Scientific Papers

Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy | Military Medical Research


  • Topjian AA, de Caen A, Wainwright MS, Abella BS, Abend NS, Atkins DL, et al. Pediatric post-cardiac arrest care: a scientific statement from the American Heart Association. Circulation. 2019;140(6):e194–233.

    Article 
    PubMed 

    Google Scholar
     

  • Cheung CMG, Fawzi A, Teo KY, Fukuyama H, Sen S, Tsai WS, et al. Diabetic macular ischaemia—a new therapeutic target? Prog Retin Eye Res. 2022;89:101033.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lang M, Som A, Mendoza DP, Flores EJ, Reid N, Carey D, et al. Hypoxaemia related to COVID-19: vascular and perfusion abnormalities on dual-energy CT. Lancet Infect Dis. 2020;20(12):1365–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bepouka B, Odio O, Mayasi N, Longokolo M, Mangala D, Mandina M, et al. Prevalence and outcomes of COVID-19 patients with happy hypoxia: a systematic review. Infect Drug Resist. 2022;15:5619–28.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chvojka J, Martinkova V, Benes J, Valesova L, Danihel V, Nalos L, et al. Mechanical circulatory support in refractory vasodilatory septic shock: a randomized controlled porcine study. Shock. 2020;53(1):124–31.

    Article 
    PubMed 

    Google Scholar
     

  • Yamamoto R, Yoshizawa J. Oxygen administration in patients recovering from cardiac arrest: a narrative review. J Intensive Care. 2020;8:60.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Meng X, Tan J, Li M, Song S, Miao Y, Zhang Q. Sirt1: role under the condition of ischemia/hypoxia. Cell Mol Neurobiol. 2017;37(1):17–28.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xiao MJ, Zou XF, Li B, Li BL, Wu SJ, Zhang B. Simulated aeromedical evacuation exacerbates burn induced lung injury: targeting mitochondrial DNA for reversal. Mil Med Res. 2021;8(1):30.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Duan C, Ma R, Zeng X, Chen B, Hou D, Liu R, et al. SARS-CoV-2 achieves immune escape by destroying mitochondrial quality: comprehensive analysis of the cellular landscapes of lung and blood specimens from patients with COVID-19. Front Immunol. 2022;13:946731.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ham PB 3rd, Raju R. Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol. 2017;157:92–116.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Duan C, Kuang L, Xiang X, Zhang J, Zhu Y, Wu Y, et al. Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways. Cell Death Dis. 2020;11(4):251.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jin JY, Wei XX, Zhi XL, Wang XH, Meng D. Drp1-dependent mitochondrial fission in cardiovascular disease. Acta Pharmacol Sin. 2021;42(5):655–64.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Duan C, Kuang L, Hong C, Xiang X, Liu J, Li Q, et al. Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2. Cell Death Dis. 2021;12(11):1050.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Duan C, Kuang L, Xiang X, Zhang J, Zhu Y, Wu Y, et al. Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock. Aging (Albany NY). 2020;12(2):1397–416.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Duan C, Wang L, Zhang J, Xiang X, Wu Y, Zhang Z, et al. Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity. Redox Biol. 2020;37:101706.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zeng X, Zhang YD, Ma RY, Chen YJ, Xiang XM, Hou DY, et al. Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis. Mil Med Res. 2022;9(1):25.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jhun BS, O-Uchi J, Adaniya SM, Cypress MW, Yoon Y. Adrenergic regulation of Drp1-driven mitochondrial fission in cardiac physio-pathology. Antioxidants (Basel). 2018;7(12):195.

