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Some Molecular Characterization of βeta-Thalassemia Major In Koya City

2018 International Conference on Pure and Applied Science

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Title Some Molecular Characterization of βeta-Thalassemia Major In Koya City
Creator Kochar Kh. Saleh; Department of Community Health, Koya Technical Institute, Erbil Polytechnic University, Kurdistan Region
Esmail S. Kakey; Department of Biology, Faculty of Science and Health, Koya University, Kurdistan Region
Subject Biology
βeta-Thalassemia; Molecular Characterization; Mutations.
Description βeta-thalassemia is an important health problem in Kurdistan region and clinical characterization of βeta-thalassemia problems revealed in Koya City, its require more investigation and screening of βeta-thalassemia patients and proper control programs, about 90 children suffering by different types of thalassemia in Koya City. The present study aims to investigate some molecular characterization and most common mutations that affect βeta-thalassemia patients. About 10 milliliters of venous blood sample was taken from 43 βeta-thalassemia patients prior to the scheduled blood transfusion by using a disposable syringe used for DNA extraction, then molecular studies by using a polymerase chain reaction-amplification refractory mutation system (ARMS-PCR) technique. Four common mutations in the βeta-thalassemia patients, which were (IVSII-1, codon 8/9, cd 44 and IVS1-5), and these four mutations are detected in 36 among 43 patients, representing 83.7% βeta-thalassemia patients. The most common mutation identified was (IVSII-1). Published 01 August 2018DOI: 10.14500/icpas2018.bph25
Publisher Pure and Applied Science
Contributor Koya University
Date 2018-03-27 16:07:01
Type Peer-reviewed Paper
Format application/pdf
Source Pure and Applied Science; 2018 International Conference on Pure and Applied Science
Language en
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