Yang X, Wang R, Zhang S, et al. Polysaccharides from Panax japonicus C.A. Meyer and their antioxidant activities. Carbohydr Polym. 2014;101:386–91.
Morita T, Tanaka O, Kohda H. Saponin composition of rhizomes of Panax japonicus collected in South Kyushu, Japan, and its significance in oriental traditional medicine. Chem pharm bull. 1985;33:3852–8.
Zhang S, Wu Y, Jin J, et al. De novo characterization of Panax japonicus C. A. Mey transcriptome and genes related to triterpenoid saponin biosynthesis. Biochem Biophys Res Co. 2015;466(3):450–5.
Wang R, Chen P, Jia F, et al. Characterization and antioxidant activities of polysaccharides from Panax japonicus C.A. Meyer. Carbohydr Polym. 2012;88(4):1402–6.
You XL, Han JY, Choi YE. Plant regeneration via direct somatic embryogenesis in Panax japonicus. Plant Biotechnol Rep. 2007;1(1):5–9.
Ngan F, Shaw P, But P, et al. Molecular authentication of Panax species. Phytochemistry. 1999;50(5):787–91.
Xia P, Li J, Wang R, et al. Comparative study on volatile oils of four Panax genus species in Southeast Asia by gas chromatography–mass spectrometry. Ind Crops Prod. 2015;74:478–84.
Yoshizaki K, Devkota HP, Yahara S. Four new triterpenoid saponins from the leaves of Panax japonicus grown in southern Miyazaki Prefecture (4). Chem Pharm Bull. 2013;61(3):273–8.
Yoshizaki K, Devkota HP, Fujino H, et al. Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). Chem Pharm Bull. 2013;61(3):344–50.
Yoshizaki K, Murakami M, Fujino H, et al. New triterpenoid saponins from fruit specimens of Panax japonicus collected in Toyama Prefecture and Hokkaido (2). Chem Pharm Bull. 2012;60(6):728–35.
Ouyang LN, Xiang DW, Wu X, et al. Research progress on chemical constituents and pharmacological activities of Panax japonicus. Chin Tradit Herbal Drugs. 2010;41(6):1023–7.
Zhou M, Xu M, Zhu HT, et al. New dammarane-type saponins from the rhizomes of Panax japonicus. Helv Chim Acta. 2011;94(11):2010–9.
Tanaka K, Kubota M, Zhu S, et al. Analysis of ginsenosides in Ginseng drugs using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry. Nat Prod Commun. 2007;2(6):625–32.
Chen J, Tan M, Zou L, et al. Qualitative and quantitative analysis of the saponins in Panacis Japonici Rhizoma using ultra-fast liquid chromatography coupled with triple quadrupole-time of flight tandem mass spectrometry and ultra-fast liquid chromatography coupled with triple quadrupole-linear ion trap tandem mass spectrometry. Chem Pharm Bull. 2019;67(8):839–48.
Wu QS, Chen P, Zhang QW, et al. Advances in research of chemical constituents, pharmacological activities and analytical methods of Panax japonicus. Asia Pac Tradit Med. 2016;12(06):46–54.
Du Z, Li J, Zhang X, et al. An integrated LC-MS-based strategy for the quality assessment and discrimination of three Panax Species. Molecules. 2018;23(11):2988.
Chen JL, Tan MX, Zou LS, et al. Stimultaneous determination of multiple bioactive constituents in Panacis Japonici Rhizoma processed by different methods and grey relational analysis. Chin J of Chin Mater Med. 2018;43(21):4274–82.
Tanaka O, Morita T, Kasai R, et al. Study on saponins of rhizomes of Panax pseudo-ginseng subsp. himalaicus collected at Tzatogang and Pari-la, Bhutan-Himalaya. Chem Pharm Bull. 1985;33(6):2323–30.
Cai P, Xiao ZY, Wei JX. Chemical constituents of Panax japonicus (I). Chin Tradit Herbal Drugs. 1982;13(3):1–2.
Cai P, Xiao ZY. Chemical constituents of Panax japonicus (II). Chin Tradit Herbal Drugs. 1984;15(6):1–6.
Atopkina LN, Denisenko VA. Synthesis of 20S-protopanaxatriol β-d-glucopyranosides. Chem Nat Compd. 2019;55(1):82–7.
Jia L, Zhao Y. Current evaluation of the millennium phytomedicine–ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr Med Chem. 2009;16(19):2475.