    Article 
    PubMed 

    Google Scholar
     

  • Fröhlich C, Grabiger S, Schwefel D, Faelber K, Rosenbaum E, Mears J, et al. Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein. EMBO J. 2013;32(9):1280–92.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wenger J, Klinglmayr E, Fröhlich C, Eibl C, Gimeno A, Hessenberger M, et al. Functional mapping of human dynamin-1-like GTPase domain based on X-ray structure analyses. PLoS ONE. 2013;8(8):e71835.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vetter IR, Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science. 2001;294(5545):1299–304.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Praefcke GJ, McMahon HT. The dynamin superfamily: universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol. 2004;5(2):133–47.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chappie JS, Acharya S, Leonard M, Schmid SL, Dyda F. G domain dimerization controls dynamin’s assembly-stimulated GTPase activity. Nature. 2010;465(7297):435–40.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, et al. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell. 2011;147(1):209–22.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu B, Ma J, Li J, Wang D, Wang Z, Wang S. Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics. Nat Commun. 2020;11(1):2549.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Faelber K, Posor Y, Gao S, Held M, Roske Y, Schulze D, et al. Crystal structure of nucleotide-free dynamin. Nature. 2011;477(7366):556–60.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ford MGJ, Jenni S, Nunnari J. The crystal structure of dynamin. Nature. 2011;477(7366):561–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gao S, von der Malsburg A, Paeschke S, Behlke J, Haller O, Kochs G, et al. Structural basis of oligomerization in the Stalk region of dynamin-like MxA. Nature. 2010;465(7297):502–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chappie JS, Acharya S, Liu YW, Leonard M, Pucadyil TJ, Schmid SL. An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol Biol Cell. 2009;20(15):3561–71.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Strack S, Cribbs JT. Allosteric modulation of Drp1 mechanoenzyme assembly and mitochondrial fission by the variable domain. J Biol Chem. 2012;287(14):10990–1001.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Reubold TF, Faelber K, Plattner N, Posor Y, Ketel K, Curth U, et al. Crystal structure of the dynamin tetramer. Nature. 2015;525(7569):404–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Srinivasan S, Mattila JP, Schmid SL. Intrapolypeptide interactions between the GTPase effector domain (GED) and the GTPase domain form the bundle signaling element in dynamin dimers. Biochemistry. 2014;53(36):5724–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Feng ST, Wang ZZ, Yuan YH, Wang XL, Sun HM, Chen NH, et al. Dynamin-related protein 1: a protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson’s disease. Pharmacol Res. 2020;151:104553.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • MacDonald PJ, Stepanyants N, Mehrotra N, Mears JA, Qi X, Sesaki H, et al. A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Mol Biol Cell. 2014;25(12):1905–15.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zeng Z, Li H, You M, Rong R, Xia X. Dephosphorylation of ERK1/2 and DRP1 S585 regulates mitochondrial dynamics in glutamate toxicity of retinal neurons in vitro. Exp Eye Res. 2022;225:109271.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen S, Liu S, Wang J, Wu Q, Wang A, Guan H, et al. TBK1-mediated DRP1 targeting confers nucleic acid sensing to reprogram mitochondrial dynamics and physiology. Mol Cell. 2020;80(5):810-27.e7.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Valera-Alberni M, Joffraud M, Miro-Blanch J, Capellades J, Junza A, Dayon L, et al. Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation. Cell Rep. 2021;36(8):109565.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Al-Lamki RS, Lu W, Manalo P, Wang J, Warren AY, Tolkovsky AM, et al. Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis. Cell Death Dis. 2016;7(6):e2287.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K. Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem. 2007;282(15):11521–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Cho B, Cho HM, Kim HJ, Jeong J, Park SK, Hwang EM, et al. CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation. Exp Mol Med. 2014;46:e105.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim DI, Lee KH, Gabr AA, Choi GE, Kim JS, Ko SH, et al. Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis. Biochim Biophys Acta. 2016;1863(11):2820–34.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ma R, Ma L, Weng W, Wang Y, Liu H, Guo R, et al. DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation. Sci Adv. 2020;6(13):eaaz0361.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • She L, Tu H, Zhang YZ, Tang LJ, Li NS, Ma QL, et al. Inhibition of phosphoglycerate mutase 5 reduces necroptosis in rat hearts following ischemia/reperfusion through suppression of dynamin-related protein 1. Cardiovasc Drugs Ther. 2019;33(1):13–23.

    Article 
    PubMed 

    Google Scholar
     

  • Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, et al. Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res. 2012;110(11):1484–97.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang C, Huang J, An W. Hepatic stimulator substance resists hepatic ischemia/reperfusion injury by regulating Drp1 translocation and activation. Hepatology. 2017;66(6):1989–2001.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zheng QY, Li Y, Liang SJ, Chen XM, Tang M, Rao ZS, et al. LIGHT deficiency attenuates acute kidney disease development in an in vivo experimental renal ischemia and reperfusion injury model. Cell Death Discov. 2022;8(1):399.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gao Q, Tian R, Han H, Slone J, Wang C, Ke X, et al. PINK1-mediated Drp1S616 phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission. Signal Transduct Target Ther. 2022;7(1):103.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cao L, Mu W. Necrostatin-1 and necroptosis inhibition: pathophysiology and therapeutic implications. Pharmacol Res. 2021;163:105297.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Archer SL, Dasgupta A, Chen KH, Wu D, Baid K, Mamatis JE, et al. SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia. Redox Biol. 2022;58:102508.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schmitt K, Grimm A, Dallmann R, Oettinghaus B, Restelli LM, Witzig M, et al. Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics. Cell Metab. 2018;27(3):657-66.e5.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xie LL, Shi F, Tan Z, Li Y, Bode AM, Cao Y. Mitochondrial network structure homeostasis and cell death. Cancer Sci. 2018;109(12):3686–94.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhan L, Lu Z, Zhu X, Xu W, Li L, Li X, et al. Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats. FASEB J. 2019;33(1):1313–29.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sharp WW, Fang YH, Han M, Zhang HJ, Hong Z, Banathy A, et al. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J. 2014;28(1):316–26.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, et al. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med. 2011;17(1):71–8.

