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Melatonin inhibits Japanese encephalitis virus replication and neurotoxicity via calcineurin-autophagy pathways | BMC Neuroscience

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  • Unni SK, Růžek D, Chhatbar C, Mishra R, Johri MK, Singh SK. Japanese encephalitis virus: from genome to infectome. Microbes Infect. 2011;13(4):312–21.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sips GJ, Wilschut J, Smit JM. Neuroinvasive flavivirus Infections. Rev Med Virol. 2012;22(2):69–87.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Solomon T, Dung NM, Kneen R, Gainsborough M, Vaughn DW, Khanh VT. Japanese encephalitis. J Neurol Neurosurg Psychiatry. 2000;68(4):405–15.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu Q, Zhu N, Chen S, Zhao P, Ren H, Zhu S, Tang H, Zhu Y, Qi Z. E3 ubiquitin ligase Nedd4 promotes Japanese Encephalitis Virus replication by suppressing autophagy in human neuroblastoma cells. Sci Rep. 2017;7:45375.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Levine B, Kroemer G. Biological functions of Autophagy genes: a Disease Perspective. Cell. 2019;176(1–2):11–42.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gannagé M, Dormann D, Albrecht R, Dengjel J, Torossi T, Rämer PC, Lee M, Strowig T, Arrey F, Conenello G, et al. Matrix protein 2 of Influenza a virus blocks autophagosome fusion with lysosomes. Cell Host Microbe. 2009;6(4):367–80.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dreux M, Chisari FV. Viruses and the autophagy machinery. Cell Cycle (Georgetown Tex). 2010;9(7):1295–307.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jackson WT, Giddings TH Jr., Taylor MP, Mulinyawe S, Rabinovitch M, Kopito RR, Kirkegaard K. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol. 2005;3(5):e156.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Taguwa S, Kambara H, Fujita N, Noda T, Yoshimori T, Koike K, Moriishi K, Matsuura Y. Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating Hepatitis C virus. J Virol. 2011;85(24):13185–94.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, Wu L, Kominami E, Ueno T, Yamamoto A, et al. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol. 2009;186(2):255–68.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Joubert PE, Werneke SW, de la Calle C, Guivel-Benhassine F, Giodini A, Peduto L, Levine B, Schwartz O, Lenschow DJ, Albert ML. Chikungunya virus-induced autophagy delays caspase-dependent cell death. J Exp Med. 2012;209(5):1029–47.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Huang SH, Lien JC, Chen CJ, Liu YC, Wang CY, Ping CF, Lin YF, Huang AC, Lin CW. Antiviral activity of a Novel compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium overload. Int J Mol Sci 2016, 17(9).

  • Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci U S A. 2008;105(41):15803–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shibasaki F, Hallin U. Uchino HJTJob: Calcineurin as a multifunctional regulator. 2002, 131(1):1–15.

  • Mansuy IMJB. Calcineurin in memory and bidirectional plasticity. Commun Br. 2003;311(4):1195–208.

    CAS 

    Google Scholar
     

  • Hara MR, Snyder SH. Cell Signal Neuronal Death. 2007;47(1):117–41.

    CAS 

    Google Scholar
     

  • Fernandez AM, Fernandez S, Carrero P, Garcia-Garcia M, Torres-Aleman I. Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals. J Neurosci. 2007;27(33):8745–56.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Høyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, Bianchi K, Fehrenbacher N, Elling F, Rizzuto R, et al. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell. 2007;25(2):193–205.

    Article 
    PubMed 

    Google Scholar
     

  • Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M, Carling D. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metabol. 2005;2(1):21–33.

    Article 
    CAS 

    Google Scholar
     

  • Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabol. 2005;2(1):9–19.

    Article 
    CAS 

    Google Scholar
     

  • Overk CR, Rockenstein E, Florio J, Cheng Q, Masliah E. Differential calcium alterations in animal models of neurodegenerative Disease: reversal by FK506. Neuroscience. 2015;310:549–60.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stocki P, Sawicki M, Mays CE, Hong SJ, Chapman DC, Westaway D, Williams DB. Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein. Mol Biol Cell. 2016;27(5):757–67.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, et al. FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Autophagy. 2013;9(9):1386–94.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pardo R, Colin E, Régulier E, Aebischer P, Déglon N, Humbert S, Saudou F. Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421. J Neuroscience: Official J Soc Neurosci. 2006;26(5):1635–45.