Zou K, Zhu S, Meselhy MR, et al. Dammarane-type saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells. J Nat Prod. 2002;65(9):1288–92.
Zou K, Zhu S, Tohda C, et al. Dammarane-type triterpene saponins from Panax japonicus. J Nat Prod. 2002;65(3):346–51.
Huang Z, Huang Y, Li X, et al. Molecular mass and chain conformations of Rhizoma Panacis Japonici polysaccharides. Carbohydr Polym. 2009;78(3):596–601.
Huang Z, Zhang L. Chemical structures of water-soluble polysaccharides from Rhizoma Panacis Japonici. Carbohydr Res. 2009;344(9):1136–40.
Huang Z, Zhang L, Duan X, et al. Novel highly branched water-soluble heteropolysaccharides as immunopotentiators to inhibit S-180 tumor cell growth in BALB/c mice. Carbohyd Polym. 2012;87(1):427–34.
Meyer C, Zhang L, Zhang X, et al. Comparative analysis of the essential oils from normal and hairy roots of Panax japonicas C.A. Meyer. Afr J Biotechnol. 2011;10:2440–5.
Yang LB, Liu SJ, Da LL, et al. Research of fat-soluble components of Panax japonicus C. A. Mey. J Anhui Agric Sci. 2011;39(20):12145–6.
Chen L, Ren H, Xu R, et al. The effect of Fufang Zhujieshen tablets on inflammatory factors in osteoarthritis. Chin Hosp Pharm J. 2019;39(06):580–5.
Tan QL. The effects of anti -inflammatory of compound Panax japonicus Tablet in rheumatoid arthritis mice. Chin Med Herald. 2011;8(28):27–8.
Wang ZF, Tan QL, Zhang H, et al. Experimental studies on the mechanism of compound Japanese Ginseng pill in treatment of Rheumatoid arthritis. Lishizhen Med Mater Med Res. 2009;20(7):1611–3.
Wen DJ, Chen GD, Zhang CL, et al. Study on the anti-inflammatory effects of total Panax japonicus saponins. Lishizhen Med Mater Med Res. 2008;19(5):1155–6.
Deng L, Yuan D, Zhou Z, et al. Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. Neural Regen Res. 2017;12(11):1877–84.
Cheng ZH, Dun YY, Liu J, et al. Effects of saponins from Panax japonicus on colonic inflammation through Neu3/IAP signaling pathway in aging rats. Lishizhen Med Mater Med Res. 2019;30(7):1597–601.
Wang T, Dai Y, Dun Y, et al. Chikusetsusaponin V inhibits inflammatory responses via NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages. Immunopharm Immunot. 2014;36(6):404–11.
Yuan C, Liu C, Wang T, et al. Chikusetsu saponinIVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling. Oncotarget. 2017;8(19):31023.
Zhao QQ, Wang T, Yuang D, et al. Effect of Panax japonicus polysaccharide on LPS induced microglial inflammatory response. J Chin Med Mater. 2019;42(6):1409–12.
Duan L, Liu CQ, Wu LC, et al. Effects of Panax japonicus hypolipidemic compound on non-alcoholic fatty liver disease in mice and its mechanism. Med J Chin PLA. 2017;42(9):764–8.
Qin YE, Cui QQ, Zhang CC, et al. Effects of total saponins from Panax japonicus on acute hepatic injury induced by carbon tetrachloride. Chin J Inf Tradit Chin Med. 2014;21(10):47–9.
Qin YE, Zhang CC, Wang T, et al. Effect of polysaccharide from Panax japonicus on hepatic cell injury. Chin J Inf Tradit Chin Med. 2014;21(11):59–62.
Yang XL, Chen P. Protective Effects of polysaccharide and total Saponins from Panax japonicus on acute hepatic injury. Chin J Inf Tradit Chin Med. 2011;17(1):65–6.
Yuan D, Xiang T, Huo Y, et al. Preventive effects of total saponins of Panax japonicus on fatty liver fibrosis in mice. Arch Med Sci. 2018;14(2):396–406.
Dai YW, Zhang CC, Zhao HX, et al. Chikusetsusaponin V attenuates lipopolysaccharide-induced liver injury in mice. Immunopharm Immunot. 2016;38(3):167–74.
Xu R, Liu Z, Fu Q, et al. Protective effects of polysaccharides from Panax japonicus on mice with liver injury induced by acetaminophen. J South-Central Univ Nat (Nat Sci Ed). 2020;39(1):51–5.