    Article 
    PubMed 

    Google Scholar
     

  • Yu X, Jia L, Yu W, Du H. Dephosphorylation by calcineurin regulates translocation of dynamin-related protein 1 to mitochondria in hepatic ischemia reperfusion induced hippocampus injury in young mice. Brain Res. 2019;1711:68–76.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, et al. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell. 2011;44(4):532–44.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Prudent J, Zunino R, Sugiura A, Mattie S, Shore GC, McBride HM. MAPL SUMOylation of Drp1 stabilizes an ER/mitochondrial platform required for cell death. Mol Cell. 2015;59(6):941–55.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Abe JI, Sandhu UG, Hoang NM, Thangam M, Quintana-Quezada RA, Fujiwara K, et al. Coordination of cellular localization-dependent effects of sumoylation in regulating cardiovascular and neurological diseases. Adv Exp Med Biol. 2017;963:337–58.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yamada S, Sato A, Ishihara N, Akiyama H, Sakakibara SI. Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development. iScience. 2021;24(12):103484.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Adaniya SM, O-Uchi J, Cypress MW, Kusakari Y, Jhun BS. Posttranslational modifications of mitochondrial fission and fusion proteins in cardiac physiology and pathophysiology. Am J Physiol Cell Physiol. 2019;316(5):C583–604.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guo C, Hildick KL, Jiang J, Zhao A, Guo W, Henley JM, et al. SENP3 promotes an Mff-primed Bcl-xL-Drp1 interaction involved in cell death following ischemia. Front Cell Dev Biol. 2021;9:752260.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Huang J, Xie P, Dong Y, An W. Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury. Cell Death Differ. 2021;28(4):1174–92.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shi L, Liu J, Peng Y, Zhang J, Dai X, Zhang S, et al. Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Mol Oncol. 2020;14(12):3169–83.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sulkshane P, Ram J, Thakur A, Reis N, Kleifeld O, Glickman MH. Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Redox Biol. 2021;45:102047.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Das R, Kamal IM, Das S, Chakrabarti S, Chakrabarti O. MITOL-mediated DRP1 ubiquitylation and degradation promotes mitochondrial hyperfusion in a CMT2A-linked MFN2 mutant. J Cell Sci. 2022;135(2):jcs257808.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, et al. Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Mol Biol Cell. 2011;22(8):1207–16.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim YM, Youn SW, Sudhahar V, Das A, Chandhri R, Cuervo Grajal H, et al. Redox regulation of mitochondrial fission protein Drp1 by protein disulfide isomerase limits endothelial senescence. Cell Rep. 2018;23(12):3565–78.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rizza S, Filomeni G. Denitrosylate and live longer: how ADH5/GSNOR links mitophagy to aging. Autophagy. 2018;14(7):1285–7.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bossy B, Petrilli A, Klinglmayr E, Chen J, Lütz-Meindl U, Knott AB, et al. S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer’s disease. J Alzheimers Dis. 2010;20(Suppl 2):S513–26.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang Y, He Y, Wu M, Chen H, Zhang L, Yang D, et al. Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation. Free Radic Biol Med. 2020;160:526–39.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Akhtar MW, Sanz-Blasco S, Dolatabadi N, Parker J, Chon K, Lee MS, et al. Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nat Commun. 2016;7:10242.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang L, Wang Z, You W, Yu Z, Li X, Shen H, et al. Enhancing S-nitrosoglutathione reductase decreases S-nitrosylation of Drp1 and reduces neuronal apoptosis in experimental subarachnoid hemorrhage both in vivo and in vitro. Brain Res Bull. 2022;183:184–200.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pang L, Jiang X, Lian X, Chen J, Song EF, Jin LG, et al. Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences. Mil Med Res. 2022;9(1):33.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Oleinik N, Kim J, Roth BM, Selvam SP, Gooz M, Johnson RH, et al. Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. Sci Adv. 2019;5(9):eaax1978.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou J, Xu L, Duan X, Liu W, Zhao X, Wang X, et al. Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis. Sci Adv. 2019;5(9):eaax0365.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jheng HF, Huang SH, Kuo HM, Hughes MW, Tsai YS. Molecular insight and pharmacological approaches targeting mitochondrial dynamics in skeletal muscle during obesity. Ann N Y Acad Sci. 2015;1350:82–94.