    Article 
    CAS 

    Google Scholar
     

  • Emet M, Ozcan H, Ozel L, Yayla M, Halici Z, Hacimuftuoglu A. A review of Melatonin, its receptors and Drugs. Eurasian J Med. 2016;48(2):135–41.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kavakli A, Sahna E, Parlakpinar H, Yahsi S, Ogeturk M, Acet A. The effects of melatonin on focal cerebral ischemia-reperfusion model. Saudi Med J. 2004;25(11):1751–2.

    PubMed 

    Google Scholar
     

  • Alghamdi BS. The neuroprotective role of melatonin in neurological disorders. 2018, 96(7):1136–49.

  • Choi SI, Kim KS, Oh JY, Jin JY, Lee GH, Kim EK. Melatonin induces autophagy via an mTOR-dependent pathway and enhances clearance of mutant-TGFBIp. J Pineal Res. 2013;54(4):361–72.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen J, Wang L, Wu C, Hu Q, Gu C, Yan F, Li J, Yan W, Chen G. Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid Hemorrhage. J Pineal Res. 2014;56(1):12–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Boga JA, Caballero B, Potes Y, Perez-Martinez Z, Reiter RJ, Vega-Naredo I, Coto-Montes A. Therapeutic potential of melatonin related to its role as an autophagy regulator: a review. J Pineal Res. 2019;66(1):e12534.

    Article 
    PubMed 

    Google Scholar
     

  • Mehrzadi S, Karimi MY, Fatemi A, Reiter RJ, Hosseinzadeh A. SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin. Pharmacol Ther. 2021;224:107825.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Morchang A, Malakar S, Poonudom K, Noisakran S, Yenchitsomanus PT, Limjindaporn T. Melatonin inhibits dengue virus Infection via the sirtuin 1-Mediated Interferon Pathway. Viruses 2021, 13(4).

  • Ben-Nathan D, Maestroni GJ, Lustig S, Conti A. Protective effects of melatonin in mice infected with encephalitis viruses. Arch Virol. 1995;140(2):223–30.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Forster JI, Köglsberger S, Trefois C, Boyd O, Baumuratov AS, Buck L, Balling R, Antony PM. Characterization of differentiated SH-SY5Y as neuronal screening model reveals increased oxidative vulnerability. J BioMol Screen. 2016;21(5):496–509.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kovalevich J, Langford D. Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology. Methods in Molecular Biology (Clifton NJ). 2013;1078:9–21.

    Article 
    CAS 

    Google Scholar
     

  • Biedler JL, Roffler-Tarlov S, Schachner M, Freedman LS. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 1978;38(11 Pt 1):3751–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Lucas SM, Rothwell NJ, Gibson RM. The role of inflammation in CNS injury and Disease. Br J Pharmacol. 2006;147(Suppl 1):232–40.


    Google Scholar
     

  • Tweedie D, Sambamurti K, Greig NH. TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. Curr Alzheimer Res. 2007;4(4):378–85.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Brabers NA, Nottet HS. Role of the pro-inflammatory cytokines TNF-alpha and IL-1beta in HIV-associated Dementia. Eur J Clin Invest. 2006;36(7):447–58.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pineda JR, Pardo R, Zala D, Yu H, Humbert S. Saudou FJMb: Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington’s disease. 2009, 2(1):1–11.

  • Mukherjee A, Soto C. Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress. Curr Opin Cell Biol. 2011;23(2):223–30.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Frischbutter S, Gabriel C, Bendfeldt H, Radbruch A, Baumgrass R. Dephosphorylation of Bcl-10 by calcineurin is essential for canonical NF-κB activation in th cells. 2011, 41(8):2349–57.

  • Sharma M, Bhattacharyya S, Nain M, Kaur M, Sood V, Gupta V, Khasa R, Abdin MZ, Vrati S, Kalia M. Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes. Autophagy. 2014;10(9):1637–51.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sharma M, Bhattacharyya S, Sharma KB, Chauhan S, Asthana S, Abdin MZ, Vrati S, Kalia M. Japanese encephalitis virus activates autophagy through XBP1 and ATF6 ER stress sensors in neuronal cells. J Gen Virol. 2017;98(5):1027–39.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Moon JH, Park SY. Prion peptide-mediated calcium level alteration governs neuronal cell damage through AMPK-autophagy flux. Cell Communication and Signaling: CCS. 2020;18(1):109.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Choi JY, Kim JH, Patil AM, Kim SB, Uyangaa E, Hossain FMA, Eo SKJI. Exacerbation of Japanese encephalitis by CD11chi dendritic cell ablation is associated with an imbalance in regulatory Foxp3 + and IL-17 + CD4 + Th17 cells and in Ly-6Chi and Ly-6Clo monocytes. 2017, 17(3):192–200.