Jiang SQ, Duan H, Shu GW, et al. Protective effects of polysaccharides from Panax japonicus on mice with acute liver injury induced by LPS/D-GalN. Chin Med Mat. 2017;40(5):1170–3.
Zhou Q, Duan L, Wu LC, et al. Experimental study of the protective effects of extracts of Panax japonica rhizoma, Salviae Miltiorrhiz radix Et Rhizoma and Crataegi Fructus compound on the hypolipidaemic in nonalcoholic fatty liver of mice. Chin J Clin Pharmacol. 2018;34(13):1532–5.
He ZG, Wang YP, Liu L, et al. Effects of Panax japonicus extractions on serum biochemical indices and inflammatory factors in mice with alcoholic liver injury. Zhejiang J Integr Tradit Chin West Med. 2018;28(1):21–4.
He HB, Xu J, Wang HW, et al. Effects of preconditioning with different fractions extracted from Panax japonicus C. A. Mey on acute myocardial ischemia in rats induced by ligation of left anterior descending branch. J Third Mil Med Univ. 2011;33(14):1462–6.
He H, Xu J, Xu Y, et al. Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats. J Ethnopharmacol. 2012;140(1):73–82.
Wei N, Zhang C, He H, et al. Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-κB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation. J Pharm Pharmacol. 2014;66(11):1641–51.
Wang L, Yuan D, Zheng J, et al. Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling. Phytomedicine. 2019;58:152764.
Zeng CH, Wang WS, Lu WJ, et al. Effects of Panax japonicus on the expression of Drd-2 and GFAP, TNF-α in hippocampus of AD Rats. Genomics Appl Biol. 2019;38(4):1560–5.
Zeng CH, Min Y, Lu WJ, et al. Effects of Panax japonicus on the expression of Inos, Arg-1, Aβ1-42, TNF-α in hippocampal microglia of AD Rats. Lishizhen Med Mater Med Res. 2018;29(9):2097–100.
Zhao H, Wang L, Zhang QX, et al. Effects of Panax japonicus on transmitter amino acid and free radical metabolism in vascular dementia rat. Chin J Gerontol. 2010;30(21):3096–8.
Wan JZ, Wang R, Zhou ZY, et al. Saponins of Panax japonicus confer neuroprotection against brain aging through mitochondrial related oxidative stress and autophagy in rats. Curr Pharm Biotechnol. 2020;21(8):667–80.
Wang T, Di G, Yang L, et al. Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats. J Pharm Pharmacol. 2015;67(9):1284–96.
Wan J, Deng L, Zhang C, et al. Chikusetsu saponin V attenuates H2O2– induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1α/Mn-SOD signaling pathways. Can J Physiol Pharm. 2016;94(9):919–28.
Fang X, Han Q, Li S, et al. Chikusetsu saponin IVa attenuates isoflurane-induced neurotoxicity and cognitive deficits via SIRT1/ERK1/2 in developmental rats. Am J Transl Res. 2017;9(9):4288–99.
Kim H, Lee H, Kim DJ, et al. Panax ginseng exerts antiproliferative effects on rat hepatocarcinogenesis. Nutr Res. 2013;33(9):753–60.
Zhu WB, Tian FJ, Liu LQ. Chikusetsu (CHI) triggers mitochondria-regulated apoptosis in human prostate cancer via reactive oxygen species (ROS) production. Biomed Pharmacother. 2017;90:446–54.
Zuo T, Zhang Z, Jiang P, Zhang R, et al. Characterization of chikusetsusaponinIV and V induced apoptosis in HepG2 cancer cells. Mol Biol Rep. 2022;49(6):4247–55.
Yuan D, Zuo R, Zhang CC. Effects of total saponins of Panax japonicus on human leukemic HL-60 cells. J Integr Med. 2007;5(5):570–2.
Zhang Y, Wang G, Zuo T, et al. Effects of Chikusetsusaponin IV, IVa and V on the proliferation, migration, invasion and apoptosis of human gastric cancer SGC-7901 cells. Tradit Chin Drug Res Clin Pharmacol. 2019;30(7):796–801.
Zhou ZY, Chen YX, Li DH, et al. Total saponins of Panax japonicus improve cancer cachexia in mice through inhibiting inflammatory response mediated by NF- κB. Chin Pharmacol Bull. 2018;34(4):532–7.
Shu G, Jiang S, Mu J, et al. Antitumor immunostimulatory activity of polysaccharides from Panax japonicus C. A. Mey: Roles of their effects on CD4+ T cells and tumor associated macrophages. Int J Biol Macromol. 2018;111:430–9.