    Article 
    PubMed 

    Google Scholar
     

  • Gawlowski T, Suarez J, Scott B, Torres-Gonzalez M, Wang H, Schwappacher R, et al. Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-β-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes. J Biol Chem. 2012;287(35):30024–34.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Park SJ, Bae JE, Jo DS, Kim JB, Park NY, Fang J, et al. Increased O-GlcNAcylation of Drp1 by amyloid-β promotes mitochondrial fission and dysfunction in neuronal cells. Mol Brain. 2021;14(1):6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, et al. Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep. 2021;11(1):22106.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hu Q, Zhang H, Gutiérrez Cortés N, Wu D, Wang P, Zhang J, et al. Increased Drp1 acetylation by lipid overload induces cardiomyocyte death and heart dysfunction. Circ Res. 2020;126(4):456–70.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Osellame LD, Singh AP, Stroud DA, Palmer CS, Stojanovski D, Ramachandran R, et al. Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission. J Cell Sci. 2016;129(11):2170–81.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kleele T, Rey T, Winter J, Zaganelli S, Mahecic D, Perreten Lambert H, et al. Distinct fission signatures predict mitochondrial degradation or biogenesis. Nature. 2021;593(7859):435–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Itoyama A, Michiyuki S, Honsho M, Yamamoto T, Moser A, Yoshida Y, et al. Mff functions with Pex11pβ and DLP1 in peroxisomal fission. Biol Open. 2013;2(10):998–1006.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, et al. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol. 2010;191(6):1141–58.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stepanyants N, MacDonald PJ, Francy CA, Mears JA, Qi X, Ramachandran R. Cardiolipin’s propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission. Mol Biol Cell. 2015;26(17):3104–16.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Palmer CS, Elgass KD, Parton RG, Osellame LD, Stojanovski D, Ryan MT. Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J Biol Chem. 2013;288(38):27584–93.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kalia R, Wang RYR, Yusuf A, Thomas PV, Agard DA, Shaw JM, et al. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. 2018;558(7710):401–5.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Atkins K, Dasgupta A, Chen KH, Mewburn J, Archer SL. The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease. Clin Sci (Lond). 2016;130(21):1861–74.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ma J, Zhai Y, Chen M, Zhang K, Chen Q, Pang X, et al. New interfaces on MiD51 for Drp1 recruitment and regulation. PLoS ONE. 2019;14(1):e0211459.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao J, Liu T, Jin S, Wang X, Qu M, Uhlén P, et al. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J. 2011;30(14):2762–78.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Losón OC, Song Z, Chen H, Chan DC. Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell. 2013;24(5):659–67.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen KH, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, et al. Epigenetic dysregulation of the dynamin-related protein 1 binding partners MiD49 and MiD51 increases mitotic mitochondrial fission and promotes pulmonary arterial hypertension: mechanistic and therapeutic implications. Circulation. 2018;138(3):287–304.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu R, Jin SB, Ankarcrona M, Lendahl U, Nistér M, Zhao J. The molecular assembly state of Drp1 controls its association with the mitochondrial recruitment receptors Mff and MIEF1/2. Front Cell Dev Biol. 2021;9:706687.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cherok E, Xu S, Li S, Das S, Meltzer WA, Zalzman M, et al. Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics. Mol Biol Cell. 2017;28(3):396–410.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wong YC, Kim S, Cisneros J, Molakal CG, Song P, Lubbe SJ, et al. Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics. J Cell Biol. 2022;221(10):e202206140.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu Y, Peng XD, Qian XJ, Zhang KM, Huang X, Chen YH, et al. Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis. Signal Transduct Target Ther. 2021;6(1):401.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang S, Zhu H, Li R, Mui D, Toan S, Chang X, et al. DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury. Sci Signal. 2022;15(725):eabh1121.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zou R, Shi W, Qiu J, Zhou N, Du N, Zhou H, et al. Empagliflozin attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial homeostasis. Cardiovasc Diabetol. 2022;21(1):106.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu R, Jin SB, Lendahl U, Nister M, Zhao J. Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery. EMBO J. 2019;38(8):e99748.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, et al. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci USA. 2013;110(15):E1342–51.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bardai FH, Ordonez DG, Bailey RM, Hamm M, Lewis J, Feany MB. Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics. PLoS Biol. 2018;16(12):e2006265.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Su YC, Qi X. Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation. Hum Mol Genet. 2013;22(22):4545–61.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang X, Yan MH, Fujioka H, Liu J, Wilson-Delfosse A, Chen SG, et al. LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Hum Mol Genet. 2012;21(9):1931–44.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Weindel CG, Bell SL, Vail KJ, West KO, Patrick KL, Watson RO. LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis. Elife. 2020;9:e51071.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tilokani L, Nagashima S, Paupe V, Prudent J. Mitochondrial dynamics: overview of molecular mechanisms. Essays Biochem. 2018;62(3):341–60.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Manor U, Bartholomew S, Golani G, Christenson E, Kozlov M, Higgs H, et al. A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division. Elife. 2015;4:e08828.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Friedman JR, Lackner LL, West M, DiBenedetto JR, Nunnari J, Voeltz GK. ER tubules mark sites of mitochondrial division. Science. 2011;334(6054):358–62.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Smirnova E, Griparic L, Shurland DL, van der Bliek AM. Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell. 2001;12(8):2245–56.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ban-Ishihara R, Ishihara T, Sasaki N, Mihara K, Ishihara N. Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c. Proc Natl Acad Sci USA. 2013;110(29):11863–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ingerman E, Perkins EM, Marino M, Mears JA, McCaffery JM, Hinshaw JE, et al. Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol. 2005;170(7):1021–7.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mears JA, Lackner LL, Fang S, Ingerman E, Nunnari J, Hinshaw JE. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat Struct Mol Biol. 2011;18(1):20–6.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lee JE, Westrate LM, Wu H, Page C, Voeltz GK. Multiple dynamin family members collaborate to drive mitochondrial division. Nature. 2016;540(7631):139–43.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Adachi Y, Kato T, Yamada T, Murata D, Arai K, Stahelin RV, et al. Drp1 tubulates the ER in a GTPase-independent manner. Mol Cell. 2020;80(4):621-32.e6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fonseca TB, Sánchez-Guerrero Á, Milosevic I, Raimundo N. Mitochondrial fission requires DRP1 but not dynamins. Nature. 2019;570(7761):E34–42.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chakrabarti R, Higgs HN. Revolutionary view of two ways to split a mitochondrion. Nature. 2021;593(7859):346–7.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cho HM, Ryu JR, Jo Y, Seo TW, Choi YN, Kim JH, et al. Drp1-Zip1 interaction regulates mitochondrial quality surveillance system. Mol Cell. 2019;73(2):364-76.e8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Cho HM, Sun W. The coordinated regulation of mitochondrial structure and function by Drp1 for mitochondrial quality surveillance. BMB Rep. 2019;52(2):109–10.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sun S, Yu W, Xu H, Li C, Zou R, Wu NN, et al. TBC1D15-Drp1 interaction-mediated mitochondrial homeostasis confers cardioprotection against myocardial ischemia/reperfusion injury. Metabolism. 2022;134:155239.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Carter RJ, Milani M, Beckett AJ, Liu S, Prior IA, Cohen GM, et al. Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis. Cell Death Dis. 2022;13(5):436.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao Y, Zhang M, Zhang W, Zhou Y, Chen L, Liu Q, et al. Isotropic super-resolution light-sheet microscopy of dynamic intracellular structures at subsecond timescales. Nat Methods. 2022;19(3):359–69.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hatch AL, Gurel PS, Higgs HN. Novel roles for actin in mitochondrial fission. J Cell Sci. 2014;127(Pt 21):4549–60.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hatch AL, Ji WK, Merrill RA, Strack S, Higgs HN. Actin filaments as dynamic reservoirs for Drp1 recruitment. Mol Biol Cell. 2016;27(20):3109–21.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, et al. USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites. J Cell Biol. 2021;220(7):e202010006.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Korobova F, Gauvin TJ, Higgs HN. A role for myosin II in mammalian mitochondrial fission. Curr Biol. 2014;24(4):409–14.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cho B, Cho HM, Jo Y, Kim HD, Song M, Moon C, et al. Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division. Nat Commun. 2017;8:15754.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chakrabarti R, Ji WK, Stan RV, de Juan SJ, Ryan TA, Higgs HN. INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. J Cell Biol. 2018;217(1):251–68.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pepe S. Mitochondrial function in ischaemia and reperfusion of the ageing heart. Clin Exp Pharmacol Physiol. 2000;27(9):745–50.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bhosale G, Sharpe JA, Koh A, Kouli A, Szabadkai G, Duchen MR. Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics. Biochim Biophys Acta Mol Cell Res. 2017;1864(6):1009–17.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nagashima S, Tábara LC, Tilokani L, Paupe V, Anand H, Pogson JH, et al. Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division. Science. 2020;367(6484):1366–71.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tábara LC, Morris JL, Prudent J. The complex dance of organelles during mitochondrial division. Trends Cell Biol. 2021;31(4):241–53.

