Record Details

Synthesis of a model trehalose ester (cord factor), and study its antigenic properties

2018 International Conference on Pure and Applied Science

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Field Value
 
Title Synthesis of a model trehalose ester (cord factor), and study its antigenic properties
 
Creator Salam G. Taher; Department of Chemistry, Faculty of Science and Health, Koya University, Kurdistan Region
 
Subject Applied Chemistry
Biological activities of mycolic acids; Mycolic acids; Mycolic acids (cord factors)
 
Description The work involves the synthesis of a novel model cord factor of β-hydroxy carboxylic acid esterified with trehalose sugar using standard methods. The synthesized compounds are similar and simpler than those of mycoloic acids found in the cell wall of many mycobacterial species. These compounds will be tested for their antigenic ability to bind to antibody of infected serums samples obtained from infected patients with mycobactrim species. This is to compare the biological activities of those model cord factors of β-hydroxy carboxylic acids with the natural cord factors of complete α-alkylated mycolic acids found in mycobacterial cell wall. ELISA assays will be carried out using the products as antigens to detect antibodies in serum of patients diagnosed with active mycobacterium tuberculosis. Published 01 August 2018DOI: 10.14500/icpas2018.ach70http://dx.doi.org/10.14500/icpas2018.ach70
 
Publisher Pure and Applied Science
 
Contributor Koya University
 
Date 2018-03-15 06:02:27
 
Type Peer-reviewed Paper
 
Format application/pdf
 
Identifier http://conferences.koyauniversity.org/index.php/pas/2018/paper/view/70
 
Source Pure and Applied Science; 2018 International Conference on Pure and Applied Science
 
Language en
 
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