  • Moon JH, Eo SK, Lee JH, Park SY. Quercetin-induced autophagy flux enhances TRAIL-mediated Tumor cell death. Oncol Rep. 2015;34(1):375–81.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hong JM, Moon JH, Park SY. Human prion protein-mediated calcineurin activation induces neuron cell death via AMPK and autophagy pathway. Int J Biochem Cell Biol. 2020;119:105680.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Moon JH, Jeong JK, Hong JM, Seol JW, Park SY. Inhibition of Autophagy by Captopril attenuates prion peptide-mediated neuronal apoptosis via AMPK activation. Mol Neurobiol. 2019;56(6):4192–202.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jackson WT. Viruses and the autophagy pathway. Virology. 2015;479–480:450–6.

    Article 
    PubMed 

    Google Scholar
     

  • Paul P, Münz C. Autophagy and mammalian viruses: roles in Immune Response, viral replication, and Beyond. Adv Virus Res. 2016;95:149–95.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Orvedahl A, Alexander D, Tallóczy Z, Sun Q, Wei Y, Zhang W, Burns D, Leib DA, Levine B. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe. 2007;1(1):23–35.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sir D, Chen WL, Choi J, Wakita T, Yen TS, Ou JH. Induction of incomplete autophagic response by Hepatitis C virus via the unfolded protein response. Hepatology. 2008;48(4):1054–61.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016, 12(1):1-222.

  • Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol. 2005;5(6):472–84.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shibasaki F, Hallin U, Uchino H. Calcineurin as a multifunctional regulator. J BioChem. 2002;131(1):1–15.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu J, Farmer JD Jr., Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991;66(4):807–15.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • McCaffrey PG, Perrino BA, Soderling TR, Rao A. NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive Drugs. J Biol Chem. 1993;268(5):3747–52.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wiederrecht G, Lam E, Hung S, Martin M, Sigal N. The mechanism of action of FK-506 and cyclosporin A. Ann N Y Acad Sci. 1993;696:9–19.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Overk CR, Rockenstein E, Florio J, Cheng Q, Masliah EJN. Differential calcium alterations in animal models of neurodegenerative Disease: reversal by FK506. 2015, 310:549–60.

  • Karapetyan YE, Sferrazza GF, Zhou M, Ottenberg G, Spicer T, Chase P, Fallahi M, Hodder P, Weissmann C. Lasmézas CIJPotNAoS: unique drug screening approach for prion Diseases identifies tacrolimus and astemizole as antiprion agents. 2013, 110(17):7044–9.

  • Kim D, Hwang HY, Kim JY, Lee JY, Yoo JS, Marko-Varga G, Kwon HJ. FK506, an immunosuppressive drug, induces autophagy by binding to the V-ATPase Catalytic Subunit A in neuronal cells. J Proteome Res. 2017;16(1):55–64.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ding L, Nan WH, Zhu XB, Li XM, Zhou LY, Chen HJ, Yu L, Ullah Khan F, Zhong HB, Shi XJ. Rapamycin and FK506 derivative TH2849 could ameliorate neurodegenerative Diseases through autophagy with low immunosuppressive effect. CNS Neurosci Ther. 2019;25(4):452–64.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang Y, Lu J, Cheng W, Gao R, Yang L, Yang Z. FK506 protects heart function via increasing autophagy after Myocardial Infarction in mice. Biochem Biophys Res Commun. 2017;493(3):1296–303.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Reiter RJ, Maestroni GJM. Melatonin in relation to the antioxidative defense and immune systems: possible implications for cell and organ transplantation. J Mol Med. 1999;77(1):36–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Reiter RJ, Calvo JR, Karbownik M, Qi W, Tan DX. Melatonin and its relation to the immune system and inflammation. In: Annals of the New York Academy of Sciences vol. 917; 2000: 376–386.

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