14, 15-epoxyeicosatrienoic acid is associated with abdominal aortic calcification in patients with primary aldosteronism. Hypertension. 2018;71:592–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gauthier KM, Edwards EM, Falck JR, Reddy DS, Campbell WB. 14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries. Hypertension. 2005;45:666–71.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lin WK, Falck JR, Wong PY. Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats. Biochem Biophys Res Commun. 1990;167:977–81.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Imig JD, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nat Rev Drug Discov. 2009;8:794–805.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Santos JM, Park JA, Joiakim A, Putt DA, Taylor RN, Kim H. The role of soluble epoxide hydrolase in preeclampsia. Med Hypotheses. 2017;108:81–5.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Akasaka T, Sueta D, Arima Y, Tabata N, Takashio S, Izumiya Y, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Matsui K, Hokimoto S. Association of CYP2C19 variants and epoxyeicosatrienoic acids on patients with microvascular angina. Am J Physiol Heart Circ Physiol. 2016;311:H1409–15.

    Article 
    PubMed 

    Google Scholar
     

  • Pereira-Oliveira M, Reis-Mendes A, Carvalho F, Remião F, Bastos ML, Costa VM. Doxorubicin is key for the cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) combination in differentiated H9c2 cells. Biomolecules. 2019;9:21.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Alsaad AM, Zordoky BN, El-Sherbeni AA, El-Kadi AO. Chronic doxorubicin cardiotoxicity modulates cardiac cytochrome P450-mediated arachidonic acid metabolism in rats. Drug Metab Dispos. 2012;40:2126–35.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Qiu H, Li N, Liu JY, Harris TR, Hammock BD, Chiamvimonvat N. Soluble epoxide hydrolase inhibitors and heart failure. Cardiovasc Ther. 2011;29:99–111.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Dallons M, Schepkens C, Dupuis A, Tagliatti V, Colet JM. New insights about doxorubicin-induced toxicity to cardiomyoblast-derived H9C2 cells and dexrazoxane cytoprotective effect: contribution of in vitro1H-NMR metabonomics. Front Pharmacol. 2020;11:79.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Watkins SJ, Borthwick GM, Arthur HM. The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro. In Vitro Cell Dev Biol Anim. 2011;47:125–31.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gergely S, Hegedűs C, Lakatos P, Kovács K, Gáspár R, Csont T, Virág L. High throughput screening identifies a novel compound protecting cardiomyocytes from doxorubicin-induced damage. Oxid Med Cell Longev. 2015;2015:178513.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gasser A, Chen YW, Audebrand A, Daglayan A, Charavin M, Escoubet B, Karpov P, Tetko I, Chan MWY, Cardinale D, Désaubry L, Nebigil CG. Prokineticin receptor-1 signaling inhibits dose- and time-dependent anthracycline-Induced cardiovascular toxicity via myocardial and vascular protection. JACC CardioOncol. 2019;1:84–102.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Florescu M, Cinteza M, Vinereanu D. Chemotherapy-induced cardiotoxicity. Maedica (Bucur). 2013;8(1):59–67.

    PubMed 

    Google Scholar
     

  • Barpe DR, Rosa DD, Froehlich PE. Pharmacokinetic evaluation of doxorubicin plasma levels in normal and overweight patients with breast cancer and simulation of dose adjustment by different indexes of body mass. Eur J Pharm Sci. 2010;41:458–63.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ndrepepa G. Myeloperoxidase – a bridge linking inflammation and oxidative stress with cardiovascular disease. Clin Chim Acta. 2019;493:36–51.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Edin ML, Hamedani BG, Gruzdev A, Graves JP, Lih FB, Arbes SJ 3rd, Singh R, Orjuela Leon AC, Bradbury JA, DeGraff LM, Hoopes SL, Arand M, Zeldin DC. Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia. J Biol Chem. 2018;293:3281–92.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen D, Whitcomb R, MacIntyre E, Tran V, Do ZN, Sabry J, Patel DV, Anandan SK, Gless R, Webb HK. Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single- and multiple-dose studies in healthy human subjects. J Clin Pharmacol. 2012;52:319–28.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Galetta F, Franzoni F, Cervetti G, Cecconi N, Carpi A, Petrini M, Santoro G. Effect of epirubicin-based chemotherapy and dexrazoxane supplementation on QT dispersion in non-Hodgkin lymphoma patients. Biomed Pharmacother. 2005;59:541–4.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ducroq J, MohaouMaati H, Guilbot S, Dilly S, Laemmel E, Pons-Himbert C, Faivre JF, Bois P, Stücker O, Le Grand M. Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I(Ks). Br J Pharmacol. 2010;159:93–101.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wei X, Zhang D, Dou X, Niu N, Huang W, Bai J, Zhang G. Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. BMC Cancer. 2014;14:841.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Allison SE, Chen Y, Petrovic N, Zhang J, Bourget K, Mackenzie PI, Murray M. Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species. Biochem Pharmacol. 2017;143:79–89.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hoopes SL, Garcia V, Edin ML, Schwartzman ML, Zeldin DC. Vascular actions of 20-HETE. Prostaglandins Other Lipid Mediat. 2015;120:9–16.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     



  • Source link