Scientific Papers

White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum | Alzheimer’s Research & Therapy


  • Jack CR, et al. A/T/N: an unbiased descriptive classification scheme for Alzheimer disease biomarkers. Neurology. 2016;87(5):539–47.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82(4):239–59.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Aisen PS, et al. On the path to 2025: understanding the Alzheimer’s disease continuum. Alzheimers Res Ther. 2017;9(1):1–10.

    Article 

    Google Scholar
     

  • Fargo KN, Carrillo MC, Weiner MW, Potter WZ, Khachaturian Z. The crisis in recruitment for clinical trials in Alzheimer’s and dementia: an action plan for solutions. Alzheimers Dement. 2016;12(11):1113–5.

    Article 
    PubMed 

    Google Scholar
     

  • Gilmore-Bykovskyi AL, et al. Recruitment and retention of underrepresented populations in Alzheimer’s disease research: a systematic review. Alzheimers Dement. 2019;5:751–70.

    Article 

    Google Scholar
     

  • Kornblith E, Bahorik A, Boscardin WJ, Xia F, Barnes DE, Yaffe K. Association of race and ethnicity with incidence of dementia among older adults. JAMA. 2022;327(15):1488–95.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Miyashita A, Kikuchi M, Hara N, Ikeuchi T. Genetics of Alzheimer’s disease: an East Asian perspective. J Hum Genet. 2023;68(3):115–24. https://doi.org/10.1038/s10038-022-01050-z.

  • Hirschfeld LR, Risacher SL, Nho K, Saykin AJ. Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics. Transl Neurodegener. 2022;11(1):47. https://doi.org/10.1186/s40035-022-00321-1.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Bartzokis G. Alzheimer’s disease as homeostatic responses to age-related myelin breakdown. Neurobiol Aging. 2011;32(8):1341–71.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Bartzokis G, Lu PH, Mintz J. Human brain myelination and amyloid beta deposition in Alzheimer’s disease. Alzheimers Dement. 2007;3(2):122–5. https://doi.org/10.1016/j.jalz.2007.01.019.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Bubb EJ, Metzler-Baddeley C, Aggleton JP. The cingulum bundle: anatomy, function, and dysfunction. Neurosci Biobehav Rev. 2018;92:104–27.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Forno G, Lladó A, Hornberger M. Going round in circles—the Papez circuit in Alzheimer’s disease. Eur J Neurosci. 2021;54(10):7668–87.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Li W, et al. Aberrant functional connectivity in Papez circuit correlates with memory performance in cognitively intact middle-aged APOE4 carriers. Cortex. 2014;57:167–76.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • PichetBinette A, et al. Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer’s disease. Elife. 2021;10:e62929.

    Article 

    Google Scholar
     

  • Van Den Heuvel M, Mandl R, Luigjes J, Pol HH. Microstructural organization of the cingulum tract and the level of default mode functional connectivity. J Neurosci. 2008;28(43):10844–51.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mevel K, Chételat G, Eustache F, Desgranges B. The default mode network in healthy aging and Alzheimer’s disease. Int J Alzheimers Dis. 2011;2011:535816.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu M, Sporns O, Saykin AJ. The human connectome in Alzheimer disease—relationship to biomarkers and genetics. Nat Rev Neurol. 2021;17(9):545–63.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Bhatia KD, Henderson LA, Hsu E, Yim M. Reduced integrity of the uncinate fasciculus and cingulum in depression: a stem-by-stem analysis. J Affect Disord. 2018;235:220–8.

    Article 
    PubMed 

    Google Scholar
     

  • Mertse N, et al. Associations between anterior cingulate thickness, cingulum bundle microstructure, melancholia and depression severity in unipolar depression. J Affect Disord. 2022;301:437–44.

    Article 
    PubMed 

    Google Scholar
     

  • Li M, Wu F, Cao Y, Jiang X, Kong L, Tang Y. Abnormal white matter integrity in Papez circuit in first-episode medication-naive adults with anxious depression: a combined voxel-based analysis and region of interest study. J Affect Disord. 2023;324:489–95.

    Article 
    PubMed 

    Google Scholar
     

  • Van der Mussele S, et al. Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer’s disease. Int J Geriatr Psychiatry. 2013;28(9):947–58.

    Article 
    PubMed 

    Google Scholar
     

  • Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds CF. Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry. 2013;202(5):329–35.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bae JB, et al. Incidence of and risk factors for Alzheimer’s disease and mild cognitive impairment in Korean elderly. Dement Geriatr Cogn Disord. 2015;39(1–2):105–15.

    Article 
    PubMed 

    Google Scholar
     

  • Wu Y, Sun D, Wang Y, Wang Y, Ou S. Segmentation of the cingulum bundle in the human brain: a new perspective based on DSI tractography and fiber dissection study. Front Neuroanat. 2016;10:84.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Clark IA, Mohammadi S, Callaghan MF, Maguire EA. Conduction velocity along a key white matter tract is associated with autobiographical memory recall ability. Elife. 2022;11:e79303.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Soares J, Marques P, Alves V, Sousa N. A hitchhiker’s guide to diffusion tensor imaging. Front Neurosci. 2013;7:31.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Y, et al. Selective changes in white matter integrity in MCI and older adults with cognitive complaints. Biochim Biophys Acta. 2012;1822(3):423–30.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Wen Q, et al. White matter alterations in early-stage Alzheimer’s disease: a tract-specific study. Alzheimers Dement. 2019;11:576–87. https://doi.org/10.1016/j.dadm.2019.06.003.