    Article 
    PubMed 

    Google Scholar
     

  • Chen J, Chen ZJ. PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature. 2018;564(7734):71–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • de la Roche M, Hamilton C, Mortensen R, Jeyaprakash AA, Ghosh S, Anand PK. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217(10):3560–76.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ganesan V, Willis SD, Chang KT, Beluch S, Cooper KF, Strich R. Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission. Mol Biol Cell. 2019;30(3):302–11.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang T, Hou D, He J, Zeng X, Liu R, Liu L, et al. Oxidative-damaged mitochondria activate GABARAPL1-induced NLRP3 inflammasomes in an autophagic-exosome manner after acute myocardial ischemia. Oxid Med Cell Longev. 2022;2022:7958542.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ponte S, Carvalho L, Gagliardi M, Campos I, Oliveira PJ, Jacinto A. Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing. Biol Open. 2020;9(5):bio048629.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Matuz-Mares D, González-Andrade M, Araiza-Villanueva MG, Vilchis-Landeros MM, Vázquez-Meza H. Mitochondrial calcium: effects of its imbalance in disease. Antioxidants (Basel). 2022;11(5):801.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ramachandran K, Maity S, Muthukumar AR, Kandala S, Tomar D, Abd El-Aziz TM, et al. SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics. iScience. 2022;25(1):103722.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang P, Fernandez-Sanz C, Wang W, Sheu SS. Why don’t mice lacking the mitochondrial Ca2+ uniporter experience an energy crisis? J Physiol. 2020;598(7):1307–26.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Eckel-Mahan KL, Patel VR, Mohney RP, Vignola KS, Baldi P, Sassone-Corsi P. Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci USA. 2012;109(14):5541–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P. Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science. 2009;324(5927):654–7.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cela O, Scrima R, Pazienza V, Merla G, Benegiamo G, Augello B, et al. Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos. Biochim Biophys Acta. 2016;1863(4):596–606.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Anding AL, Baehrecke EH. Cleaning house: selective autophagy of organelles. Dev Cell. 2017;41(1):10–22.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jin M, Liu X, Klionsky DJ. SnapShot: selective autophagy. Cell. 2013;152(1–2):368.e2.


