Scientific Papers

Cross-sectional study: prevalence of oedema disease Escherichia coli (EDEC) in weaned piglets in Germany at pen and farm levels | Porcine Health Management


  • Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW, Zhang J. Diseases of swine. 11th ed. Hoboken: Wiley; 2019.

    Book 

    Google Scholar
     

  • Perrat A, Branchu P, Decors A, Turci S, Bayon-Auboyer M-H, Petit G, et al. Wild boars as reservoir of highly virulent clone of hybrid Shiga toxigenic and enterotoxigenic Escherichia coli responsible for edema disease. France Emerging Infect Dis. 2022;28(2):382–93.

    Article 
    CAS 

    Google Scholar
     

  • Imberechts H, de Greve H, Lintermans P. The pathogenesis of edema disease in pigs A review. Vet Microbiol. 1992;31:221–33.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Casanova NA, Redondo LM, Dailoff GC, Arenas D, Fernández Miyakawa ME. Overview of the role of Shiga toxins in porcine edema disease pathogenesis. Toxicon. 2018;148:149–54.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nagy B, Whipp SC, Imberechts H, Bertschinger HU, Dean-Nystrom EA, Casey TA, et al. Biological relationship between F18ab and F18ac fimbriae of enterotoxigenic and verotoxigenic Escherichia coli from weaned pigs with oedema disease or diarrhoea. Microb Pathog. 1997;22(1):1–11.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Coddens A, Diswall M, Angström J, Breimer ME, Goddeeris B, Cox E, et al. Recognition of blood group ABH type 1 determinants by the FedF adhesin of F18-fimbriated Escherichia coli. J Biol Chem. 2009;284(15):9713–26.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Moxley RA. Edema disease. Vet Clin North Am Food Anim Pract. 2000;16(1):175–85.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Müthing J, Meisen I, Zhang W, Bielaszewska M, Mormann M, Bauerfeind R, et al. Promiscuous Shiga toxin 2e and its intimate relationship to Forssman. Glycobiology. 2012;22(6):849–62.

    Article 
    PubMed 

    Google Scholar
     

  • Cornick NA, Matise I, Samuel JE, Bosworth BT, Moon HW. Shiga toxin-producing Escherichia coli infection: temporal and quantitative relationships among colonization, toxin production, and systemic disease. J Infect Dis. 2000;181:242–51.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gannon VP, Gyles CL, Friendship RW. Characteristics of verotoxigenic Escherichia coli from pigs. Can J Vet Res. 1988;52(3):331–7.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gyles CL. Shiga toxin-producing Escherichia coli: an overview. J Anim Sci. 2007;85(13 Suppl):E45-62.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nagy B, Wilson RA, Whittam TS. Genetic diversity among Escherichia coli isolates carrying f18 genes from pigs with porcine postweaning diarrhea and edema disease. J Clin Microbiol. 1999;37(5):1642–5.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Niewerth U, Frey A, Voss T, Le Bouguénec C, Baljer G, Franke S, et al. The AIDA autotransporter system is associated with F18 and stx2e in Escherichia coli isolates from pigs diagnosed with edema disease and postweaning diarrhea. Clin Diagn Lab Immunol. 2001;8(1):143–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Luppi A. Swine enteric colibacillosis: diagnosis, therapy and antimicrobial resistance. Porcine Health Manag. 2017;3:16.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Barth S, Tscholshiew A, Menge C, Weiss R, Baljer G, Bauerfeind R. Virulence and fitness gene patterns of Shiga toxin-encoding Escherichia coli isolated from pigs with edema disease or diarrhea in Germany. Berl Munch Tierarztl Wochenschr. 2007;120(7–8):307–16.