    Article 

    Google Scholar
     

  • Choo IH, et al. Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer’s disease. Neurobiol Aging. 2010;31(5):772–9.

    Article 
    PubMed 

    Google Scholar
     

  • Gozdas E, Fingerhut H, Chromik LC, O’Hara R, Reiss AL, Hosseini S. Focal white matter disruptions along the cingulum tract explain cognitive decline in amnestic mild cognitive impairment (aMCI). Sci Rep. 2020;10(1):1–10.

    Article 

    Google Scholar
     

  • Liu Y, et al. Diffusion tensor imaging and tract-based spatial statistics in Alzheimer’s disease and mild cognitive impairment. Neurobiol Aging. 2011;32(9):1558–71.

    Article 
    PubMed 

    Google Scholar
     

  • Zhang Y, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology. 2007;68(1):13–9.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Dalboni da Rocha JL, Bramati I, Coutinho G, Tovar Moll F, Sitaram R. Fractional anisotropy changes in parahippocampal cingulum due to Alzheimer’s disease. Sci Rep. 2020;10(1):1–8.

    Article 

    Google Scholar
     

  • Zavaliangos-Petropulu A, et al. Diffusion MRI indices and their relation to cognitive impairment in brain aging: the updated multi-protocol approach in ADNI3. Front Neuroinform. 2019;13:2.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rieckmann A, Van Dijk KR, Sperling RA, Johnson KA, Buckner RL, Hedden T. Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer’s disease. Neurobiol Aging. 2016;42:177–88.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lin Y-C, et al. Cingulum correlates of cognitive functions in patients with mild cognitive impairment and early Alzheimer’s disease: a diffusion spectrum imaging study. Brain Topogr. 2014;27:393–402.

    Article 
    PubMed 

    Google Scholar
     

  • Mena PR, et al. The Alzheimer’s Disease Sequencing Project-Follow Up Study (ADSP-FUS): Increasing ethnic diversity in Alzheimer’s genetics research with the addition of potential new cohorts. Alzheimers Dement. 2021;17:e056101.


    Google Scholar
     

  • Chin AL, Negash S, Hamilton R. Diversity and disparity in dementia: the impact of ethnoracial differences in Alzheimer’s disease. Alzheimer Dis Assoc Disord. 2011;25(3):187.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Byun MS, et al. Korean brain aging study for the early diagnosis and prediction of Alzheimer’s disease: methodology and baseline sample characteristics. Psychiatry Investig. 2017;14(6):851.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Andersson JL, Sotiropoulos SN. An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Neuroimage. 2016;125:1063–78.

    Article 
    PubMed 

    Google Scholar
     

  • Andersson JL, Graham MS, Zsoldos E, Sotiropoulos SN. Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images. Neuroimage. 2016;141:556–72.

    Article 
    PubMed 

    Google Scholar
     

  • Smith SM, et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage. 2006;31(4):1487–505.

    Article 
    PubMed 

    Google Scholar
     

  • Mori S, Wakana S, Van Zijl PC, Nagae-Poetscher L. MRI atlas of human white matter. Amsterdam: Elsevier; 2005.

  • Klunk WE, et al. The Centiloid project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement. 2015;11(1):1–15. https://doi.org/10.1016/j.jalz.2014.07.003. e1-4.

    Article 
    PubMed 

    Google Scholar
     

  • Lee DY, et al. A normative study of the CERAD neuropsychological assessment battery in the Korean elderly. J Int Neuropsychol Soc. 2004;10(1):72–81.

    Article 
    PubMed 

    Google Scholar
     

  • Lee DY, Lee KU, Lee JH, Kim KW, Jhoo JH, Youn JC, Kim SY, Woo SI, Woo JI. A Normative Study of the Mini-Mental State Examination in the Korean Elderly. J Korean Neuropsychiatr Assoc. 2002;41(3):508–25.

  • Koenig KA, et al. The relationship between cognitive function and high-resolution diffusion tensor MRI of the cingulum bundle in multiple sclerosis. Mult Scler J. 2015;21(14):1794–801.

    Article 
    CAS 

    Google Scholar
     

  • Takahashi M, Iwamoto K, Fukatsu H, Naganawa S, Iidaka T, Ozaki N. White matter microstructure of the cingulum and cerebellar peduncle is related to sustained attention and working memory: a diffusion tensor imaging study. Neurosci Lett. 2010;477(2):72–6.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Charlton RA, Barrick TR, Lawes INC, Markus HS, Morris RG. White matter pathways associated with working memory in normal aging. Cortex. 2010;46(4):474–89.

    Article 
    PubMed 

    Google Scholar
     

  • Budde MD, Xie M, Cross AH, Song S-K. Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci. 2009;29(9):2805–13.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Song S-K, Sun S-W, Ramsbottom MJ, Chang C, Russell J, Cross AH. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage. 2002;17(3):1429–36.

    Article 
    PubMed 

    Google Scholar
     

  • Peters JM, et al. White matter mean diffusivity correlates with myelination in tuberous sclerosis complex. Ann Clin Transl Neurol. 2019;6(7):1178–90.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     



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