    Google Scholar
     

  • Wu W, Li W, Chen H, Jiang L, Zhu R, Feng D. FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy. Autophagy. 2016;12(9):1675–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, et al. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 2016;35(13):1368–84.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen SD, Lin TK, Yang DI, Lee SY, Shaw FZ, Liou CW, et al. Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury. Biochem Biophys Res Commun. 2015;460(2):397–403.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Han H, Tan J, Wang R, Wan H, He Y, Yan X, et al. PINK1 phosphorylates Drp 1(S616) to regulate mitophagy-independent mitochondrial dynamics. EMBO Rep. 2020;21(8):e48686.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Buhlman L, Damiano M, Bertolin G, Ferrando-Miguel R, Lombès A, Brice A, et al. Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance. Biochim Biophys Acta. 2014;1843(9):2012–26.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Saito T, Nah J, Oka SI, Mukai R, Monden Y, Maejima Y, et al. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. J Clin Invest. 2019;129(2):802–19.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Toyama EQ, Herzig S, Courchet J, Lewis TL Jr, Losón OC, Hellberg K, et al. Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science. 2016;351(6270):275–81.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang J, Zhu P, Li R, Ren J, Zhou H. Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission. Redox Biol. 2020;30:101415.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bonello F, Hassoun SM, Mouton-Liger F, Shin YS, Muscat A, Tesson C, et al. LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease. Hum Mol Genet. 2019;28(10):1645–60.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Burman JL, Pickles S, Wang C, Sekine S, Vargas JNS, Zhang Z, et al. Mitochondrial fission facilitates the selective mitophagy of protein aggregates. J Cell Biol. 2017;216(10):3231–47.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • D’Arcy MS. Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 2019;43(6):582–92.

    Article 
    PubMed 

    Google Scholar
     

  • Jenner A, Peña-Blanco A, Salvador-Gallego R, Ugarte-Uribe B, Zollo C, Ganief T, et al. DRP1 interacts directly with BAX to induce its activation and apoptosis. EMBO J. 2022;41(8):e108587.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wasiak S, Zunino R, McBride HM. Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J Cell Biol. 2007;177(3):439–50.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Solesio ME, Saez-Atienzar S, Jordán J, Galindo MF. Characterization of mitophagy in the 6-hydoxydopamine Parkinson’s disease model. Toxicol Sci. 2012;129(2):411–20.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yen JH, Huang HS, Chuang CJ, Huang ST. Activation of dynamin-related protein 1 – dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone. J Exp Clin Cancer Res. 2019;38(1):42.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis N. Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta. 2013;1833(12):3448–59.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu J, Yan W, Zhao X, Jia Q, Wang J, Zhang H, et al. Sirt3 attenuates post-infarction cardiac injury via inhibiting mitochondrial fission and normalization of AMPK-Drp1 pathways. Cell Signal. 2019;53:1–13.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tian X, Zhao Y, Yang Z, Lu Q, Zhou L, Zheng S. USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion. Cell Death Dis. 2022;13(9):823.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hou L, Zhang J, Liu Y, Fang H, Liao L, Wang Z, et al. MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2/Drp1 pathway. Free Radic Biol Med. 2021;165:219–28.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sun L, Ye H, Tian H, Xu L, Cai J, Zhang C, et al. The E3 ubiquitin ligase SYVN1 plays an antiapoptotic role in polycystic ovary syndrome by regulating mitochondrial fission. Oxid Med Cell Longev. 2022;2022:3639302.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu X, Shi F, Li Y, Yu X, Peng S, Li W, et al. Post-translational modifications as key regulators of TNF-induced necroptosis. Cell Death Dis. 2016;7(7):e2293.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dorn GW 2nd, Kitsis RN. The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. Circ Res. 2015;116(1):167–82.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R, et al. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Rep. 2013;5(4):878–85.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dong Y, Undyala VVR, Przyklenk K. Inhibition of mitochondrial fission as a molecular target for cardioprotection: critical importance of the timing of treatment. Basic Res Cardiol. 2016;111(5):59.

