Scientific Papers

Editorial: Characterization of esophageal cancer molecular signatures and mechanisms using multi-omics analyses

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Cancer research is a constantly evolving field, driven by the synergy of cutting-edge technology, meticulous data analysis, and innovative methodologies. In this editorial, we explore recent studies that highlight the potential of modern approaches, such as machine learning and single-cell analysis, to decipher critical factors affecting the prognosis and treatment of various cancers. These groundbreaking insights provide new avenues for the enhancement of cancer diagnosis and the development of more effective therapies.

Esophageal squamous cell carcinoma (ESCC) poses a formidable challenge, demanding innovative insights (Shang et al.). Recent studies have leveraged machine learning techniques, revealing m6A regulators that show promise as prognostic indicators (Shang et al.). YTHDF1 and HNRNPC, in particular, offer a ray of hope for the development of more tailored and efficacious treatments for ESCC (Shang et al.). This urgency for innovative insights is especially palpable in the realm of ESCC, a challenging cancer that requires novel strategies for intervention (Shang et al.).

Tumor-associated macrophages (TAMs) with immunosuppressive properties can impede the effectiveness of immunotherapies (Li et al.). Recent investigations have uncovered a unique subpopulation of TAMs in ESCC, marked by the expression of TREM2 (Li et al.). These TREM2+ TAMs are closely associated with unfavorable clinical outcomes, making them not only potential predictive biomarkers for ESCC prognosis but also catalysts for refining immunotherapy strategies to enhance their effectiveness (Li et al.).

Genetic markers wield a profound influence on cancer susceptibility and prognostic outcomes (Zhong et al.). A recent investigation has delved deep into cell-type-specific expression quantitative trait loci (eQTL) within adenocarcinoma at the gastroesophageal junction (ACGEJ) (Zhong et al.). The results have unearthed a Research Topic of ACGEJ-specific eQTLs, shedding new light on susceptibility and prognosis markers tailored specifically to ACGEJ (Zhong et al.).

AURKA, a pivotal regulator of cell mitosis and tumor progression, remains relatively uncharted territory in terms of its prognostic significance across diverse cancer types (Yang et al.). However, a comprehensive analysis has now revealed that AURKA is prominently overexpressed in the majority of the cancer types under investigation (Yang et al.). This discovery paves the way for further exploration of AURKA’s potential as a predictive biomarker for a wide range of tumors (Yang et al.).

In conclusion, these studies collectively underscore the potential of contemporary analytical techniques to unveil the intricate molecular landscapes of cancer. They provide hope in the ongoing battle for a deeper understanding of cancer and the development of more effective treatments. As we progress in the realm of cancer research, it is crucial to remain vigilant for such groundbreaking discoveries and actively explore their potential clinical applications.

Author contributions

YX: Writing–review and editing. WH: Writing–review and editing. AT: Writing–original draft. YL: Writing–review and editing. GY: Writing–review and editing.

Conflict of interest

Author AT was employed by PerciaVista R&D Co.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: esophageal cancer, multi-omics analysis, machine learning, tumor-associated macrophages, Aurora Kinase A

Citation: Xu Y, Huang W, Tamadon A, Lin Y and Ye G (2023) Editorial: Characterization of esophageal cancer molecular signatures and mechanisms using multi-omics analyses. Front. Genet. 14:1334569. doi: 10.3389/fgene.2023.1334569

Received: 07 November 2023; Accepted: 15 November 2023;
Published: 21 November 2023.

Edited and reviewed by:

Anton A. Buzdin, European Organisation for Research and Treatment of Cancer, Belgium

Copyright © 2023 Xu, Huang, Tamadon, Lin and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Amin Tamadon,

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