Chen C, Wu W, Xu X, et al. Chain conformation and anti-tumor activity of derivatives of polysaccharide from Rhizoma Panacis Japonici. Carbohydr Polym. 2014;105:308–16.
Chen X, Wu Q, Meng F, et al. ChikusetsusaponinIVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells. Phytomedicine. 2016;23(13):1555–65.
Jiang HY, Deng QH, Zheng XH, et al. Effects of total saponins of Panax japonicus on apoptosis and activity of caspase-3 on A549 lung cancer cell. Sci Technol Eng. 2015;15(25):100–3.
Gao GZ, Zhang HR, Zhang T, et al. Study on the mechanism of saponins from Panax japonicus on inhition of A549 cell proliferation and migration through regulating PTEN/PI3K/Akt Pathway. Prog Mod Biomed. 2020;20(2):242–7.
Ni GF. Experimental study on antitumor activity of different extracts from Panax japonicus in vitro. Zhejiang J Tradit Chin Med. 2007;42(4):230–1.
Liu Y, Huang Z. Effect of water extract of Panax japonicus on apoptosis of cervical cancer Hela cells. Chin Tradit Pat Med. 2021;43(01):224–7.
Xi M, Hai C, Tang H, et al. Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytother Res. 2008;22(2):228–37.
Wang R, Chen P, Jia F, et al. Optimization of polysaccharides from Panax japonicus C.A. Meyer by RSM and its anti-oxidant activity. Int J Biol Macromol. 2012;50(2):331–6.
Zhang L, Zhao RF. Essential oil and antioxidant activity of tuber from Panax japonicus in Guizhou. Guizhou Agri Sci. 2010;38(6):44–6.
Ohtani K, Hatono S, Mizutani K, et al. Reticuloendothelial system-activating polysaccharides from rhizomes of Panax japonicas. I. Tochibanan-A and -B. Chem Pharm Bull. 1989;37(10):2587.
Zhang J, Li CY, Li JP, et al. Immunoregulation on mice of low immunity and effects on five kinds of human cancer cells of Panax japonicus polysaccharide. Evid-Based Compl Alt. 2015;2015:839697.
Zhang J, Li CY, Li JP, et al. Immunoregulative effects of Panax japonicus polysaccharide on mice of low immunity. In: 2014 China Pharmaceutical Conference and the 14th China Pharmacist Week Proceedings. 2014; 1–6.
Zhang CC, Zhao HX, Jiang MJ, et al. Effects of polysaccharides isolated from Panax japonicus on immunosuppression mice. J Chin Med Mater. 2011;34(1):91–4.
Zhang CC, Jiang MJ, Zhao HX, et al. Effects of total saponins of Panax japonicus Rhizoma on cyclophosphamide-in-duced immunosuppressed mice. Chin Tradit Pat Med. 2011;33(7):1134–8.
Wang HW, Jiang MJ, Zhao HX, et al. Immunomodulatory effects of saponin-polysaccharide and Panax japonicus composition on cyclophosphamide-induced immunosuppressed mice. Guangdong Med J. 2010;31(20):2620–2.
Yang BR, Yuen SC, Fan GY, et al. Identification of certain Panax species to be potential substitutes for Panax notoginseng in hemostatic treatments. Pharmacol Res. 2018;134:1–15.
Matsuda H, Samukawa KL, Fukuda S, et al. Studies of Panax japonicus fibrinolysis. Planta Med. 1989;55(1):18–21.
Dahmer T, Berger M, Barlette AG, et al. Antithrombotic effect of Chikusetsusaponin IVa isolated from Ilex paraguariensis (Mate). J Med Food. 2012;15(12):1073–80.
Zhang H, Wang HF, Liu Y, et al. The haematopoietic effect of Panax japonicus on blood deficiency model mice. J Ethnopharmacol. 2014;154(3):818–24.
Yang XL, Chen P, Wang RF, et al. Experimental study on the antihyperlipidemia effect of the polysaccharides of Panax japonicus in mice. Chin Hosp Pharm J. 2011;31(6):433–5.
Yang XL, Chen P. Experimental study on the anti hyperlipidemia effect of the total rhizoma Panacis japonica saponins. Acta Chin Med Pharmacol. 2010;38(6):22–4.
Han L, Zheng Y, Yoshikawa M, et al. Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. BMC Complem Altern M. 2005;5(1):9.