    Article 
    PubMed 

    Google Scholar
     

  • Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, et al. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014;15(12):1126–33.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li YE, Sowers JR, Hetz C, Ren J. Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases. Cell Death Dis. 2022;13(5):504.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang X, Li Q, He S, Bai J, Ma C, Zhang L, et al. LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation. Mol Med. 2022;28(1):126.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Miao Z, Tian W, Ye Y, Gu W, Bao Z, Xu L, et al. Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1. Cell Death Dis. 2022;13(6):548.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, et al. Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence. Sci Signal. 2018;11(556):eaat5185.

    Article 
    PubMed 

    Google Scholar
     

  • Chen YC, Cheng TH, Lin WL, Chen CL, Yang WY, Blackstone C, et al. Srv2 is a pro-fission factor that modulates yeast mitochondrial morphology and respiration by regulating actin assembly. iScience. 2019;11:305–17.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Strack S, Wilson TJ, Cribbs JT. Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules. J Cell Biol. 2013;201(7):1037–51.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Giovarelli M, Zecchini S, Martini E, Garre M, Barozzi S, Ripolone M, et al. Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle. Cell Death Differ. 2020;27(8):2383–401.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • McLelland GL, Lee SA, McBride HM, Fon EA. Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system. J Cell Biol. 2016;214(3):275–91.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Soubannier V, McLelland GL, Zunino R, Braschi E, Rippstein P, Fon EA, et al. A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr Biol. 2012;22(2):135–41.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Howard M, Erickson J, Cuba Z, Kim S, Zhou W, Gade P, et al. A secretory form of Parkin-independent mitophagy contributes to the repertoire of extracellular vesicles released into the tumour interstitial fluid in vivo. J Extracell Vesicles. 2022;11(7):e12244.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li H, Alavian KN, Lazrove E, Mehta N, Jones A, Zhang P, et al. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nat Cell Biol. 2013;15(7):773–85.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • König T, Nolte H, Aaltonen MJ, Tatsuta T, Krols M, Stroh T, et al. MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control. Nat Cell Biol. 2021;23(12):1271–86.

    Article 
    PubMed 

    Google Scholar
     

  • Lackner LL, Nunnari J. Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. Chem Biol. 2010;17(6):578–83.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Park J, Choi H, Min JS, Park SJ, Kim JH, Park HJ, et al. Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells. J Neurochem. 2013;127(2):221–32.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li Y, Wang P, Wei J, Fan R, Zuo Y, Shi M, et al. Inhibition of Drp1 by Mdivi-1 attenuates cerebral ischemic injury via inhibition of the mitochondria-dependent apoptotic pathway after cardiac arrest. Neuroscience. 2015;311:67–74.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sharp WW, Beiser DG, Fang YH, Han M, Piao L, Varughese J, et al. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015;43(2):e38–47.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Deng Y, Li S, Chen Z, Wang W, Geng B, Cai J. Mdivi-1, a mitochondrial fission inhibitor, reduces angiotensin-II- induced hypertension by mediating VSMC phenotypic switch. Biomed Pharmacother. 2021;140:111689.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jia Q, Li L, Wang X, Wang Y, Jiang K, Yang K, et al. Hesperidin promotes gastric motility in rats with functional dyspepsia by regulating Drp1-mediated ICC mitophagy. Front Pharmacol. 2022;13:945624.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Maneechote C, Palee S, Kerdphoo S, Jaiwongkam T, Chattipakorn SC, Chattipakorn N. Modulating mitochondrial dynamics attenuates cardiac ischemia-reperfusion injury in prediabetic rats. Acta Pharmacol Sin. 2022;43(1):26–38.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ong SB, Kwek XY, Katwadi K, Hernandez-Resendiz S, Crespo-Avilan GE, Ismail NI, et al. Targeting mitochondrial fission using Mdivi-1 in a clinically relevant large animal model of acute myocardial infarction: a pilot study. Int J Mol Sci. 2019;20(16):3972.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, et al. The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species. Dev Cell. 2017;40(6):583-94.e6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ding J, Zhang Z, Li S, Wang W, Du T, Fang Q, et al. Mdivi-1 alleviates cardiac fibrosis post myocardial infarction at infarcted border zone, possibly via inhibition of Drp1-Activated mitochondrial fission and oxidative stress. Arch Biochem Biophys. 2022;718:109147.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ruiz A, Quintela-López T, Sánchez-Gómez MV, Gaminde-Blasco A, Alberdi E, Matute C. Mitochondrial division inhibitor 1 disrupts oligodendrocyte Ca2+ homeostasis and mitochondrial function. Glia. 2020;68(9):1743–56.