    CAS 
    PubMed 

    Google Scholar
     

  • Meisen I, Rosenbrück R, Galla H-J, Hüwel S, Kouzel IU, Mormann M, et al. Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood-brain barrier. Glycobiology. 2013;23(6):745–59.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Matise I, Sirinarumitr T, Bosworth BT, Moon HW. Vascular ultrastructure and DNA fragmentation in swine infected with Shiga toxin-producing Escherichia coli. Vet Pathol. 2000;37:318–27.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rhouma M, Beaudry F, Thériault W, Letellier A. Colistin in pig production: chemistry, mechanism of antibacterial action, microbial resistance emergence, and one health perspectives. Front Microbiol. 2016;7:1789.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kausche FM, Dean EA, Arp LH, Samuel JE, Moon HW. An experimental model for subclinical edema disease (Escherichia coli enterotoxemia) manifest as vascular necrosis in pigs. Am J Vet Res. 1992;53(3):281–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Leneveu P, Collet J, Sévin J, Durand A, Solignac T, Jardin A, Creac’h P, Amenna N, Turci S, Moalic P, Schüler V. Investigation of subacute edema disease in France. Impact on swine performance. In: Abstract book, 11th European symposium of porcine health management, Utrecht/Netherlands; 2019. p. 201.

  • Barth SA, Bauerfeind R, Berens C, Menge C. Shiga toxin-producing E. coli in animals: detection, characterization, and virulence assessment. Methods Mol Biol. 2021;2291:19–86.

    Article 
    PubMed 

    Google Scholar
     

  • Hermanns S, Kerner K, Schueler V, Berger PI, Doherr MG, Ewers C et al. Detection of Stx2e-encoding E. coli in weaning piglets: comparison of methods for sampling and sample processing. In: ESPHM proceedings, April 14th–16th, 2021; 2021. p. 341.

  • Sarrazin E, Fritzsche C, Bertschinger HU. Hauptvirulenzfaktoren bei Escherichia coli-Isolaten von über zwei Wochen alten Schweinen mit Ödemkrankheit und/oder Colidiarrhöe. Schweiz Arch Tierheilkd. 2000;142(11):625–30.

    CAS 
    PubMed 

    Google Scholar
     

  • Frydendahl K. Prevalence of serogroups and virulence genes in Escherichia coli associated with postweaning diarrhoea and edema disease in pigs and a comparison of diagnostic approaches. Vet Microbiol. 2002;85(2):169–82.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lauer WF, Martinez FL, Patel A. Validation of RAPID’ E. coli 2 for enumeration and differentiation of Escherichia coli and other coliform bacteria in selected foods. J AOAC Int. 2007;90(5):1284–315.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Blanco M, Blanco JE, Gonzalez EA, Mora A, Jansen W, Gomes TA, et al. Genes coding for enterotoxins and verotoxins in porcine Escherichia coli strains belonging to different O:K: H serotypes: relationship with toxic phenotypes. J Clin Microbiol. 1997;35(11):2958–63.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Casey TA, Bosworth BT. Design and evaluation of a multiplex polymerase chain reaction assay for the simultaneous identification of genes for nine different virulence factors associated with Escherichia coli that cause diarrhea and edema disease in swine. J Vet Diagn Invest. 2009;21(1):25–30.

    Article 
    PubMed 

    Google Scholar
     

  • L. Valls, A. Sánchez, J. Maldonado. Improving edema disease diagnosis in pigs by detecting the Vt2e toxin gen in oral fluid by qPCR. In: ESPHM proceedings 2018, 10th European symposium of porcine health management, Barcelona/Spain; 2018. p. 221.

  • Prickett JR, Kim W, Simer R, Yoon K-J, Zimmerman J. Oral-fluid samples for surveillance of commercial growing pigs for porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 infections. J Swine Health Prod. 2008;16(2):86–91.


    Google Scholar
     

  • Prickett JR, Zimmerman JJ. The development of oral fluid-based diagnostics and applications in veterinary medicine. Anim Health Res Rev. 2010;11(2):207–16.

    Article 
    PubMed 

    Google Scholar
     

  • Atkinson BM, Bearson BL, Loving CL, Zimmerman JJ, Kich JD, Bearson SMD. Detection of Salmonella-specific antibody in swine oral fluids. Porcine Health Manag. 2019;5:29.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • European Medicines Agency. http://ema.europa.eu. Accessed 24 July 2023

  • Fricke R, Bastert O, Gotter V, Brons N, Kamp J, Selbitz H-J. Implementation of a vaccine against Shigatoxin 2e in a piglet producing farm with problems of oedema disease: case study. Porcine Health Manag. 2015;1:6.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Perozo E, Mallorquí J, Puig A, Sabaté D, Ferrer-Soler L, March R. A multicenter, randomized field trial on the efficacy and safety of VEPURED®, A new vaccine against edema disease in pigs. Anim Vet Sci. 2018;6(6):95–101.