Ma QY, Zhang CC, Yang SQ, et al. Protective mechanism of saponins of Panax japonicus on high-fat diet induced reproductive dysfunction in mice. Chin Pharmacol Bull. 2019;35(10):1375–80.
Yamahara J, Kubomura Y, Miki K, et al. Anti-ulcer action of Panax japonicus rhizome. J Ethnopharmacol. 1987;19(1):95–101.
Mei Y, Xiao CC, Feng JW, et al. The preventive effect of total saponins of Panax japonicus on nonsteroidal anti-inflammatory drug-induced enteropathy. Chin J Cell Mol Immunol. 2016;32(6):734–8.
Borrelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res. 2000;14(8):581–91.
Wang T, Huang X, Zhai K, et al. Integrating metabolomics and network pharmacology to investigate Panax japonicus prevents kidney injury in HFD/STZ-induced diabetic mice. J Ethnopharmacol. 2023;303:115893.
Zhao H, Zhang QX, Mu Y. Effects of total rhizoma Panacis japonjica saponins (tRPJS) on nitric oxide synthase in hippocampus region following rat ischemic cerebral injury. Chin J Chin Mater Med. 2008;33(5):557–9.
Jia ZH, Zhao H. Effects of TSPJ on neuronal apoptosis and related gene expression in rat cerebral ischemia-reperfusion injury. Chin J Exp Tradit Med Form. 2011;17(21):168–72.
Zheng H, Qiu F, Zhao H, et al. Simultaneous determination of six bioactive saponins from Rhizoma Panacis Japonici in rat plasma by UHPLC-MS/MS: application to a pharmacokinetic study. J Chromatogr B. 2018;1092:199–206.
Qi D, Yang X, Chen J, et al. Determination of chikusetsusaponin V and chikusetsusaponinIV in rat plasma by liquid chromatography-mass spectrometry and its application to a preliminary pharmacokinetic study. Biomed Chromatogr. 2013;27(11):1568–73.
Xu C, Zhang CC, Li J, et al. Identification of Panax japonicus and its related plant species based on RAPD markers. Lishizhen Med Mate Med Res. 2016;27(1):101–4.
Chen JA, Yang L, Li RZ, et al. Identification of Panax japonicus and its related species or adulterants using ITS2 sequence. China Tradit Herb Drugs. 2018;49(15):3672–80.
Xia L, Liang YS, Li SL, et al. Comparative identification of Panax japonicus and its adulterant Sedum notoginseng. J Chin Med Mater. 2014;37(5):797–800.
Duan YM, Duan CL. Application of DNA molecular markers in the research of Panax Ginseng. Res Pract Chin Med. 2009;23(6):74–6.
Zhu S, Fushimi H, Komatsu K. Development of a DNA microarray for authentication of Ginseng drugs based on 18S rRNA gene sequence. J Agr Food Chem. 2008;56(11):3953–9.
Zhou M, Gong X, Pan Y. Panax species identification with the assistance of DNA data. Genet Resour Crop Ev. 2018;65(7):1839–56.
Cheng Y, Zou P, Zhang CF, et al. Development and validation of SSR markers based on transcriptome of Panax japonicus. J Chin Med Mater. 2017;40(12):2805–9.
Choi Y, Ahn CH, Kim B, et al. Development of species specific AFLP-derived SCAR marker for authentication of Panax japonicus C. A. MEYER. Biol Pharm Bull. 2008;31(1):135–8.
Nguyen VB, Linh Giang VN, Waminal NE, et al. Comprehensive comparative analysis of chloroplast genomes from seven Panax species and development of an authentication system based on species-unique single nucleotide polymorphism markers. J Ginseng Res. 2020;44(1):135–44.
Wu Q, Wang C, Lu J, et al. Simultaneous determination of six saponins in Panacis japonici rhizoma using quantitative analysis of multi-components with single-marker method. Curr Pharm Anal. 2017;13:289–95.
Meng F, Wu Q, Wang R, et al. A novel strategy for quantitative analysis of major ginsenosides in Panacis japonici rhizoma with a standardized reference fraction. Molecules. 2017;22(12):2067.
Wang XJ, Xie Q, Liu Y, et al. Panax japonicus and chikusetsusaponins: a review of diverse biological activities and pharmacology mechanism. Chin Herb Med. 2020;13(1):64–77.
Zhang SP, Wang RF, Zeng WY, et al. Resource investigation of traditional medicinal plant Panax japonicus (T. Nees) C. A. Mey and its varieties in China. J Ethnopharmacol. 2015;166:79–85.
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