    Article 
    PubMed 

    Google Scholar
     

  • Li Y, Mei NH, Cheng GP, Yang J, Zhou LQ. Inhibition of DRP1 impedes zygotic genome activation and preimplantation development in mice. Front Cell Dev Biol. 2021;9:788512.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Qi X, Qvit N, Su YC, Mochly-Rosen D. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci. 2013;126(Pt 3):789–802.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Filichia E, Hoffer B, Qi X, Luo Y. Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP. Sci Rep. 2016;6:32656.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Haileselassie B, Mukherjee R, Joshi AU, Napier BA, Massis LM, Ostberg NP, et al. Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy. J Mol Cell Cardiol. 2019;130:160–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu W, Su C, Qi Y, Liang J, Zhao L, Shi Y. Brain-targeted heptapeptide-loaded exosomes attenuated ischemia-reperfusion injury by promoting the transfer of healthy mitochondria from astrocytes to neurons. J Nanobiotechnology. 2022;20(1):242.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mancini NL, Goudie L, Xu W, Sabouny R, Rajeev S, Wang A, et al. Perturbed mitochondrial dynamics is a novel feature of colitis that can be targeted to lessen disease. Cell Mol Gastroenterol Hepatol. 2020;10(2):287–307.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Solesio ME, Prime TA, Logan A, Murphy MP, Del Mar A-J, Jordán J, et al. The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson’s disease. Biochim Biophys Acta. 2013;1832(1):174–82.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xi Y, Feng D, Tao K, Wang R, Shi Y, Qin H, et al. MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α. Biochim Biophys Acta Mol Basis Dis. 2018;1864(9 Pt B):2859–70.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sun C, Liu X, Di C, Wang Z, Mi X, Liu Y, et al. MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential. Autophagy. 2017;13(4):730–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A, et al. Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension. Eur Respir J. 2018;51(3):1701024.

    Article 

    Google Scholar
     

  • Botting KJ, Skeffington KL, Niu Y, Allison BJ, Brain KL, Itani N, et al. Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction. Sci Adv. 2020;6(34):eabb1929.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dhapola R, Sarma P, Medhi B, Prakash A, Reddy DH. Recent advances in molecular pathways and therapeutic implications targeting mitochondrial dysfunction for Alzheimer’s disease. Mol Neurobiol. 2022;59(1):535–55.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen W, Guo C, Huang S, Jia Z, Wang J, Zhong J, et al. MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH. Pharmacol Res. 2020;161:105122.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hamed M, Logan A, Gruszczyk AV, Beach TE, James AM, Dare AJ, et al. Mitochondria-targeted antioxidant MitoQ ameliorates ischaemia-reperfusion injury in kidney transplantation models. Br J Surg. 2021;108(9):1072–81.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006;10(6):839–50.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Martinez-Carrasco R, Argüeso P, Fini ME. Dynasore protects ocular surface mucosal epithelia subjected to oxidative stress by maintaining UPR and calcium homeostasis. Free Radic Biol Med. 2020;160:57–66.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Clemente LP, Rabenau M, Tang S, Stanka J, Cors E, Stroh J, et al. Dynasore blocks ferroptosis through combined modulation of iron uptake and inhibition of mitochondrial respiration. Cells. 2020;9(10):2259.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ailenberg M, Di Ciano-Oliveira C, Szaszi K, Dan Q, Rozycki M, Kapus A, et al. Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis-independent NF-κB activation. Br J Pharmacol. 2015;172(15):3748–63.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu D, Dasgupta A, Chen KH, Neuber-Hess M, Patel J, Hurst TE, et al. Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury. FASEB J. 2020;34(1):1447–64.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang J, Chen P, Cao Y, Liu S, Wang W, Li L, et al. Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction. Cell Chem Biol. 2023;30(3):278-94.e11.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rosdah AA, Abbott BM, Langendorf CG, Deng Y, Truong JQ, Waddell HMM, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022;12(1):21531.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kwong JQ, Lu X, Correll RN, Schwanekamp JA, Vagnozzi RJ, Sargent MA, et al. The mitochondrial calcium uniporter selectively matches metabolic output to acute contractile stress in the heart. Cell Rep. 2015;12(1):15–22.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, et al. The mitochondrial calcium uniporter matches energetic supply with cardiac workload during stress and modulates permeability transition. Cell Rep. 2015;12(1):23–34.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bovo E, Lipsius SL, Zima AV. Reactive oxygen species contribute to the development of arrhythmogenic Ca2+ waves during β-adrenergic receptor stimulation in rabbit cardiomyocytes. J Physiol. 2012;590(14):3291–304.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, et al. Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid Redox Signal. 2014;21(6):863–79.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • van der Ende M, Grefte S, Plas R, Meijerink J, Witkamp RF, Keijer J, et al. Mitochondrial dynamics in cancer-induced cachexia. Biochim Biophys Acta Rev Cancer. 2018;1870(2):137–50.

    Article 
    PubMed 

    Google Scholar
     



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