    Google Scholar
     

  • Kramer T. Edema disease of swine: I. Study of hemolytic Escherichia coli strains isolated from cases of edema disease of swine in Western Canada. Can J Comp Med Vet Sci. 1960;24(10):289–94.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Beutin L, Geier D, Steinrück H, Zimmermann S, Scheutz F. Prevalence and some properties of verotoxin (Shiga-like toxin)-producing Escherichia coli in seven different species of healthy domestic animals. J Clin Microbiol. 1993;31:2483–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Garabal JI, González EA, Vázquez F, Blanco J, Blanco M, Blanco JE. Serogroups of Escherichia coli isolated from piglets in Spain. Vet Microbiol. 1996;48(1–2):113–23.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kwon D, Choi C, Jung T, Chung HK, Kim JP, Bae SS, et al. Genotypic prevalence of the fimbrial adhesins (F4, F5, F6, F41 and F18) and toxins (LT, STa, STb and STx2e) in Escherichia coli isolated from postweaning pigs with diarrhoea or oedema disease in Korea. Vet Rec. 2002;150(2):35–7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ha S-K, Choi C, Chae C. Prevalence of a gene encoding adhesin involved in diffuse adherence among Escherichia coli isolates in pigs with postweaning diarrhea or edema disease. J Vet Diagn Invest. 2003;15(4):378–81.

    Article 
    PubMed 

    Google Scholar
     

  • Cheng D, Sun H, Xu J, Gao S. Prevalence of fimbial colonization factors F18ab and F18ac in Escherichia coli isolates from weaned piglets with edema and/or diarrhea in China. Vet Microbiol. 2005;110(1–2):35–9.

    Article 
    PubMed 

    Google Scholar
     

  • Bessone FA, Bessone G, Marini S, Conde MB, Alustiza FE, Zielinski G. Presence and characterization of Escherichia coli virulence genes isolated from diseased pigs in the central region of Argentina. Vet World. 2017;10(8):939–45.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cha W, Fratamico PM, Ruth LE, Bowman AS, Nolting JM, Manning SD, et al. Prevalence and characteristics of Shiga toxin-producing Escherichia coli in finishing pigs: Implications on public health. Int J Food Microbiol. 2018;264:8–15.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tseng M, Fratamico PM, Bagi L, Manzinger D, Funk JA. Shiga toxin-producing E. coli (STEC) in swine: prevalence over the finishing period and characteristics of the STEC isolates. Epidemiol Infect. 2015;143(3):505–14.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vallejo Direktor GA. Seroepidemiologische Untersuchungen zur Verbreitung Shigatoxin (Stx)2e-bildender Escherichia coli in hessischen Schweinezuchtbeständen. Gießen: Justus-Liebig-Universität Gießen; 2010.


    Google Scholar
     

  • Henton MM, Engelbrecht MM. Escherichia coli serotypes in pigs in South Africa. Onderstepoort J Vet Res. 1997;64(3):175–87.

    CAS 
    PubMed 

    Google Scholar
     

  • Oanh TKN, Nguyen VK, Do TN, Goddeeris BM, de Greve H. Escherichia coli strains causing edema disease in northern Vietnam share an identical verotoxin 2e. Trop Anim Health Prod. 2010;42(8):1797–804.

    Article 
    PubMed 

    Google Scholar
     

  • Luppi A, Gibellini M, Gin T, Vangroenweghe F, Vandenbroucke V, Bauerfeind R, et al. Prevalence of virulence factors in enterotoxigenic Escherichia coli isolated from pigs with post-weaning diarrhoea in Europe. Porcine Health Manag. 2016;2:20.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hewitt K, Brown J, Skoland K, Nickel M, Ruston C, Breuer M et al., editors. Shiga toxin-producing Escherichia coli (STEC) detection and characterization among US swine herds: Poster 05; 2021.

