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The Methylation Analysis of Mir-210 in NSCLC Patients

International Journal of progressive Sciences and Technologies

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Title The Methylation Analysis of Mir-210 in NSCLC Patients
Creator Masrouri, Masoumeh
Nooshin, Sajad
Matin Ahmadi, Arash
Zare zadeh, Roya
Mohammadnejad pahmadani, Mojtaba
Karimipoor, Morteza
Lung Cancer; Non-Small Cell Lung Cancer (NSCLC); Mir-210; MS-PCR Method.

Description Background: Because of the importance of lung cancer worldwide, as well as the deaths from it. So far, various studies have been conducted on this cancer. Epigenetic changes are one of the factors contributing to lung cancer that the most important of these changes are DNA methylation. Various biomarkers such as microRNAs can be used to detect cancer. In addition, many studies have been performed on the relationship between cancer and microRNAs. In this study, the methylation status of mir-210 was investigated in NSCLC tissues.Method: The methylation status of mir-210 was checked in 30 patients with NSCLC and 30 adjacent normal tissues using the MS-PCR method.Results: This paper reported that there was no significant difference between methylation level of tumor samples and adjacent normal samples. so that all of the normal samples were in methylated state and only 4 (13.33%) cases of tumor samples were in a unmethylated state (P>0.05). The results obtained from our study confirmed that hypomethylation and therefore overexpression of mir-210 didn’t occur in early stages of non-small cell lung cancer.
Publisher International Journals of Sciences and High Technologies
Date 2018-03-03
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Source International Journal of Progressive Sciences and Technologies; Vol 7, No 1 (2018); 76-80
Language eng
Rights Copyright (c) 2018 Masoumeh Masrouri