  • Fratamico PM, Bagi LK, Bush EJ, Solow BT. Prevalence and characterization of shiga toxin-producing Escherichia coli in swine feces recovered in the National Animal Health Monitoring System’s Swine 2000 study. Appl Environ Microbiol. 2004;70(12):7173–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zweifel C, Schumacher S, Beutin L, Blanco J, Stephan R. Virulence profiles of Shiga toxin 2e-producing Escherichia coli isolated from healthy pig at slaughter. Vet Microbiol. 2006;117(2–4):328–32.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Baldo V, Salogni C, Giovannini S, D’Incau M, Boniotti MB, Birbes L, et al. Pathogenicity of Shiga toxin type 2e Escherichia coli in pig colibacillosis. Front Vet Sci. 2020;7:545818.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Meng Q, Bai X, Zhao A, Lan R, Du H, Wang T, et al. Characterization of Shiga toxin-producing Escherichia coli isolated from healthy pigs in China. BMC Microbiol. 2014;14(5):1471–2180.


    Google Scholar
     

  • Mainil JG, Jacquemin E, Pohl P, Kaeckenbeeck A, Benz I. DNA sequences coding for the F18 fimbriae and AIDA adhesin are localised on the same plasmid in Escherichia coli isolates from piglets. Vet Microbiol. 2002;86(4):303–11.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Plut J, Jamnikar-Ciglenecki U, Stukelj M. Molecular detection of porcine reproductive and respiratory syndrome virus, porcine circovirus 2 and hepatitis E virus in oral fluid compared to their detection in faeces and serum. BMC Vet Res. 2020;16(1):164.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Soave O, Brand CD. Coprophagy in animals: a review. Cornell Vet. 1991;81:357–64.

    CAS 
    PubMed 

    Google Scholar
     

  • Fredriksson-Ahomaa M, Gerhardt M, Stolle A. High bacterial contamination of pig tonsils at slaughter. Meat Sci. 2009;83(2):334–6.

    Article 
    PubMed 

    Google Scholar
     

  • Jakobsen AM, Bahl MI, Buschhardt T, Hansen TB, Al-Soud WA, Brejnrod AD, et al. Bacterial community analysis for investigating bacterial transfer from tonsils to the pig carcass. Int J Food Microbiol. 2019;295:8–18.

    Article 
    PubMed 

    Google Scholar
     

  • Dawson L, Edwards SA. The effects of flavored rope additives on commercial pen-based oral fluid yield in pigs. J Vet Behavior. 2015;10:267–71.

    Article 

    Google Scholar
     

  • Henao-Diaz A, Giménez-Lirola L, Baum DH, Zimmerman J. Guidelines for oral fluid-based surveillance of viral pathogens in swine. Porcine Health Manag. 2020;6:28.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Woodward MJ, Kearsley R, Wray C, Roeder PL. DNA probes for the detection of toxin genes in Escherichia coli isolated from diarrhoeal disease in cattle and pigs. Vet Microbiol. 1990;22(2–3):277–90.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jones GF, Ward GE, Murtaugh MP, Lin G, Gebhart CJ. Enhanced detection of intracellular organism of swine proliferative enteritis, ileal symbiont intracellularis, in feces by polymerase chain reaction. J Clin Microbiol. 1993;31(10):2611–5.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dünser M, Schweighardt H, Krassnig G. Nachweis von Lawsonia intracellularis, des Erregers der Proliferativen Enteropathien des Schweines (Adenomatose-Komplex) mittels Polymerase-Kettenreaktion in Oberösterreich. Wien Tierärztl Mschr. 1997;84:307–13.


    Google Scholar
     

  • Scheutz F, Teel LD, Beutin L, Piérard D, Buvens G, Karch H, et al. Multicenter evaluation of a sequence-based protocol for subtyping Shiga toxins and standardizing Stx nomenclature. J Clin Microbiol. 2012;50(9):2951–63.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     



  • Source link